Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Roland Kousek"'
Autor:
Thomas Scott, Christian Alan Paul Smethurst, Yvonne Westermaier, Moriz Mayer, Peter Greb, Roland Kousek, Tobias Biberger, Gerd Bader, Zuzana Jandova, Philipp S. Schmalhorst, Julian E. Fuchs, Aniket Magarkar, Christoph Hoenke, Thomas Gerstberger, Steven A. Combs, Richard Pape, Saksham Phul, Sandeepkumar Kothiwale, Andreas Bergner, Alex G. Waterson, Foldit Players, Harald Weinstabl, Darryl B. McConnell, Jark Böttcher, Jens Meiler, Rocco Moretti
Given the role of human intuition in current drug design efforts, crowd-sourced 'citizen scientist' games have the potential to greatly expand the pool of potential drug designers. Here, we introduce ‘Drugit', the small molecule design mode of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::287b3949d9d0ebf819f483d064d56529
https://doi.org/10.26434/chemrxiv-2023-lczzd
https://doi.org/10.26434/chemrxiv-2023-lczzd
Autor:
Roland Kousek, Dirk Kessler, Stephan Karl Zahn, Jens Bruchhaus, Darryl B. McConnell, Mark Pearson, Franziska Moser, Bernhard Wolkerstorfer, Dennis Breitsprecher, Maximilian Scharnweber, Teresa Puchner, Georg Dahmann, Philipp Baaske, Julian E. Fuchs, Sandra Döbel, Wolfgang Hela, Christiane Kofink, Klaus Rumpel, Leonhard Geist, Simon Wöhrle, Andreas Bergner, Moriz Mayer, Jark Böttcher, Patrick Werni, Markus Zeeb, Maike Dettling, Tuncay Ciftci
Publikováno v:
Chemmedchem
Aberrant WNT pathway activation, leading to nuclear accumulation of β‐catenin, is a key oncogenic driver event. Mutations in the tumor suppressor gene APC lead to impaired proteasomal degradation of β‐catenin and subsequent nuclear translocatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bddd2c4cb79fde7e745f2b35f2c8e2
https://doi.org/10.1002/cmdc.202000839
https://doi.org/10.1002/cmdc.202000839
Autor:
Zhulin Tan, Nitinchandra D. Patel, Harald Engelhardt, Mark Petronczki, Georg Egger, Elisabeth Grondal, Lyne Lamarre, Joyce C. Leung, Bernadette Sharps, Nizar Haddad, Anke Baum, Andreas Bergner, Andreas Schrenk, Renate Schnitzer, Eugene Chong, Tobias Wunberg, Moriz Mayer, Thomas Gerstberger, Dietrich Böse, Andreas Zoephel, Darryl B. McConnell, Christian Engelhardt, Monika Kriz, Nina C. Gonnella, Mariusz Krawiec, Heinz Stadtmüller, Peter Ettmayer, Jonathan T. Reeves, Julian E. Fuchs, Barbara Hopfgartner, Dirk Scharn, Andreas Grimm, Biljana Peric Simov, Flavio Solca, Gerd Bader, Sandra Döbel, Roland Kousek
Publikováno v:
Journal of Medicinal Chemistry. 62:10272-10293
The epidermal growth factor receptor (EGFR), when carrying an activating mutation like del19 or L858R, acts as an oncogenic driver in a subset of lung tumors. While tumor responses to tyrosine kinase inhibitors (TKIs) are accompanied by marked tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d9f6cbebee7f9e20944c7e79b6bc3f
https://doi.org/10.1021/acs.jmedchem.9b01169
https://doi.org/10.1021/acs.jmedchem.9b01169
Autor:
Yvonne Scherbantin, Gerd Bader, thomas Fett, Harald Weinstabl, Sophie Mitzner, Tuncay Ciftci, Bernhard Wolkerstorfer, Jens Bruchhaus, Xiaobing Lv, Dongyang Li, Bernadette Sharps, Daniela Haering, Heribert Arnhof, Nikolai Mischerikow, Geraldine Garavel, Andreas Schrenk, Joerg Rinnenthal, Roland Kousek, Thomas Gerstberger, Guido Scholz, Stephan Karl Zahn, Paola Martinelli, Jens Quant, Renate Schnitzer, Andreas Zoephel, Darryl B. McConnell, Moriz Mayer, Dirk Kessler, Xuechun Zhang, Michelle Burkard, Mark Pearson, Karin S. Hofbauer, Alicia Du, Matthias Treu, Christoph Harrer, Yali Li, Fabio Savarese, Klaus Rumpel, Biljana Peric-Simov, Georg Dahmann, Wolfgang Sommergruber, Peter Ettmayer
Publikováno v:
Journal of Medicinal Chemistry. 62:7976-7997
Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate-limiting enzyme in the serine synthesis pathway in humans. It converts glycolysis-derived 3-phosphoglycerate to 3-phosphopyruvate in a co-factor-dependent oxidation reaction. Herein, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aae2be102afb8dc581630c149133ec0d
