Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Roland Nicsanu"'
Autor:
Claudia Saraceno, Carlo Cervellati, Alessandro Trentini, Daniela Crescenti, Antonio Longobardi, Andrea Geviti, Natale Salvatore Bonfiglio, Sonia Bellini, Roland Nicsanu, Silvia Fostinelli, Gianmarco Mola, Raffaella Riccetti, Davide Vito Moretti, Orazio Zanetti, Giuliano Binetti, Giovanni Zuliani, Roberta Ghidoni
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8354 (2024)
Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are the two major neurodegenerative diseases causing dementia. Due to similar clinical phenotypes, differential diagnosis is challenging without specific biomarkers. Beta-site Amyloid Precu
Externí odkaz:
https://doaj.org/article/c24cafcaac18472a917afc21452760b6
Autor:
Antonio Longobardi, Sonia Bellini, Roland Nicsanu, Andrea Pilotto, Andrea Geviti, Alessandro Facconi, Chiara Tolassi, Ilenia Libri, Claudia Saraceno, Silvia Fostinelli, Barbara Borroni, Alessandro Padovani, Giuliano Binetti, Roberta Ghidoni
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7457 (2024)
Alzheimer’s disease (AD) and Frontotemporal lobar degeneration (FTLD) represent the most common forms of neurodegenerative dementias with a highly phenotypic variability. Herein, we investigated the role of genetic variants related to the immune sy
Externí odkaz:
https://doaj.org/article/b1cd42f351df481da36568aef411147d
Autor:
Emiliano Giardina, Paola Mandich, Roberta Ghidoni, Nicola Ticozzi, Giacomina Rossi, Chiara Fenoglio, Francesco Danilo Tiziano, Federica Esposito, Sabina Capellari, Benedetta Nacmias, Rossana Mineri, Rosa Campopiano, Luana Di Pilla, Federica Sammarone, Stefania Zampatti, Cristina Peconi, Flavio De Angelis, Ilaria Palmieri, Caterina Galandra, Eleonora Nicodemo, Paola Origone, Fabio Gotta, Clarissa Ponti, Roland Nicsanu, Luisa Benussi, Silvia Peverelli, Antonia Ratti, Martina Ricci, Giuseppe Di Fede, Stefania Magri, Maria Serpente, Serena Lattante, Teuta Domi, Paola Carrera, Elisa Saltimbanco, Silvia Bagnoli, Assunta Ingannato, Alberto Albanese, Fabrizio Tagliavini, Raffaele Lodi, Carlo Caltagirone, Stefano Gambardella, Enza Maria Valente, Vincenzo Silani
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionHigh repeat expansion (HRE) alleles in C9orf72 have been linked to both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); ranges for intermediate allelic expansions have not been defined yet, and clinical interpretati
Externí odkaz:
https://doaj.org/article/48c2074ccdf6430aa36dbc406509d0c2
Autor:
Antonio Longobardi, Marcella Catania, Andrea Geviti, Erika Salvi, Elena Rita Vecchi, Sonia Bellini, Claudia Saraceno, Roland Nicsanu, Rosanna Squitti, Giuliano Binetti, Giuseppe Di Fede, Roberta Ghidoni
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1125 (2024)
The accumulation of protein aggregates defines distinct, yet overlapping pathologies such as Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). In this study, we investigated ATG5, UBQLN2, ULK1, and LC3 co
Externí odkaz:
https://doaj.org/article/fe73e6d693cc47ad8b7037bc04cedbe9
Autor:
Giacomina Rossi, Erika Salvi, Luisa Benussi, Elkadia Mehmeti, Andrea Geviti, Sonia Bellini, Antonio Longobardi, Alessandro Facconi, Matteo Carrara, Cristian Bonvicini, Roland Nicsanu, Claudia Saraceno, Martina Ricci, Giorgio Giaccone, Giuliano Binetti, Roberta Ghidoni
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12847 (2022)
Genetic frontotemporal lobar degeneration (FTLD) is characterized by heterogeneous phenotypic expression, with a disease onset highly variable even in patients carrying the same mutation. Herein we investigated if variants in lysosomal genes modulate
Externí odkaz:
https://doaj.org/article/65cc3c80112c4c609be9062684a2714c
Autor:
Sonia Bellini, Claudia Saraceno, Luisa Benussi, Andrea Geviti, Antonio Longobardi, Roland Nicsanu, Sara Cimini, Martina Ricci, Laura Canafoglia, Cinzia Coppola, Gianfranco Puoti, Giuliano Binetti, Giacomina Rossi, Roberta Ghidoni
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10693 (2022)
Emerging data suggest the roles of endo-lysosomal dysfunctions in frontotemporal lobar degeneration (FTLD) and in other dementias. Cathepsin D is one of the major lysosomal proteases, mediating the degradation of unfolded protein aggregates. In this
Externí odkaz:
https://doaj.org/article/ad546297590c41e48546528c09493221
Autor:
Guido Domingo, Luisa Benussi, Claudia Saraceno, Michela Bertuzzi, Roland Nicsanu, Antonio Longobardi, Sonia Bellini, Alfredo Cagnotto, Mario Salmona, Giuliano Binetti, Roberta Ghidoni
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Alzheimer’s disease (AD) is a pathology characterized by the accumulation in the brain of intracellular and extracellular amyloid-β (Aβ) aggregates, especially of Aβ1–40 and Aβ1–42 peptides. It is known that N-terminally truncated or modifi
Externí odkaz:
https://doaj.org/article/d12cc86340c14def8a5fb846b2682e52
Autor:
Antonio Longobardi, Luisa Benussi, Roland Nicsanu, Sonia Bellini, Clarissa Ferrari, Claudia Saraceno, Roberta Zanardini, Marcella Catania, Giuseppe Di Fede, Rosanna Squitti, Giuliano Binetti, Roberta Ghidoni
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Alzheimer’s disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) are the three major neurodegenerative dementias. In this study, we provide evidence that an alteration in extracellular vesicles (EVs) release is common ac
Externí odkaz:
https://doaj.org/article/c67abb90d12c461887e0d76b551c50b0
Autor:
Antonio Longobardi, Roland Nicsanu, Sonia Bellini, Rosanna Squitti, Marcella Catania, Pietro Tiraboschi, Claudia Saraceno, Clarissa Ferrari, Roberta Zanardini, Giuliano Binetti, Giuseppe Di Fede, Luisa Benussi, Roberta Ghidoni
Publikováno v:
Cells, Vol 11, Iss 3, p 462 (2022)
Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) represent the three major neurodegenerative dementias characterized by abnormal brain protein accumulation. In this study, we investigated extracellular ves
Externí odkaz:
https://doaj.org/article/6d67c436a316484191d4f7f84a837cc6
Autor:
Sonia Bellini, Claudia Saraceno, Luisa Benussi, Rosanna Squitti, Sara Cimini, Martina Ricci, Laura Canafoglia, Cinzia Coppola, Gianfranco Puoti, Clarissa Ferrari, Antonio Longobardi, Roland Nicsanu, Marta Lombardi, Giulia D’Arrigo, Claudia Verderio, Giuliano Binetti, Giacomina Rossi, Roberta Ghidoni
Publikováno v:
Cells, Vol 11, Iss 3, p 488 (2022)
Cutting-edge research suggests endosomal/immune dysregulation in GRN/C9orf72-associated frontotemporal lobar degeneration (FTLD). In this retrospective study, we investigated plasma small extracellular vesicles (sEVs) and complement proteins in 172 s
Externí odkaz:
https://doaj.org/article/9cb9c4f4e14148ff9babc6e223ffc941