Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Roland Preece"'
Autor:
Christos Georgiadis, Lauren Nickolay, Farhatullah Syed, Hong Zhan, Soragia Athina Gkazi, Annie Etuk, Ulrike Abramowski-Mock, Roland Preece, Piotr Cuber, Stuart Adams, Giorgio Ottaviano, Waseem Qasim
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Umbilical cord blood (UCB) T cells exhibit distinct naive ontogenetic profiles and may be an attractive source of starting cells for the production of chimeric antigen receptor (CAR) T cells. Pre-selection of UCB-T cells on the basis of CD62L express
Externí odkaz:
https://doaj.org/article/cdb82ae8baf04b8389ea2a1288375c7b
Autor:
Roland Preece, Andrea Pavesi, Soragia Athina Gkazi, Kerstin A. Stegmann, Christos Georgiadis, Zhi Ming Tan, Jia Ying Joey Aw, Mala K. Maini, Antonio Bertoletti, Waseem Qasim
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 149-161 (2020)
Emerging base editing technology exploits CRISPR RNA-guided DNA modification effects for highly specific C > T conversion, which has been used to efficiently disrupt gene expression. These tools can enhance synthetic T cell immunity by restricting sp
Externí odkaz:
https://doaj.org/article/00ec11294bb54f618d18c76675005e30
Autor:
Giorgio, Ottaviano, Christos, Georgiadis, Soragia Athina, Gkazi, Farhatullah, Syed, Hong, Zhan, Annie, Etuk, Roland, Preece, Jan, Chu, Agnieszka, Kubat, Stuart, Adams, Paul, Veys, Ajay, Vora, Kanchan, Rao, Waseem, Qasim, Daesik, Kim
Publikováno v:
Science translational medicine. 14(668)
Genome editing of allogeneic T cells can provide “off-the-shelf” alternatives to autologous chimeric antigen receptor (CAR) T cell therapies. Disruption of T cell receptor α chain (TRAC) to prevent graft-versus-host disease (GVHD) and removal of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5809002722a12c073d450d9e359bc78d
https://pubmed.ncbi.nlm.nih.gov/36288281
https://pubmed.ncbi.nlm.nih.gov/36288281
Autor:
Antonio Bertoletti, Kerstin A. Stegmann, Soragia Athina Gkazi, Andrea Pavesi, Jia Ying Joey Aw, Zhi Ming Tan, Waseem Qasim, Mala K. Maini, Christos Georgiadis, Roland Preece
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 149-161 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Emerging base editing technology exploits CRISPR RNA-guided DNA modification effects for highly specific C > T conversion, which has been used to efficiently disrupt gene expression. These tools can enhance synthetic T cell immunity by restricting sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3992bcb314b53e93f2d695a96f721d6f
http://www.sciencedirect.com/science/article/pii/S232905012030187X
http://www.sciencedirect.com/science/article/pii/S232905012030187X
Autor:
Robert Chiesa, Christos Georgiadis, Giorgio Ottaviano, Farhatullah Syed, Toni Braybrook, Annie Etuk, Hong Zhan, Soragia Athina Gkazi, Roland Preece, Stuart Adams, Rebecca Thomas, Arnold Awuah, Kimberly Gilmour, Lana Mhaldien, Jan Chu, Danielle Pinner, Agnieszka Kubat, Paul Veys, Kanchan Rao, Giovanna Lucchini, David O'Connor, Ajay Vora, Waseem Qasim
Publikováno v:
Blood. 140:4579-4580
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::330ad368a0453530ea8092ed4d016896
https://doi.org/10.1182/blood-2022-169114
https://doi.org/10.1182/blood-2022-169114
Autor:
Aniekan Etuk, Christos Georgiadis, Waseem Qasim, Soragia Athina Gkazi, Roland Preece, Abraham Christi
Publikováno v:
Gene Therapy. 27:451-458
RNA polymerase III (Pol III) promoters express short non-coding RNAs and have been adopted for expression of microRNA, interference RNA, and CRISPR single guide RNA (sgRNA). Vectors incorporating H1 and U6 Pol III promoters are being applied for ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e463b1c0b65d3b5f3b49cca378882ff3
https://doi.org/10.1038/s41434-020-0142-z
https://doi.org/10.1038/s41434-020-0142-z
Autor:
Waseem Qasim, Abraham Christi, Aniekan Etuk, Roland Preece, Soragia Athina Gkazi, Christos Georgiadis, Jane Rasaiyaah
Publikováno v:
Leukemia
Targeting T cell malignancies using chimeric antigen receptor (CAR) T cells is hindered by ‘T v T’ fratricide against shared antigens such as CD3 and CD7. Genome-editing can overcome such hurdles through targeted disruption of problematic shared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd94b2c8d02881014e34c06e90c23e9
https://doi.org/10.1101/2020.07.30.228429
https://doi.org/10.1101/2020.07.30.228429
Autor:
Roland, Preece, Christos, Georgiadis, Soragia Athina, Gkazi, Aniekan, Etuk, Abraham, Christi, Waseem, Qasim
Publikováno v:
Gene therapy. 27(9)
RNA polymerase III (Pol III) promoters express short non-coding RNAs and have been adopted for expression of microRNA, interference RNA, and CRISPR single guide RNA (sgRNA). Vectors incorporating H1 and U6 Pol III promoters are being applied for ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a1cbfcf2f8f68978f42b3e9a9bbb335
https://pubmed.ncbi.nlm.nih.gov/32203198
https://pubmed.ncbi.nlm.nih.gov/32203198
Autor:
Roland Preece, Christos Georgiadis
Publikováno v:
Emerging topics in life sciences. 3(3)
Gene editing tools are being rapidly developed, accelerating many areas of cell and gene therapy research. Each successive gene editing technology promises increased efficacy, improved specificity, reduced manufacturing cost and design complexity; al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f77ef175f8c3acd311dbfc25315a9f
https://pubmed.ncbi.nlm.nih.gov/33523139
https://pubmed.ncbi.nlm.nih.gov/33523139
Publikováno v:
JCI Insight. 3
T cells engineered to express chimeric antigen receptors (CARs) against B cell antigens are being investigated as cellular immunotherapies. Similar approaches designed to target T cell malignancies have been hampered by the critical issue of T-on-T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb4c674e6d55aca4164b4de3f417ec5
https://doi.org/10.1172/jci.insight.99442
https://doi.org/10.1172/jci.insight.99442