Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells

Autor: Paul de Vos, Zlatan Mujagic, Bart J. de Haan, Roland J. Siezen, Peter A. Bron, Marjolein Meijerink, Jerry M. Wells, Ad A. M. Masclee, Mark V. Boekschoten, Marijke M. Faas, Freddy J. Troost

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Orally ingested bacteria interact with intestinal mucosa and may impact immunity. However, insights in mechanisms involved are limited. In this randomized placebo-controlled cross-over trial, healthy human subjects were given Lactobacillus plantarum

Externí odkaz: https://doaj.org/article/8e6b70410a6b40629d6cff18c5ed8689

A Novel Quality Measure and Correction Procedure for the Annotation of Microbial Translation Initiation Sites.

Autor: Lex Overmars, Roland J Siezen, Christof Francke

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0133691 (2015)

The identification of translation initiation sites (TISs) constitutes an important aspect of sequence-based genome analysis. An erroneous TIS annotation can impair the identification of regulatory elements and N-terminal signal peptides, and also may

Externí odkaz: https://doaj.org/article/e081371bcd0e4743aee3e764ed86d069

Combining chemoinformatics with bioinformatics: in silico prediction of bacterial flavor-forming pathways by a chemical systems biology approach 'reverse pathway engineering'.

Autor: Mengjin Liu, Bruno Bienfait, Oliver Sacher, Johann Gasteiger, Roland J Siezen, Arjen Nauta, Jan M W Geurts

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84769 (2014)

The incompleteness of genome-scale metabolic models is a major bottleneck for systems biology approaches, which are based on large numbers of metabolites as identified and quantified by metabolomics. Many of the revealed secondary metabolites and/or

Externí odkaz: https://doaj.org/article/5a4162786ca7438eace1a54b81d82641

Draft genome Sequences of 11 Lactococcus lactis subsp. cremoris strains

Autor: Annereinou R. Dijkstra, Jos Boekhorst, Roland J. Siezen, Marke M. Beerthuyzen, Sacha A. F. T. van Hijum, Lennart Backus, Michiel Wels, Herwig Bachmann

Publikováno v: Genome Announcements, 5, e01739-16-e01739-16
Wels, M, Backus, L, Boekhorst, J, Dijkstra, A, Beerthuyzen, M, Siezen, R J, Bachmann, H & van Hijum, S A F T 2017, ' Draft genome Sequences of 11 Lactococcus lactis subsp. cremoris strains ', Genome Announcements, vol. 5, no. 11, e01739-16, pp. e01739-16 . https://doi.org/10.1128/genomeA.01739-16
Genome Announcements, 5, 11, pp. e01739-16-e01739-16
Genome Announcements, 5(11):e01739-16, e01739-16. American Society for Microbiology

The lactic acid bacterium Lactococcus lactis is widely used for the fermentation of dairy products. Here, we present the draft genome sequences of 11 L. lactis subsp. cremoris strains isolated from different environments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5260b19fd99eb937a5f3a0ab53cfbc16
https://research.vu.nl/en/publications/1b458336-f22a-46fb-9fc2-16b470d542ef

Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease

Autor: Na Tian, Detlef Schuppan, Roland J. Siezen, Eva J. Helmerhorst, Guoxian Wei

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G571-G580

Gluten are proline- and glutamine-rich proteins present in wheat, barley, and rye and contain the immunogenic sequences that drive celiac disease (CD). Rothia mucilaginosa, an oral microbial colonizer, can cleave these gluten epitopes. The aim was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1925cd5d2120aec5671c108d2ec18713
https://doi.org/10.1152/ajpgi.00185.2016