Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Roland S G, Jones"'
Autor:
Anderson Brito da Silva, Jane Pennifold, Ben Henley, Koustav Chatterjee, David Bateman, Roger W. Whittaker, Abhijit Joshi, Hrishikesh Kumar, Claire Nicholson, Mark R. Baker, Stuart D. Greenhill, Richard Walsh, Stefano Seri, Roland S. G. Jones, Gavin L. Woodhall, Mark O. Cunningham
Publikováno v:
Epilepsia Open, Vol 7, Iss 3, Pp 488-495 (2022)
Abstract Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresis
Externí odkaz:
https://doaj.org/article/4f75c11420504a2b92f84ffdac58cc0c
Autor:
Tamara Modebadze, Nicola H Morgan, Isabelle A A Pérès, Rebecca D Hadid, Naoki Amada, Charlotte Hill, Claire Williams, Ian M Stanford, Christopher M Morris, Roland S G Jones, Benjamin J Whalley, Gavin L Woodhall
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147265 (2016)
Animal models of acquired epilepsies aim to provide researchers with tools for use in understanding the processes underlying the acquisition, development and establishment of the disorder. Typically, following a systemic or local insult, vulnerable b
Externí odkaz:
https://doaj.org/article/62dc5808fa0e481ea7127988e2c6b16c
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133548 (2015)
Partial agonists at the NMDA receptor co-agonist binding site may have potential therapeutic efficacy in a number of cognitive and neurological conditions. The entorhinal cortex is a key brain area in spatial memory and cognitive processing. At synap
Externí odkaz:
https://doaj.org/article/e69d8cfa4bb54859b29a317d762b109c
Publikováno v:
Neural Plasticity, Vol 2008 (2008)
Externí odkaz:
https://doaj.org/article/8422a9a5221b466685167958ba4f584b
Publikováno v:
Neural Plasticity, Vol 2008 (2008)
We have previously shown that spontaneous release of glutamate in the entorhinal cortex (EC) is tonically facilitated via activation of presynaptic NMDA receptors (NMDAr) containing the NR2B subunit. Here we show that the same receptors mediate short
Externí odkaz:
https://doaj.org/article/0518d181107f4ebba2d23a6597ca7588
Autor:
Emma J, Prokic, Cathryn, Weston, Naoki, Yamawaki, Stephen D, Hall, Roland S G, Jones, Ian M, Stanford, Graham, Ladds, Gavin L, Woodhall
Publikováno v:
Neuropharmacology. 95
Tonic conductance mediated by extrasynaptic GABAA receptors has been implicated in the modulation of network oscillatory activity. Using an in vitro brain slice to produce oscillatory activity and a kinetic model of GABAA receptor dynamics, we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c76cbb426ec9ee044650ff4f0b495f5f
https://pubmed.ncbi.nlm.nih.gov/25797493
https://pubmed.ncbi.nlm.nih.gov/25797493
Publikováno v:
The Journal of physiology. 586(20)
NMDA receptors (NMDAr) are known to undergo recycling and lateral diffusion in postsynaptic spines and dendrites. However, NMDAr are also present as autoreceptors on glutamate terminals, where they act to facilitate glutamate release, but it is not k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::249008a72bcde51c45eb7204f76425d5
https://pubmed.ncbi.nlm.nih.gov/18854432
https://pubmed.ncbi.nlm.nih.gov/18854432
Autor:
Roland S G, Jones, Gavin L, Woodhall
Publikováno v:
The Journal of physiology. 562(Pt 1)
The entorhinal cortex (EC) is a key brain area controlling both hippocampal input and output via neurones in layer II and layer V, respectively. It is also a pivotal area in the generation and propagation of epilepsies involving the temporal lobe. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f30cd3d0a0e16f0ccd5777570d4f1a8
https://pubmed.ncbi.nlm.nih.gov/15498804
https://pubmed.ncbi.nlm.nih.gov/15498804
Publikováno v:
The European journal of neuroscience. 16(10)
Using whole-cell patch-clamp recordings of spontaneous synaptic activity, we have previously shown that activation of neurokinin-1 (NK1) but not NK3 receptors leads to increased GABA release onto principal cells in the rat entorhinal cortex. In the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3dfdd434555c8fb1877cb7d93f1d74c9
https://pubmed.ncbi.nlm.nih.gov/12453053
https://pubmed.ncbi.nlm.nih.gov/12453053
Autor:
Roland S. G. Jones
Publikováno v:
Journal of neuroscience research. 6(1)
Extracellular recording and iontophoresis techniques were used to study the interactions of the trace amine, p-tyramine (p-TA) with putative neurotransmitters on single neurones in the cerebral cortex and caudate nucleus of the rat. p-TA, when applie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a50dbc350325bcef623fe4ad9b4150d
https://pubmed.ncbi.nlm.nih.gov/7218373
https://pubmed.ncbi.nlm.nih.gov/7218373