Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Roland Houben"'
Autor:
Roland Houben
Publikováno v:
Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-4 (2023)
Abstract Background Severe acute respiratory syndrome coronavirus 2 is a virus affecting different organs and causing a wide variety and severity of symptoms. Headache as well as loss of smell and taste are the most frequently reported neurological m
Externí odkaz:
https://doaj.org/article/a60452bb96404521ba3eda4e5edef6e6
Autor:
Roland Houben, Pamela Alimova, Bhavishya Sarma, Sonja Hesbacher, Carolin Schulte, Eva-Maria Sarosi, Christian Adam, Thibault Kervarrec, David Schrama
Publikováno v:
Cancers, Vol 15, Iss 9, p 2542 (2023)
Merkel cell carcinoma (MCC) is frequently caused by the Merkel cell polyomavirus (MCPyV), and MCPyV-positive tumor cells depend on expression of the virus-encoded T antigens (TA). Here, we identify 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phth
Externí odkaz:
https://doaj.org/article/301e99a9353f4e3a8d748fb88c8cc2d4
Publikováno v:
Cancers, Vol 15, Iss 2, p 444 (2023)
The best characterized polyomavirus family member, i.e., simian virus 40 (SV40), can cause different tumors in hamsters and can transform murine and human cells in vitro. Hence, the SV40 contamination of millions of polio vaccine doses administered f
Externí odkaz:
https://doaj.org/article/d97f0888c4a14ccbababcc50fb789daf
Autor:
Giada Dogliotti, Lars Kullmann, Pratibha Dhumale, Christian Thiele, Olga Panichkina, Gudrun Mendl, Roland Houben, Sebastian Haferkamp, Andreas W. Püschel, Michael P. Krahn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/b7a3c17290984114b9d8ef7bd4d66ae9
Autor:
Alexander Thiem, Sonja Hesbacher, Hermann Kneitz, Teresa di Primio, Markus V. Heppt, Heike M. Hermanns, Matthias Goebeler, Svenja Meierjohann, Roland Houben, David Schrama
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-15 (2019)
Abstract Background Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associated with better cl
Externí odkaz:
https://doaj.org/article/f763bb8e779141d8a8d6767b053ede39
Autor:
Marion Wobser, Alexandra Weber, Amelie Glunz, Saskia Tauch, Kristina Seitz, Tobias Butelmann, Sonja Hesbacher, Matthias Goebeler, René Bartz, Hella Kohlhof, David Schrama, Roland Houben
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach. Here, we compared the mode of action of romidepsin (FK228), an establi
Externí odkaz:
https://doaj.org/article/a44783db4f2242dd9008d5dd78ff5fa5
Autor:
Clara Esnault, David Schrama, Roland Houben, Serge Guyétant, Audrey Desgranges, Camille Martin, Patricia Berthon, Marie-Claude Viaud-Massuard, Antoine Touzé, Thibault Kervarrec, Mahtab Samimi
Publikováno v:
Cancers, Vol 14, Iss 3, p 778 (2022)
Antibody–drug conjugates (ADCs) are an emerging class of therapeutics, with twelve FDA- and EMA-approved drugs for hematological and solid cancers. Such drugs consist in a monoclonal antibody linked to a cytotoxic agent, allowing a specific cytotox
Externí odkaz:
https://doaj.org/article/898f70c728cb40168fde240ad075d38f
Autor:
Marion Wobser, Sabine Roth, Silke Appenzeller, Roland Houben, David Schrama, Matthias Goebeler, Eva Geissinger, Andreas Rosenwald, Katja Maurus
Publikováno v:
Cancers, Vol 13, Iss 21, p 5512 (2021)
Introduction: Large-cell transformation (LCT) of mycosis fungoides (MF) has been associated with a higher risk of relapse and progression and, consequently, restricted prognosis. Its molecular pathogenesis has not been elucidated yet. Materials and M
Externí odkaz:
https://doaj.org/article/15afe10b47fb451e98654f4fce88d87d
Autor:
Giada Dogliotti, Lars Kullmann, Pratibha Dhumale, Christian Thiele, Olga Panichkina, Gudrun Mendl, Roland Houben, Sebastian Haferkamp, Andreas W. Püschel, Michael P. Krahn
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
LKB1 regulates various cellular processes such as cell proliferation, energy homeostasis and cell polarity and is frequently downregulated in various tumours. Here the authors show that LKB1 activation requires direct binding to phospholipids and sho
Externí odkaz:
https://doaj.org/article/93f85e172ac9493897b09df8f487de33
Autor:
Thibault Kervarrec, Mahtab Samimi, Serge Guyétant, Bhavishya Sarma, Jérémy Chéret, Emmanuelle Blanchard, Patricia Berthon, David Schrama, Roland Houben, Antoine Touzé
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al. identified Merkel cell polyomavirus (MCPyV) integrati
Externí odkaz:
https://doaj.org/article/87cd8456e5ac4dc8901879c3056672be