Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Roland Nilsson"'
Autor:
Nicolas Sundqvist, Nina Grankvist, Jeramie Watrous, Jain Mohit, Roland Nilsson, Gunnar Cedersund
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1009999 (2022)
Accurate measurements of metabolic fluxes in living cells are central to metabolism research and metabolic engineering. The gold standard method is model-based metabolic flux analysis (MFA), where fluxes are estimated indirectly from mass isotopomer
Externí odkaz:
https://doaj.org/article/5927476bcdb14e47b1fcc9afaedef8e1
Autor:
Mohammad Zulkifli, John K. Neff, Shrishiv A. Timbalia, Natalie M. Garza, Yingqi Chen, Jeramie D. Watrous, Marta Murgia, Prachi P. Trivedi, Steven K. Anderson, Dhanendra Tomar, Roland Nilsson, Muniswamy Madesh, Mohit Jain, Vishal M. Gohil
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Although some fungal mitochondria lack the calcium uniporter, many intriguingly encode homologs of the uniporter assembly factor MCUR1. Here, the authors show that in budding yeast, the MCUR1 homologs Put6 and Put7 regulate mitochondrial proline meta
Externí odkaz:
https://doaj.org/article/389bd4b04d3b4af58e574df071abb507
Autor:
Anna Egerstedt, John Berntsson, Maya Landenhed Smith, Olof Gidlöf, Roland Nilsson, Mark Benson, Quinn S. Wells, Selvi Celik, Carl Lejonberg, Laurie Farrell, Sumita Sinha, Dongxiao Shen, Jakob Lundgren, Göran Rådegran, Debby Ngo, Gunnar Engström, Qiong Yang, Thomas J. Wang, Robert E. Gerszten, J. Gustav Smith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Heart failure is a major health issue worldwide. Here, Egerstedt et al. perform proteomic profiling of human plasma at different stages of heart failure, providing a comprehensive analysis of changes in the plasma proteome during disease progression.
Externí odkaz:
https://doaj.org/article/8631686d85f7447fbe8d13055384ccaf
Autor:
Ganna Oliynyk, María Victoria Ruiz-Pérez, Lourdes Sainero-Alcolado, Johanna Dzieran, Hanna Zirath, Héctor Gallart-Ayala, Craig E. Wheelock, Henrik J. Johansson, Roland Nilsson, Janne Lehtiö, Marie Arsenian-Henriksson
Publikováno v:
iScience, Vol 21, Iss , Pp 188-204 (2019)
Summary: In pediatric neuroblastoma, MYCN-amplification correlates to poor clinical outcome and new treatment options are needed for these patients. Identifying the metabolic adaptations crucial for tumor progression may be a promising strategy to di
Externí odkaz:
https://doaj.org/article/30c5f535984240819ada19e400058301
Autor:
Costas Koufaris, Roland Nilsson
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as a potential cancer therapeutic target. However, recent evidence suggests t
Externí odkaz:
https://doaj.org/article/52a0ea79cac844ff9c3e35fd51042d55
Autor:
María Victoria Ruiz-Pérez, Lourdes Sainero-Alcolado, Ganna Oliynyk, Isabell Matuschek, Nicola Balboni, S.J. Kumari A. Ubhayasekera, Marteinn Thor Snaebjornsson, Kamil Makowski, Kristina Aaltonen, Daniel Bexell, Dolors Serra, Roland Nilsson, Jonas Bergquist, Almut Schulze, Marie Arsenian-Henriksson
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102128- (2021)
Summary: Many metabolic pathways, including lipid metabolism, are rewired in tumors to support energy and biomass production and to allow adaptation to stressful environments. Neuroblastoma is the second deadliest solid tumor in children. Genetic abe
Externí odkaz:
https://doaj.org/article/fdcde282d39e41aa9c4af63f5a3e2e3b
Autor:
Irena Roci, Jeramie D. Watrous, Kim A. Lagerborg, Lorenzo Lafranchi, Arne Lindqvist, Mohit Jain, Roland Nilsson
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1691-1700.e5 (2019)
Summary: Alterations in cell-cycle regulation and cellular metabolism are associated with cancer transformation, and enzymes active in the committed cell-cycle phase may represent vulnerabilities of cancer cells. Here, we map metabolic events in the
Externí odkaz:
https://doaj.org/article/7b10a39363e0477dbac11342bc364153
Autor:
Joshua M. Baughman, Roland Nilsson, Vishal M. Gohil, Daniel H. Arlow, Zareen Gauhar, Vamsi K. Mootha
Publikováno v:
PLoS Genetics, Vol 6, Iss 3 (2010)
Externí odkaz:
https://doaj.org/article/fd8ae3aa301e4a628989952cfdbc67fd
Autor:
Sara Hägg, Josefin Skogsberg, Jesper Lundström, Peri Noori, Roland Nilsson, Hua Zhong, Shohreh Maleki, Ming-Mei Shang, Björn Brinne, Maria Bradshaw, Vladimir B Bajic, Ann Samnegård, Angela Silveira, Lee M Kaplan, Bruna Gigante, Karin Leander, Ulf de Faire, Stefan Rosfors, Ulf Lockowandt, Jan Liska, Peter Konrad, Rabbe Takolander, Anders Franco-Cereceda, Eric E Schadt, Torbjörn Ivert, Anders Hamsten, Jesper Tegnér, Johan Björkegren
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000754 (2009)
Environmental exposures filtered through the genetic make-up of each individual alter the transcriptional repertoire in organs central to metabolic homeostasis, thereby affecting arterial lipid accumulation, inflammation, and the development of coron
Externí odkaz:
https://doaj.org/article/a36a7f46d91547e2bc0f1a6cf6f69acd
Autor:
Joshua M Baughman, Roland Nilsson, Vishal M Gohil, Daniel H Arlow, Zareen Gauhar, Vamsi K Mootha
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000590 (2009)
The human oxidative phosphorylation (OxPhos) system consists of approximately 90 proteins encoded by nuclear and mitochondrial genomes and serves as the primary cellular pathway for ATP biosynthesis. While the core protein machinery for OxPhos is wel
Externí odkaz:
https://doaj.org/article/566fc7fd4a704dcd84fd1699d929f3a1