Zobrazeno 1 - 10
of 632
pro vyhledávání: '"Roland K. Robins"'
Autor:
Donald F Smee, Howard B Cottam, Brahma S Sharma, Ganesh D Kini, Ganapathi R Revankar, Emmanuel A Ojo-Amaize, Robert W Sidwell, Weldon B Jolley, Roland K Robins
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 3, Iss Suppl B, Pp 41-48 (1992)
7-thia-8-oxoguanosine (TOGuo) is the first reported structure of a family of modified guanosine analogues exhibiting antiviral activity in rodent models. Its spectrum of action includes interferon-sensitive viruses such as alphaviruses, bunyaviruses,
Externí odkaz:
https://doaj.org/article/c4c9e5228dba4f8a9eceddc11c64aceb
Autor:
Robert W Sidwell, John H Huffman, Donald F Smee, John Gilbert, Roland K Robins, Meir Kende, John Huggins
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 3, Iss Suppl B, Pp 49-54 (1992)
Biological response modifiers (BRMs) have particular promise when used in combination with more standard antiviral agents for treatment of viral diseases. Reported here are a series of studies which have used two BRMs in combination with the antivira
Externí odkaz:
https://doaj.org/article/df2fc1d85cfb417189d9bcf763b5dd03
Autor:
Daniel W. Miles, Michael W. Winkley, Morris J. Robins, Roland K. Robins, Henry Eyring, Warren H. Inskeep
Publikováno v:
International Journal of Quantum Chemistry. 3:129-145
The electronic structures and spectra of some simple nucleoside derivatives with the formal structure of cytosine nucleoside are presented. The experimental spectroscopic information is obtained from the circular dichroism and absorption spectra. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08549dab656f66291a5abfbb4b633a4
https://doi.org/10.1002/qua.560030718
https://doi.org/10.1002/qua.560030718
Publikováno v:
Journal of Heterocyclic Chemistry. 28:1779-1788
Several disubstituted pyrazolo[3,4-d]pyrimidine, pyrazolo[1,5-a]pyrimidine and thiazolo[4,5-d]pyrimidine ribonucleosides have been prepared as congeners of uridine and cytidine. Glycosylation of the trimethylsilyl (TMS) derivative of pyrazolo[3,4-d]p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d0a0a8ed0f26230becea3928a3f5769
https://doi.org/10.1002/jhet.5570280722
https://doi.org/10.1002/jhet.5570280722
Publikováno v:
Journal of Medicinal Chemistry. 37:177-183
A number of N9-alkyl-substituted purines and purine ribonucleosides have been synthesized as congeners of sulfinosine and evaluated for their antileukemic activity in mice. NaH-mediated alkylation of 6-chloropurine (4) and 2-amino-6-chloropurine (5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f7f09196ead8610f8686c9724d9589
https://doi.org/10.1021/jm00027a022
https://doi.org/10.1021/jm00027a022
Autor:
Atsushi Takada, Chisa Ukawa, Tamaki Hirama, Howard B. Cottam, Roland K. Robins, Katsuhiko Nagahara, Shinji Sasaoka, Hiroko Kawano
Publikováno v:
Journal of Heterocyclic Chemistry. 31:239-243
A one-pot synthesis using 5-aminopyrazole derivatives 1 with ethoxymethylenemalononitrile (EMMN), ethyl ethoxymethylenecyanoacetate (EMCA) or diethyl ethoxymethylenemalonate (DEMM) gave pyrazolo-[1,5-a]pyrimidine compounds 2,4,8. Also, the one step r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae87bd3b3ac3c6a497744c8b993877a
https://doi.org/10.1002/jhet.5570310140
https://doi.org/10.1002/jhet.5570310140
Publikováno v:
Journal of medicinal chemistry. 10(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02e8d3e61ceb87df89e64aca710aea7
https://pubmed.ncbi.nlm.nih.gov/22185124
https://pubmed.ncbi.nlm.nih.gov/22185124
Autor:
Birendra K. Bhattacharya, Yogesh S. Sanghvi, T. Sudhakar Rao, Ganapathi R. Revankar, Arthur F. Lewis, Roland K. Robins
Publikováno v:
Journal of Heterocyclic Chemistry. 30:1341-1349
A number of N- and C-alkyl derivatives of selected guanine analogs have been synthesized as potential antiviral agents. n-Pentyl, n-hexyl and 6-hydroxyhexyl derivatives in the imidazo[1,2-α]-s-triazine, 9–11, imid-azo[1,2-α]pyrimidine, 13–17, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23881034c0ae2f95fea62304bda55ebd
https://doi.org/10.1002/jhet.5570300527
https://doi.org/10.1002/jhet.5570300527
Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines
Publikováno v:
Journal of Medicinal Chemistry. 36:3431-3436
Several simple 8-substituted 9-alkyl- and 7,8-disubstituted 9-alkylguanine derivatives were synthesized as potential antiviral agents. These were tested for antiviral protection against a lethal Semliki Forest virus (SFV) infection in mice, and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d35459fd90690e8b6c59348456bc4b7
https://doi.org/10.1021/jm00074a025
https://doi.org/10.1021/jm00074a025
Publikováno v:
ChemInform. 22
2-Amino-9-β-D-ribofuranosylpurine-2-sulfonamide (2-sulfamoyladenosine, 4), a congener of sulfonosine (3), was synthesized by four different routes. Acid catalyzed fusion of 6-chloropurine-2-sulfonyl fluoride (5) with 1,2,3,5-tetra-O-acetyl-β-D-ribo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::622d97f5eaf61745b1dcc6103e00847c
https://doi.org/10.1002/chin.199111326
https://doi.org/10.1002/chin.199111326