Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Roland K. Strong"'
Autor:
Jennifer N. Wacker, Joshua J. Woods, Peter B. Rupert, Appie Peterson, Marc Allaire, Wayne W. Lukens, Alyssa N. Gaiser, Stefan G. Minasian, Roland K. Strong, Rebecca J. Abergel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Targeted alpha therapy (TAT) pairs the specificity of antigen targeting with the lethality of alpha particles to eradicate cancerous cells. Actinium-225 [225Ac; t1/2 = 9.920(3) days] is an alpha-emitting radioisotope driving the next generat
Externí odkaz:
https://doaj.org/article/b852e100a7e24175a5eaf16faeb613d7
Autor:
Peter B. Rupert, Matthew Buerger, Emily J. Girard, Marie Frutoso, Don Parrilla, Kevin Ng, Theodore Gooley, Veronika Groh, Roland K. Strong
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28583- (2024)
NKG2D and its ligands are critical regulators of protective immune responses controlling infections and cancer, defining a crucial immune signaling axis. Current therapeutic efforts targeting this axis almost exclusively aim at enhancing NKG2D-mediat
Externí odkaz:
https://doaj.org/article/ff64ffa78a71418689ec662a6f844c00
Autor:
William Chour, Jongchan Choi, Jingyi Xie, Mary E. Chaffee, Thomas M. Schmitt, Kathryn Finton, Diana C. DeLucia, Alexander M. Xu, Yapeng Su, Daniel G. Chen, Rongyu Zhang, Dan Yuan, Sunga Hong, Alphonsus H. C. Ng, Jonah Z. Butler, Rick A. Edmark, Lesley C. Jones, Kim M. Murray, Songming Peng, Guideng Li, Roland K. Strong, John K. Lee, Jason D. Goldman, Philip D. Greenberg, James R. Heath
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract The discovery and characterization of antigen-specific CD8+ T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers. We adapt single-chain trimer (SCT) technologies into a high throughput
Externí odkaz:
https://doaj.org/article/3bdea162be0a4447904d5af92d6a6730
Autor:
Ida Lin, Peter B. Rupert, Kristina Pilat, Raymond O. Ruff, Della J. Friend, Man Kid Chan, Midori Clarke, Benjamin G. Hoffstrom, Jane Carter, Soheil Meshinchi, Ashok D. Bandaranayake, Christopher Mehlin, James M. Olson, Roland K. Strong, Colin E. Correnti
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Mesothelin is a glypiated, cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed by many cancers. Implicated in cell adhesion and multiple signaling pathways, mesothelin’s precise biological function and overall
Externí odkaz:
https://doaj.org/article/4119894bb87a422e91bef3d667f1bb92
Autor:
Kathryn A. K. Finton, Peter B. Rupert, Della J. Friend, Ana Dinca, Erica S. Lovelace, Matthew Buerger, Domnita V. Rusnac, Ulysses Foote-McNabb, William Chour, James R. Heath, Jean S. Campbell, Robert H. Pierce, Roland K. Strong
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
MHC class I “single-chain trimer” molecules, coupling MHC heavy chain, β2-microglobulin, and a specific peptide into a single polypeptide chain, are widely used in research. To more fully understand caveats associated with this design that may a
Externí odkaz:
https://doaj.org/article/738bbd7365bf4134a8132bf3cd7b009a
ARTEMIS: A Novel Mass-Spec Platform for HLA-Restricted Self and Disease-Associated Peptide Discovery
Autor:
Kathryn A. K. Finton, Mi-Youn Brusniak, Lisa A. Jones, Chenwei Lin, Andrew J. Fioré-Gartland, Chance Brock, Philip R. Gafken, Roland K. Strong
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Conventional immunoprecipitation/mass spectroscopy identification of HLA-restricted peptides remains the purview of specializing laboratories, due to the complexity of the methodology, and requires computational post-analysis to assign peptides to in
Externí odkaz:
https://doaj.org/article/424db8037b354d329815ddf12d2a043d
Autor:
Zachary R. Crook, Gregory P. Sevilla, Della Friend, Mi-Youn Brusniak, Ashok D. Bandaranayake, Midori Clarke, Mesfin Gewe, Andrew J. Mhyre, David Baker, Roland K. Strong, Philip Bradley, James M. Olson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Pathologies related to protein:protein interaction are hard to treat but cystine-dense peptides have the potential to disrupt such interactions. Here the authors develop a high-diversity mammalian cell screen for cystine-dense peptides with drug pote
Externí odkaz:
https://doaj.org/article/68a2dc186894404db175693588126a0e
Autor:
Xin Cai, Andrea Caballero-Benitez, Mesfin M. Gewe, Isaac C. Jenkins, Charles W. Drescher, Roland K. Strong, Thomas Spies, Veronika Groh
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 6, Pp 471-482 (2017)
Cancer cells may co-opt the NKG2D lymphocyte receptor to complement the presence of its ligands for autonomous stimulation of oncogenic signaling. Previous studies raise the possibility that cancer cell NKG2D may induce high malignancy traits, but it
Externí odkaz:
https://doaj.org/article/2c17f47a47504a45a810221931308fad
Autor:
Matthew C. Clifton, Peter B. Rupert, Trisha M. Hoette, Kenneth N. Raymond, Rebecca J. Abergel, Roland K. Strong
Publikováno v:
Journal of Structural Biology: X, Vol 2, Iss , Pp - (2019)
Siderocalin/Lipocalin 2/Neutrophil Gelatinase Associated Lipocalin/24p3 is an innate immune system protein with bacteriostatic activity, acting by tightly binding and sequestering diverse catecholate and mixed-type ferric siderophores from enteric ba
Externí odkaz:
https://doaj.org/article/19f4706a2fbd4910b68af3fc9a07266d
Autor:
Jonathan Barasch, Maria Hollmen, Rong Deng, Eldad A. Hod, Peter B. Rupert, Rebecca J. Abergel, Benjamin E. Allred, Katherine Xu, Shaun F. Darrah, Yared Tekabe, Alan Perlstein, Rebecca Wax, Efrat Bruck, Jacob Stauber, Kaitlyn A. Corbin, Charles Buchen, Vesna Slavkovich, Joseph Graziano, Steven L. Spitalnik, Guanhu Bao, Roland K. Strong, Andong Qiu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demo
Externí odkaz:
https://doaj.org/article/3ae332e27072492dad5e0ff733401a56