Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Roland Schönherr"'
Autor:
Philipp Rühl, Anagha G. Nair, Namrata Gawande, Sassrika N. C. W. Dehiwalage, Lukas Münster, Roland Schönherr, Stefan H. Heinemann
Publikováno v:
Advanced Science, Vol 11, Iss 20, Pp n/a-n/a (2024)
Abstract Most animal cell types are classified as non‐excitable because they do not generate action potentials observed in excitable cells, such as neurons and muscle cells. Thus, resolving voltage signals in non‐excitable cells demands sensors w
Externí odkaz:
https://doaj.org/article/855ab7dcc8a641398d50a0adff01d055
Autor:
Nirakar Sahoo, Kefan Yang, Ina Coburger, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has b
Externí odkaz:
https://doaj.org/article/845788ec9f91486e9f2c2f0cbd2a94fb
Autor:
Philipp Rühl, Johanna M. Langner, Jasmin Reidel, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Rühl et al. report the generation of ratiometric genetically encoded voltage indicators (GEVIs) and establish that they can be used in high-throughput automated imaging to measure compound membrane potential (Vm) in mammalian cells. This method is i
Externí odkaz:
https://doaj.org/article/d8fdccc7299e4650ba56c7bdfa3b227d
Autor:
Sandra-Annika Quast, Anja Berger, Nicole Buttstädt, Kristin Friebel, Roland Schönherr, Jürgen Eberle
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39290 (2012)
The death ligand TRAIL represents a promising therapeutic strategy for metastatic melanoma, however prevalent and inducible resistance limit its applicability. A new approach is presented here for sensitization to TRAIL. It is based on inhibition of
Externí odkaz:
https://doaj.org/article/9ab970dbc41a41949cac9cedc83c7d87
Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated Na+ channels
Autor:
Guido Gessner, Mahdi Jamili, Pascal Tomczyk, Dirk Menche, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann
Publikováno v:
Biol Chem
Heme (Fe2+-protoporphyrin IX) is a well-known protein prosthetic group; however, heme and hemin (Fe3+-protoporphyrin IX) are also increasingly viewed as signaling molecules. Among the signaling targets are numerous ion channels, with intracellular-fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c391a6302b5f4e5efb086368d7728023
https://doi.org/10.1515/hsz-2022-0194
https://doi.org/10.1515/hsz-2022-0194
Publikováno v:
Free radical biologymedicine. 192
Selenomethionine (SeMet) randomly replaces methionine (Met) in protein translation. Because of strongly differing redox properties of SeMet and Met, SeMet mis-incorporation may have detrimental effects on protein function, possibly compromising the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abce9d502716483bbf28ffbfb8d2351e
https://pubmed.ncbi.nlm.nih.gov/36152916
https://pubmed.ncbi.nlm.nih.gov/36152916
Autor:
Alisa Bernert, Sandip M. Swain, Eric Wiesel, Nirakar Sahoo, Kefan Yang, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann, Ina Coburger
Publikováno v:
Pflugers Archiv
N-type inactivation of voltage-gated K+ channels is conferred by the N-terminal “ball” domains of select pore-forming α subunits or of auxiliary β subunits, and influences electrical cellular excitability. Here, we show that hemin impairs inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3395e2b94f3cf590a86e6fb3bd6dfa8
http://europepmc.org/articles/PMC7239824
http://europepmc.org/articles/PMC7239824
Autor:
Nikita Kuldyushev, Roland Schönherr, Ina Coburger, Marwa Ahmed, Rama A. Hussein, Eric Wiesel, Amod Godbole, Thorsten Pfirrmann, Toshinori Hoshi, Stefan H. Heinemann
Publikováno v:
Talanta
Methionine oxidation is a reversible post-translational protein modification, affecting protein function, and implicated in aging and degenerative diseases. The detection of accumulating methionine oxidation in living cells or organisms, however, has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013a167a47b46b0d38e6c1c7f4b2ff1b
https://pubmed.ncbi.nlm.nih.gov/35276500
https://pubmed.ncbi.nlm.nih.gov/35276500
Publikováno v:
Reviews of physiology, biochemistry and pharmacology. 181
Recent research has revealed that ion channels and transporters can be important players in tumor development, progression, and therapy resistance in melanoma. For example, members of the ABC family were shown to support cancer stemness-like features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fd39a378fcae27775c64181a897e26a
https://pubmed.ncbi.nlm.nih.gov/32737752
https://pubmed.ncbi.nlm.nih.gov/32737752
Publikováno v:
Reviews of Physiology, Biochemistry and Pharmacology ISBN: 9783030909192
Recent research has revealed that ion channels and transporters can be important players in tumor development, progression, and therapy resistance in melanoma. For example, members of the ABC family were shown to support cancer stemness-like features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1b700cf80bd0db59e80e7bef6626cc7
https://doi.org/10.1007/112_2020_17
https://doi.org/10.1007/112_2020_17
