Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Roland Humm"'
Autor:
Roger Schibli, Matthias Schild, Yingfang He, Linjing Mu, Claudia Keller, Uwe Grether, Luca Gobbi, Roland Humm
Publikováno v:
Nuclear Medicine and Biology. :S36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::957d945892373e59974dba38a022a5ef
https://doi.org/10.1016/s0969-8051(21)00322-x
https://doi.org/10.1016/s0969-8051(21)00322-x
Autor:
Pascale David-Pierson, David Banner, Wolfgang Wostl, Wolfgang Guba, Emmanuel Pinard, Thorsten Muser, Harald Mauser, Hans Hilpert, Thomas Johannes Woltering, Daniela Krummenacher, Holger Fischer, Alessandra Polara, Schnider Christian, Andreas Kuglstatter, Robert Narquizian, Helmut Jacobsen, Laurence Ozmen, Roland Humm, Alessandra Bergadano, Remo Hochstrasser, Mark Rogers-Evans, Alexander V. Mayweg
Publikováno v:
Journal of Medicinal Chemistry. 56:3980-3995
An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pKa and thereby dramatically change the pharmacological profile of this class of BACE1 inhibitors. The CF3 substituted oxazine 89, a potent and highly brain pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb83a85e859669cfa4b43b0b259900cf
https://doi.org/10.1021/jm400225m
https://doi.org/10.1021/jm400225m
Autor:
Hans Hilpert, Holger Kuehne, Martine Stihle, David Banner, Lilli Anselm, Guido Hartmann, Roland Humm, Beat Wirz, Sabine Gruener, Hans Iding, Andreas Kuglstatter, Harald Mauser, Wolfgang Haap, Ralf Thoma, Joerg Benz, Bernard Gsell, Ruben Alvarez Sanchez
Publikováno v:
Journal of medicinal chemistry. 56(23)
Starting from the weakly active dual CatS/K inhibitor 5, structure-based design supported by X-ray analysis led to the discovery of the potent and selective (>50 000-fold vs CatK) cyclopentane derivative 22 by exploiting specific ligand–receptor in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21c44403b1427d5e990f879a96d8f06
https://pubmed.ncbi.nlm.nih.gov/24224654
https://pubmed.ncbi.nlm.nih.gov/24224654
Autor:
Roland Humm, Markus Meyer, Hans Hilpert, Joerg Benz, Maerki Hans P, Uwe Grether, Bernd Kuhn, Peter Mohr, Alfred Binggeli
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(15)
In the quest for novel PPARalpha/gamma co-agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we have used a structure-based design approach to identify propionic acids with a 1,5-disubstituted indole scaffold as potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2445d2392de7756ad82ff498a8b226e3
https://pubmed.ncbi.nlm.nih.gov/16737814
https://pubmed.ncbi.nlm.nih.gov/16737814