Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Roland P.S. Kwok"'
Autor:
Chitra Subramanian, Jason A. Jarzembowski, Anthony W. Opipari, Jr, Valerie P. Castle, Roland P.S. Kwok
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 8, Pp 726-734 (2011)
Ku70 was first characterized as a nuclear factor that binds DNA double-strand breaks in nonhomolog end-joining DNA repair. However, recent studies have shown that Ku70 is also found in the cytoplasm and binds Bax, preventing Bax-induced cell death. W
Externí odkaz:
https://doaj.org/article/4e10ef98375f4129975c15ac748ec97b
Autor:
Chitra Subramanian, Jason A. Jarzembowski, Anthony W. Opipari, Jr., Valerie P. Castle, Roland P.S. Kwok
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 6, Pp 495-503 (2007)
The cytotoxic mechanism of the histone deacetylase inhibitor (HDACI) Trichostatin A (TSA) was explored in a neuroblastoma (NB) model. TSA induces cell death in neuroblastic-type NB cells by increasing the acetylation of Ku70, a Bax-binding protein. K
Externí odkaz:
https://doaj.org/article/e6bc134d5bd141a480523bfa6b1ee43c
Autor:
Michael B. Armstrong, Xin Bian, Yihong Liu, Chitra Subramanian, Anthony B. Ratanaproeksa, Feng Shao, Victor C. Yu, Roland P.S. Kwok, Anthony W. Opipari, Jr., Valerie P. Castle
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 11, Pp 967-977 (2006)
Neuroblastic (N) type neuroblastoma (NB) is the predominant cell type in NB tumors. Previously, we determined that activated nuclear factor κB (NF-κB) is required for doxorubicin and etoposide to kill N-type NB cells. This study was undertaken to d
Externí odkaz:
https://doaj.org/article/f466702252ff403c9931c8e2ba219e47
Autor:
Mengyu Liu, Roland P.S. Kwok, Dexin Sui, Thomas S. Dexheimer, Daniel A. Bochar, Xiexiong Deng, Min Hao Kuo, Stacy Hovde
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
The neurodegenerative Alzheimer’s disease (AD) affects more than 30 million people worldwide. There is thus far no cure or prevention for AD. Aggregation of hyperphosphorylated tau in the brain correlates with the cognitive decline of patients of A
Autor:
Min Hao Kuo, Mengyu Liu, Hsin Lian Lin, Hye Kyong Kweon, Daniela Jimenez-Harrison, Yeou Guang Tsay, Nora Sheen Kuo, Xiexiong Deng, Stacy Hovde, Hsiao Tien Chien, Christopher A. Ayoub, Roland P.S. Kwok, Kuang Wei Wang, Thomas S. Dexheimer, Jeff Kuret, Philip C. Andrews, Daniel A. Bochar, Dexin Sui, Jessica S. Fortin
Publikováno v:
Mol Neurobiol
BackgroundAlzheimer’s disease (AD) is an irreversible neurodegenerative disease without a cure or prevention to date. The defining features of AD include neurofibrillary tangles (NFTs) of hyperphosphorylated tau fibrils, and the senile plaques of
Publikováno v:
Tumour Biology
The first known function of Ku70 is as a DNA repair factor in the nucleus. Using neuronal neuroblastoma cells as a model, we have established that cytosolic Ku70 binds to the pro-apoptotic protein Bax in the cytosol and blocks Bax's cell death activi
CREB-Binding Protein Regulates Ku70 Acetylation in Response to Ionization Radiation in Neuroblastoma
Publikováno v:
Molecular Cancer Research. 11:173-181
Ku70 was originally described as an autoantigen, but it also functions as a DNA repair protein in the nucleus and as an antiapoptotic protein by binding to Bax in the cytoplasm, blocking Bax-mediated cell death. In neuroblastoma (NB) cells, Ku70′s
Autor:
Roland P.S. Kwok, Anthony W. Opipari, Chitra Subramanian, Jason A. Jarzembowski, Valerie P. Castle
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 8, Pp 726-734 (2011)
Ku70 was first characterized as a nuclear factor that binds DNA double-strand breaks in nonhomolog end-joining DNA repair. However, recent studies have shown that Ku70 is also found in the cytoplasm and binds Bax, preventing Bax-induced cell death. W
Publikováno v:
Journal of Endocrinology. 196:89-100
GH activates the c-fos promoter by regulating multiple transcription factors. This study adds to our understanding of GH-regulated transcription by demonstrating that GH regulates the c-fos cAMP-response element (CRE) and its binding protein, CREB. A
Autor:
Graciela Piwien-Pilipuk, Teresa I. Ceseña, Tracy X. Cui, Julianne Kaplani, Jorge A. Iñiguez-Lluhí, Jessica Schwartz, Anda Alexandra Calinescu, Jeffrey S. Huo, Roland P.S. Kwok
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and formation of multiprotein co