Výsledky vyhledávání - "Roland J. Levinsky"

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

Autor: Roland J. Levinsky, Kimberly Gilmour, Manfred Schmidt, Joanna Sinclair, John L. Smith, Abdulaziz Al Ghonaium, H. Bobby Gaspar, Marianne Antonius Jakobsen, Christine Kinnon, Kathryn L. Parsley, Doug King, Christof von Kalle, Torben Barington, Robin R. Ali, Harry N White, Gaby Brouns, Hans Ole Christensen, Adrian J. Thrasher, Steven J. Howe

Publikováno v: The Lancet. 364:2181-2187

X-linked severe combined immunodeficiency (SCID-X1) is caused by mutations in the common cytokine-receptor gamma chain (gamma(c)), resulting in disruption of development of T lymphocytes and natural-killer cells. B-lymphocyte function is also intrins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade502991b17c02958de4cd769cd7a19
https://doi.org/10.1016/s0140-6736(04)17590-9

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High-Titer Recombinant Adeno-Associated Virus Production from Replicating Amplicons and Herpes Vectors Deleted for Glycoprotein H

Autor: Robin R. Ali, M De Alwis, Roland J. Levinsky, Stephen L. Hart, Adrian J. Thrasher, S. C. Inglis, Christine Kinnon, Xiaoliu Zhang, F. W. Fitzke, Mike Boursnell

Publikováno v: Human Gene Therapy. 10:2527-2537

Production of high-titer rAAV is essential for in vivo clinical application. One limiting factor may be the failure of existing systems to replicate the packaging genome in such a way that expression of Rep and Cap proteins is coordinately amplified.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b43cf9f93e09345a92efd1cb884cf53
https://doi.org/10.1089/10430349950016861

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Lipid-Mediated Enhancement of Transfection by a Nonviral Integrin-Targeting Vector

Autor: R P Harbottle, Carolina V. Arancibia-Cárcamo, Roland J. Levinsky, Margreet A. Wolfert, Leonard W. Seymour, Robin R. Ali, Carolina Mailhos, Daniel F P Larkin, A Knight, Adrian J. Thrasher, Stephen L. Hart, Andrew J.T. George, Christine Kinnon, Nicola O’Reilly, Charles Coutelle

Publikováno v: Human Gene Therapy. 9:575-585

Nonviral vectors consisting of integrin-targeting peptide/DNA (ID) complexes have the potential for widespread application in gene therapy. The transfection efficiency of this vector, however, has been limited by endosomal degradation. We now report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ac8ede040c08cb0a97fd785f4ce680
https://doi.org/10.1089/hum.1998.9.4-575

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Mouse serum amyloid A (SAA) proteins isolated by two-dimensional electrophoresis: characterization of isotypes and the effect of separate and combined administrations of cytokines, dexamethasone and lipopolysaccharide (LPS) on serum levels and isotype distribution

Autor: Hubert B. Gaspar, T Lester, Roland J. Levinsky, Christine Kinnon

Publikováno v: Clinical and Experimental Immunology. 111:231-236

Mutations in the Bruton's tyrosine kinase (BTK) gene result in XLA. Despite the large numbers of BTK mutations reported, no correlation can be made between the clinical phenotype and the gene defects. Analysis of Btk protein expression and activity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0135fc54a38efb110ec2363235880dba
https://doi.org/10.1046/j.1365-2249.1998.00503.x

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Efficient retroviral transduction of human bone marrow progenitor and long-term culture-initiating cells: partial reconstitution of cells from patients with X-linked chronic granulomatous disease by gp91-phox expression

Autor: Roland J. Levinsky, Colin D. Porter, Christine Kinnon, Mohamed H. Parkar, Mary Collins

Publikováno v: Blood. 87:3722-3730

The primary immunodeficiencies are attractive candidates for the development of gene therapy approaches based on the transduction of hematopoietic cells. We have constructed a high-titer recombinant retrovirus for expression of gp91-phox, deficiencie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3bf211edef3658644c6813bdbd4c578
https://doi.org/10.1182/blood.v87.9.3722.bloodjournal8793722

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The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase

Autor: Ruth C. Lovering, Roland J. Levinsky, S. Hinshelwood, Christine Kinnon, Giles O. Cory, L. Maccarthy-Morrogh

Publikováno v: The Journal of Experimental Medicine

X-linked agammaglobulinemia, a B cell immunodeficiency, is caused by mutations in the Bruton's tyrosine kinase (Btk) gene. The absence of a functional Btk protein leads to a failure of B cell differentiation and antibody production. B cell receptor s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0320ab7cc5a6b898407b8e00242bd8f6
https://doi.org/10.1084/jem.182.2.611

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Trisomy X in a female member of a family with X linked severe combined immunodeficiency: implications for carrier diagnosis

Autor: M De Alwis, Roland J. Levinsky, T Lester, P A Clark, Alison Jones, Christine Kinnon, F. Katz

Publikováno v: Journal of Medical Genetics. 31:717-720

We describe a family affected by X linked severe combined immunodeficiency (SCIDX1) in which genetic prediction of carrier status was made using X chromosome inactivation studies together with limited genetic linkage analysis. Linkage studies in this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50e53c7299da4e90e4c61e0c5a772b9
https://doi.org/10.1136/jmg.31.9.717

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X-linked agammaglobulinemia - gene cloning and future prospects

Autor: Roland J. Levinsky, Steve Hinshelwood, Christine Kinnon, Ruth C. Lovering

Publikováno v: Immunology Today. 14:554-558

The btk gene has recently been identified as the causative gene in X-linked agammaglobulinemia (XLA). This has opened up many new possibilities for the treatment of this B-cell immunodeficiency. Christine Kinnon and colleagues review the high degree

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59fb2b4c716a154416a88d81b14630bd
https://doi.org/10.1016/0167-5699(93)90187-p

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Carrier determination for X-linked agammaglobulinemia using X inactivation analysis of purified B cells

Autor: Alison Jones, Christine Kinnon, Ruth C. Lovering, Sally Genet, Mahesh de Alwis, Helen Middleton-Price, Sue Malcolm, Gareth Morgan, Roland J. Levinsky, Lesley A. Alterman

Publikováno v: Journal of Immunological Methods. 166:111-116

We report the development of a relatively quick and simple method for the assessment of X inactivation status for carrier determination in families affected by X-linked agammaglobulinemia (XLA). This method utilises an immunomagnetic separation techn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a81425c6835c2b63b7929f9b221aff
https://doi.org/10.1016/0022-1759(93)90334-4

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X-linked chronic granulomatous disease: correction of NADPH oxidase defect by retrovirus-mediated expression of gp91-phox

Autor: Mary Collins, Roland J. Levinsky, Mohamed H. Parkar, Colin D. Porter, Christine Kinnon

Publikováno v: Blood. 82:2196-2202

Chronic granulomatous disease (CGD) is an inherited immunodeficiency resulting from the inability of an individual's phagocytes to produce superoxide anions because of defective NADPH oxidase. The disease may be treated by bone marrow transplantation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79abac2a94e2606d5280eb05076d35ad
https://doi.org/10.1182/blood.v82.7.2196.2196

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