Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Roland M Huber"'
Autor:
Roland M Huber, Michal Rajski, Balasubramanian Sivasankaran, Gerald Moncayo, Brian A Hemmings, Adrian Merlo
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57793 (2013)
Glioblastoma (GBM) is a highly malignant primary tumor of the central nervous system originating in glial cells. GBM results in more years of life lost than any other cancer type. Low levels of Notch receptor expression correlates with prolonged surv
Externí odkaz:
https://doaj.org/article/b325cbee6cc34797837dff071908db3b
Autor:
Serdar Korur, Roland M Huber, Balasubramanian Sivasankaran, Michael Petrich, Pier Morin, Brian A Hemmings, Adrian Merlo, Maria Maddalena Lino
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7443 (2009)
Cancers are driven by a population of cells with the stem cell properties of self-renewal and unlimited growth. As a subpopulation within the tumor mass, these cells are believed to constitute a tumor cell reservoir. Pathways controlling the renewal
Externí odkaz:
https://doaj.org/article/a73b49b97ab54183acd4431e96a2dfa8
Autor:
Venkateswar Jarugula, Yan-Ling He, Anisha E. Mendonza, Markus Walles, Lydia Wang-Lakshman, Roland M. Huber
Absorption, metabolism, and excretion (AME) of licogliflozin, a sodium-glucose co-transporters (SGLTs) 1 and 2 inhibitor, were studied in male rats, dogs, and healthy male volunteers and reported.Oral absorption of licogliflozin was rapid (tmax < 1 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7786ac62516b54779daf88fb83712fe7
Autor:
Ola Bunte, Ronenn Roubenoff, Julian Fürmetz, Daniel Rooks, Wolfgang Böcker, Jens Praestgaard, Matthias Schieker, Arne Mueller, Lorcan Walsh, Roland M. Huber, Alexander M. Keppler, Amir Muaremi, Ieuan Clay, Sophie Brachat, Holger Hoefling
Publikováno v:
JMIR mHealth and uHealth
JMIR mHealth and uHealth, Vol 7, Iss 11, p e15191 (2019)
JMIR mHealth and uHealth, Vol 7, Iss 11, p e15191 (2019)
Background Digital technologies and advanced analytics have drastically improved our ability to capture and interpret health-relevant data from patients. However, only limited data and results have been published that demonstrate accuracy in target i
Autor:
Tatiana Smirnova, Roland M. Huber, Yuhua Wang, Adrian Merlo, Nancy E. Hynes, Hans-Rudolf Hotz, Michal Grzmil, Gerald Moncayo, Brian A. Hemmings, Stephan Frank, Debby Hynx, Georg B. Keller, Hubertus Kohler, Pawel Zmarz
Publikováno v:
Neuro-oncology. 20(5)
Background Glioblastoma (GBM) is one of the most aggressive human brain tumors, with a median survival of 15-18 months. There is a desperate need to find novel therapeutic targets. Various receptor protein kinases have been identified as potential ta
Autor:
Jared M. Lucas, Roger Coleman, Luis A. Gomez-Sarosi, Song Zhao, Peter S. Nelson, Ilsa Coleman, Roland M. Huber
Publikováno v:
Oncotarget
Though metastatic cancers often initially respond to genotoxic therapeutics, acquired resistance is common. In addition to cytotoxic effects on tumor cells, DNA damaging agents such as ionizing radiation and chemotherapy induce injury in benign cells
Publikováno v:
Neuron. 55(5):726-740
SummaryAccumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei under
Autor:
Gerald Moncayo, Debby Hynx, Brian A. Hemmings, Michal Grzmil, Daniel Hess, Adrian Merlo, Dominique Klein, Stephan Frank, Roland M. Huber
High levels of mammalian target of rapamycin complex 1 (mTORC1) activity in malignant gliomas promote tumor progression, suggesting that targeting mTORC1 has potential as a therapeutic strategy. Remarkably, clinical trials in patients with glioma rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcddf354a2cbf2b45634b01f92ace11
https://europepmc.org/articles/PMC3904612/
https://europepmc.org/articles/PMC3904612/
Autor:
Balasubramanian Sivasankaran, Mercedes Tomé, Dimitri Cloëtta, Martin Gassmann, Adrian Merlo, Frank Kirchhoff, Nicole Schaeren-Wiemers, Michal Grzmil, Roland M. Huber, Jan S. Tchorz, Bernhard Bettler, F Rutz-Schatzmann, Brian A. Hemmings
Publikováno v:
Cell Death & Disease
Cell death & disease
Cell death & disease
Recent studies identified a highly tumorigenic subpopulation of glioma stem cells (GSCs) within malignant gliomas. GSCs are proposed to originate from transformed neural stem cells (NSCs). Several pathways active in NSCs, including the Notch pathway,
Autor:
Maria Maddalena Lino, Serdar Korur, Roland M. Huber, Michael Petrich, Adrian Merlo, Pier Morin, Balasubramanian Sivasankaran, Brian A. Hemmings
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7443 (2009)
PLoS ONE
PLoS ONE
Cancers are driven by a population of cells with the stem cell properties of self-renewal and unlimited growth. As a subpopulation within the tumor mass, these cells are believed to constitute a tumor cell reservoir. Pathways controlling the renewal