https://doi.org/10.1021/acs.jmedchem.9b00718
https://doi.org/10.1021/acs.jmedchem.9b00718
Autor:
Andreas Schrenk, Daniela Häring, Silke Fischer, Stefan Kornigg, Alex G. Waterson, Andreas Mantoulidis, Manfred Koegl, Markus Zeeb, Thomas Gerstberger, Mark Pearson, Wolfgang Hela, Andreas Zoephel, Darryl B. McConnell, Michael Gmachl, Bernadette Sharps, Jale Karolyi-Oezguer, Johann Hoffmann, Franziska Moser, Jason Phan, Teresa Gmaschitz, David Covini, Bernhard Wolkerstorfer, Qi Sun, Lyne Lamarre, Gabriella Siszler, Renate Schnitzer, Moriz Mayer, Dirk Kessler, Katharina Schipany, Petr Knesl, Christian Salamon, Peter Greb, Stephen W. Fesik, Andreas Gollner, Yvonne Scherbantin, Silvia Munico-Martinez, Craig M. Goodwin, Roland Kousek, Jörg Rinnenthal, Jiqing Sai, Christoph Peinsipp, Laetitia J. Martin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Despite decades of research, no approved drugs have been discovered for KRAS. Recently, a pocket occurring on the surface of the active and inactive form of KRAS was found, but, due to its comparatively shallow, polar nature, this pocket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb3a3b7c6eb6eb9f74dfaa7050cde56
https://pubmed.ncbi.nlm.nih.gov/32047043
https://pubmed.ncbi.nlm.nih.gov/32047043
Autor:
Gabriella Siszler, Andreas Bergner, Barbara Müllauer, Andreas Mantoulidis, Laetitia J. Martin, Andreas Gollner, Darryl B. McConnell, Bernhard Wolkerstorfer, Xiao-Ling Cockcroft, Moriz Mayer, Dirk Kessler, Wolfgang Hela, Gerhard Fischer, Roland Kousek
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Natural products have proven to be a rich source of molecular architectures for drugs. Here, an integrated approach to natural product screening is proposed, which uncovered eight new natural product scaffolds for KRAS—the most frequently mutated o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76863501a4fb5d279835adefcd8a8f8
https://pubmed.ncbi.nlm.nih.gov/31231840
https://pubmed.ncbi.nlm.nih.gov/31231840
Autor:
Andreas Gollner, Dirk Kessler, Andreas Mantoulidis, Darryl B. McConnell, Bernhard Wolkerstorfer, Gabriella Siszler, Barbara Müllauer, Andreas Bergner, Roland Kousek, Wolfgang Hela, Laetitia J. Martin, Moriz Mayer, Gerhard Fischer, Xiao-Ling Cockcroft
Publikováno v:
Chemistry – A European Journal. 25:11998-11998
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0442b83d758074e821c739a5fad0548a
https://doi.org/10.1002/chem.201903597
https://doi.org/10.1002/chem.201903597
Autor:
Alexander Stadler, Darryl B. McConnell, Thomas Karner, Matthias Treu, Helmut Berger, Roland Kousek, Moriz Mayer
Publikováno v:
ChemInform. 40
New rotor types using disposable glass vials for small-scale parallel synthesis in multimode microwave reactors are introduced. One rotor comprises 16 groups of four vials, whereas the second uses four silicon carbide plates with a 6 × 4 matrix to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7697130d5f7c83729c66d06ae2851800
https://doi.org/10.1002/chin.200913031
https://doi.org/10.1002/chin.200913031
Autor:
Roland Kousek, Matthias Treu, Thomas Karner, Darryl B. McConnell, Alexander Stadler, Helmut Berger, Moriz Mayer
Publikováno v:
Journal of combinatorial chemistry. 10(6)
New rotor types using disposable glass vials for small-scale parallel synthesis in multimode microwave reactors are introduced. One rotor comprises 16 groups of four vials, whereas the second uses four silicon carbide plates with a 6 x 4 matrix to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47beb50b85408f0cfa3f8556fe2d7665
https://pubmed.ncbi.nlm.nih.gov/18808188
https://pubmed.ncbi.nlm.nih.gov/18808188
Autor:
Matthias Treu, Thomas Karner, Roland Kousek, Helmut Berger, Moriz Mayer, Darryl B. McConnell, Alexander Stadler
Publikováno v:
Journal of Combinatorial Chemistry. Oct2008, Vol. 10 Issue 6, p863-868. 6p.