Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Roland Stein"'
Autor:
Jeeyeon Cha, Xin Tong, Emily M. Walker, Tehila Dahan, Veronica A. Cochrane, Sudipta Ashe, Ronan Russell, Anna B. Osipovich, Alex M. Mawla, Min Guo, Jin-hua Liu, Zachary A. Loyd, Mark O. Huising, Mark A. Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Type 2 diabetes (T2D) is associated with compromised identity of insulin-producing pancreatic islet β cells, characterized by inappropriate production of other islet cell–enriched hormones. Here, we examined how hormone misexpression was influence
Externí odkaz:
https://doaj.org/article/d8557c8689a94c42a21473f2861b2627
Autor:
Ronan Russell, Phichitpol P. Carnese, Thomas G. Hennings, Emily M. Walker, Holger A. Russ, Jennifer S. Liu, Simone Giacometti, Roland Stein, Matthias Hebrok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The MAF bZIP transcription factor B (MAFB) is present in postnatal human beta cells but its role is unclear. Here, the authors show that MAFB regulates endocrine pancreatic cell fate specification.
Externí odkaz:
https://doaj.org/article/e0d2c3d6cf86401bb280695fe609017c
Autor:
Shristi Shrestha, Diane C. Saunders, John T. Walker, Joan Camunas-Soler, Xiao-Qing Dai, Rachana Haliyur, Radhika Aramandla, Greg Poffenberger, Nripesh Prasad, Rita Bottino, Roland Stein, Jean-Philippe Cartailler, Stephen C.J. Parker, Patrick E. MacDonald, Shawn E. Levy, Alvin C. Powers, Marcela Brissova
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Islet-enriched transcription factors (TFs) exert broad control over cellular processes in pancreatic α and β cells, and changes in their expression are associated with developmental state and diabetes. However, the implications of heterogeneity in
Externí odkaz:
https://doaj.org/article/a176612b370447eeb2aad97352fda235
Autor:
Marcela Brissova, Rachana Haliyur, Diane Saunders, Shristi Shrestha, Chunhua Dai, David M. Blodgett, Rita Bottino, Martha Campbell-Thompson, Radhika Aramandla, Gregory Poffenberger, Jill Lindner, Fong Cheng Pan, Matthias G. von Herrath, Dale L. Greiner, Leonard D. Shultz, May Sanyoura, Louis H. Philipson, Mark Atkinson, David M. Harlan, Shawn E. Levy, Nripesh Prasad, Roland Stein, Alvin C. Powers
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2667-2676 (2018)
Summary: Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual
Externí odkaz:
https://doaj.org/article/179fb49bdb1e47cd9d5843dc1eb65012
Autor:
Elvira Ganic, Tania Singh, Cheng Luan, João Fadista, Jenny K. Johansson, Holly Ann Cyphert, Hedvig Bennet, Petter Storm, Gaëlle Prost, Henrik Ahlenius, Erik Renström, Roland Stein, Leif Groop, Malin Fex, Isabella Artner
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1991-2002 (2016)
Monoamine and acetylcholine neurotransmitters from the autonomic nervous system (ANS) regulate insulin secretion in pancreatic islets. The molecular mechanisms controlling neurotransmitter signaling in islet β cells and their impact on diabetes deve
Externí odkaz:
https://doaj.org/article/acc04e86c0344999b8bf65613bd9605f
Publikováno v:
Cell Reports, Vol 10, Iss 12, Pp 2032-2042 (2015)
Pdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet β cell function. However, little is known about the positive- and negative-acting coregulators recruited to mediate transcriptional control. Here, we isol
Externí odkaz:
https://doaj.org/article/d73ab065de174678b8b08d5f07816696
Autor:
Joachim Diessner, Manfred Wischnewsky, Maria Blettner, Sebastian Häusler, Wolfgang Janni, Rolf Kreienberg, Roland Stein, Tanja Stüber, Lukas Schwentner, Catharina Bartmann, Achim Wöckel
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168730 (2016)
Luminal A breast cancers respond well to anti-hormonal therapy (HT), are associated with a generally favorable prognosis and constitute the majority of breast cancer subtypes. HT is the mainstay of treatment of these patients, accompanied by an accep
Externí odkaz:
https://doaj.org/article/f61a078cfbcf4f5b91db9d88b0e78084
Publikováno v:
Educational Psychology Review. 35
Research suggests that children suffering from different types of disorders (learning disorders, behavioral disorders, or intellectual disabilities) are sometimes evaluated differently simply due to the presence of a diagnostic label. We conducted a
Publikováno v:
Vierteljahresschrift für Heilpädagogik und ihre Nachbargebiete.
Publikováno v:
Vierteljahresschrift für Heilpädagogik und ihre Nachbargebiete. 90:268-282
Der vorliegende, interdisziplinare Beitrag fokussiert im Kontext einer ethischen Auseinandersetzung aus philosophischer sowie sonderpadagogischer Perspektive in ihrer Interaktion eine begriffliche Analyse sowie eine Verortung von Inklusion als normat