Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Roland Schule"'
Autor:
Hannah Maria Baumert, Eric Metzger, Matthias Fahrner, Julie George, Roman K. Thomas, Oliver Schilling, Roland Schüle
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Lung cancer is the leading cause of cancer related death worldwide. Over the past 15 years no major improvement of survival rates could be accomplished. The recently discovered histone methyltransferase KMT9 that acts as epigeneti
Externí odkaz:
https://doaj.org/article/18690fb746304b5f9a4a208fa7e2a7dc
Publikováno v:
Mountain Research and Development, Vol 38, Iss 2, Pp 114-124 (2018)
Mount Kenya serves as a natural water tower in the savanna-dominated Upper Ewaso Ng'iro River Basin in the Kenyan highlands. Major water users in the upper reaches of the river include medium- and large-scale commercial horticulture farms that produc
Externí odkaz:
https://doaj.org/article/5080f416a5e64b529bf073129aa03f97
Autor:
Isabella Scionti, Shinichiro Hayashi, Sandrine Mouradian, Emmanuelle Girard, Joana Esteves de Lima, Véronique Morel, Thomas Simonet, Maud Wurmser, Pascal Maire, Katia Ancelin, Eric Metzger, Roland Schüle, Evelyne Goillot, Frederic Relaix, Laurent Schaeffer
Publikováno v:
Cell Reports, Vol 18, Iss 8, Pp 1996-2006 (2017)
MyoD is a master regulator of myogenesis. Chromatin modifications required to trigger MyoD expression are still poorly described. Here, we demonstrate that the histone demethylase LSD1/KDM1a is recruited on the MyoD core enhancer upon muscle differen
Externí odkaz:
https://doaj.org/article/df842c1b9ad94a8c89dc918ed4dc92ec
Autor:
Delphine Duteil, Milica Tosic, Franziska Lausecker, Hatice Z. Nenseth, Judith M. Müller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, Jens C. Brüning, Vyacheslav Zagoriy, Michael Meret, Jörn Dengjel, Toufike Kanouni, Roland Schüle
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1008-1021 (2016)
Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-sel
Externí odkaz:
https://doaj.org/article/15acdfef4129450fb67865a1bd83d169
Autor:
Martin Hügle, Xavier Lucas, Gerhard Weitzel, Dmytro Ostrovskyi, Bernhard Breit, Stefan Gerhardt, Karin Schmidtkunz, Manfred Jung, Roland Schüle, Oliver Einsle, Stefan Günther, Daniel Wohlwend
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 1370-1374 (2016)
This article presents detailed purification procedures for the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B. In addition we provide crystallization protocols for apo BRD4(1) and BRD4(1) in complex with numerous inhibitors. The protocols describ
Externí odkaz:
https://doaj.org/article/6301727c76704813bd8737a83f4fc8fd
Autor:
Changmeng Cai, Housheng Hansen He, Shuai Gao, Sen Chen, Ziyang Yu, Yanfei Gao, Shaoyong Chen, Mei Wei Chen, Jesse Zhang, Musaddeque Ahmed, Yang Wang, Eric Metzger, Roland Schüle, X. Shirley Liu, Myles Brown, Steven P. Balk
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1618-1627 (2014)
Summary: Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear. We show that LSD1, in
Externí odkaz:
https://doaj.org/article/f867846ff1bd4450a1dac4a6e61a8c5c
Autor:
Theresa Pohlkamp, Laura Steller, Petra May, Thomas Günther, Roland Schüle, Michael Frotscher, Joachim Herz, Hans H Bock
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100384 (2014)
We created an Nse-CreERT2 mouse line expressing the tamoxifen-inducible CreERT2 recombinase under the control of the neuron-specific enolase (Nse) promoter. By using Cre reporter lines we could show that this Nse-CreERT2 line has recombination activi
Externí odkaz:
https://doaj.org/article/4179a8b5d7c24d8984ef671d6db78fbe
Autor:
Julia Brun, François-Xavier Dieudonné, Caroline Marty, Judith Müller, Roland Schüle, Ana Patiño-García, Fernando Lecanda, Olivia Fromigué, Pierre J Marie
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55034 (2013)
BACKGROUND: The molecular mechanisms that are involved in the growth and invasiveness of osteosarcoma, an aggressive and invasive primary bone tumor, are not fully understood. The transcriptional co-factor FHL2 (four and a half LIM domains protein 2)
Externí odkaz:
https://doaj.org/article/01e9bf69aa094f2f95ed1a6d665f74ad
Autor:
Jens Köhler, German Erlenkamp, Adrien Eberlin, Tobias Rumpf, Inna Slynko, Eric Metzger, Roland Schüle, Wolfgang Sippl, Manfred Jung
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34973 (2012)
BACKGROUND: Epigenetics is defined as heritable changes in gene expression that are not based on changes in the DNA sequence. Posttranslational modification of histone proteins is a major mechanism of epigenetic regulation. The kinase PRK1 (protein k
Externí odkaz:
https://doaj.org/article/aa12995d6bce4f1ca43c8fdd7b449c43
Autor:
Cristina Lopez, Nikolai Schleussner, Stephan H. Bernhart, Kortine Kleinheinz, Stephanie Sungalee, Henrike L. Sczakiel, Helene Kretzmer, Umut H. Toprak, Selina Glaser, Rabea Wagener, Ole Ammerpohl, Susanne Bens, Maciej Giefing, Juan C. Gonzalez Sanchez, Gordana Apic, Daniel Hubschmann, Martin Janz, Markus Kreuz, Anja Mottok, Judith M. Muller, Julian Seufert, Steve Hoffmann, Jan O. Korbel, Robert B. Russell, Roland Schule, Lorenz Trumper, Wolfram Klapper, Bernhard Radlwimmer, Peter Lichter, Ralf Kuppers, Matthias Schlesner, Stephan Mathas, Reiner Siebert
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Histone methylation-modifiers, such as EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated who
Externí odkaz:
https://doaj.org/article/3d3b5d4cbb534e4eb3816d334f4e9a3c