Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Roland Mory"'
Autor:
Katrin Groebke Zbinden, Claas A. Meyer, Jean-Luc Moreau, Tatyana D. Sotnikova, Sean Durkin, Bernhard Bettler, Florent G. Revel, Sylvie Chaboz, Bruno Pouzet, Roger David Norcross, Amyaouch Bradaia, Raul R. Gainetdinov, Marc G. Caron, Marius C. Hoener, Veit Metzler, Laurence Ozmen, Gerhard Trube, Joseph G. Wettstein, Roland Mory
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and β-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promisi
Publikováno v:
Pharmacology Biochemistry and Behavior. 97:185-191
Multiple lines of evidence support the notion that hypofunction of glutamatergic neurotransmission is involved in the pathophysiology of schizophrenia. Moreover, glycine and glycine modulators have beneficial effects in patients with schizophrenia, p
Autor:
Emmanuel Pinard, Sabine Kolczewski, Serge Burner, Daniela Alberati, Holger Fischer, Henri Stalder, Judith Lengyel, Tanja Schulz-Gasch, Christian Saladin, Nicole Hauser, Virginie Brom, Roland Mory, Rubén Alvarez-Sánchez
3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure–activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e89e3d927b1260f6bbbc64f35dcc2b8
https://europepmc.org/articles/PMC4027785/
https://europepmc.org/articles/PMC4027785/
Autor:
Danièle Buchy, Amyaouch Bradaia, Guido Galley, D Tuerck, J-L Moreau, Roland Mory, Marius C. Hoener, Stephen R. Morairty, Veit Metzler, K Groebke Zbinden, Thomas S. Kilduff, Tanya L. Wallace, Joseph G. Wettstein, Andreas Bruns, Bruno Pouzet, Sylvie Chaboz, R D Norcross, Celine Risterucci, Florent G. Revel
Publikováno v:
Molecular psychiatry. 18(5)
Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative and cognitive symptoms, two prominent features of the disease with critical impact on the
Autor:
Edilio Borroni, Hans-Peter Marty, Philipp Schmid, Judith Lengyel, Serge Burner, Nicole Hauser, Jean-Luc Moreau, Robert Narquizian, Roger Wermuth, Virginie Brom, Remy Halm, Holger Fischer, Emmanuel Pinard, Markus Bender, Roger David Norcross, Synese Jolidon, Dominik Hainzl, Thierry Meyer, Roland Mory, Daniela Alberati, Daniel Zimmerli
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(23)
Benzoylisoindolines were discovered as a novel structural class of GlyT1 inhibitors. SAR studies and subsequent lead optimization efforts focused primarily on addressing hERG liability and on improving in vivo efficacy resulted in the identification
Autor:
Emmanuel Pinard, Dominik Hainzl, Hans-Peter Marty, Robert Narquizian, Virginie Brom, Roger Wermuth, Roland Mory, Alexander Alanine, Roger David Norcross, Philipp Schmid, Henri Stalder, Jean-Luc Moreau, Judith Lengyel, Joseph G. Wettstein, Holger Fischer, Markus Bender, Bernd Puellmann, Daniel Zimmerli, Synese Jolidon, Sebastien Schmitt, Thierry Meyer, Edilio Borroni, Mathias Nettekoven, Patrick Bourdeaux, Remy Halm, Nicole Hauser, Daniela Alberati, Serge Burner
Publikováno v:
Journal of medicinal chemistry. 53(12)
The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia. Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine class of GlyT1 inhibitors to improve hERG channel selectivity and brain
Publikováno v:
Behavioural Pharmacology. 11:342
Rationale. Neonatal ventral hippocampal lesions in rats have been shown to result in behavioral abnormalities at adulthood thought to simulate some aspects of positive and cognitive deficits classically observed in schizophrenic patients. Objectives.