Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Roland Heyny-von Haußen"'
Autor:
Christine Kuhmann, Andreas Dietz, Klaus W. Delank, Tsun Leung Chan, Burkhard M. Lippert, Manfred H. Bohrer, Justo Lorenzo Bermejo, Odilia Popanda, Olga Bogatyrova, Karl Hörmann, Heiko Becher, Yassen Assenov, Christopher C. Oakes, Simone Kaucher, Petra Boukamp, Christoph Weigel, Volker Winkler, Alexander Marx, Felix Lasitschka, Roland Heyny-von Haußen, Suet Yi Leung, Gerhard Dyckhoff, Christoph Plass, Peter Schmezer, Gerald Baier, Christel Herold-Mende, Jittiporn Chaisaingmongkol, Irene Santi, Heribert Ramroth
Publikováno v:
Clinical Epigenetics
Background Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8deb7464e4a82016813f75189f9acf4d
https://doi.org/10.1186/s13148-019-0666-5
https://doi.org/10.1186/s13148-019-0666-5
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains
Autor:
Gerhard Mall, Christian Schön, Roland Heyny-von Haußen, Christian Czech, Jana Hölzer, Thomas Kramer, Jochen Herms, Boris Schmidt, Valerie Goetschy-Meyer, Ingrid Hilger, Jiamin Gu, Upendra Rao Anumala, Fabio Lo Monte
Publikováno v:
Bioorganic & medicinal chemistry 21(17), 5139-5144 (2013). doi:10.1016/j.bmc.2013.06.039
There is a high demand for the development of an imaging agent for neurofibrillary tangles (NFTs) detection in Alzheimer's diagnosis. In the present study, a series of rhodanine-3-acetic acids was synthesized and evaluated for fluorescence imaging of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5770513ffb9ee75d9347104ebeea3158
https://pubmed.ncbi.nlm.nih.gov/23859773
https://pubmed.ncbi.nlm.nih.gov/23859773
Autor:
Upendra Rao Anumala, Roland Heyny-von Haußen, Ingrid Hilger, Valerie Goetschy-Meyer, Christian Czech, Jiamin Gu, Jana Hölzer, Boris Schmidt, Gerhard Mall
Publikováno v:
ChemMedChem. 8(6)
Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post-mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d7f06508ac521b4fb6fa7fd330e8e0
https://pubmed.ncbi.nlm.nih.gov/23592568
https://pubmed.ncbi.nlm.nih.gov/23592568
Autor:
Christoph Scholz, Roland Heyny-von Haußen, Alexander Boländer, Christian Czech, Gerhard Mall, Daniel Kieser, Boris Schmidt, Valérie Goetschy
Publikováno v:
Neuro-degenerative diseases. 13(4)
Background: Alzheimer's disease is characterized by two notorious protein aggregates in the brain: extracellular senile plaques mainly consisting of amyloid-β peptides and tau-protein-derived intracellular paired helical filaments. The diagnosis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6dc24262e264f6a1fdb2c1fdc0eb0e
https://pubmed.ncbi.nlm.nih.gov/24080522
https://pubmed.ncbi.nlm.nih.gov/24080522
Autor:
Christian Schön, Valérie Goetschy, Ingrid Hilger, Tobias Bittner, Daniel Kieser, Silvia Bauer, Boris Schmidt, Henner Knust, Steffen Burgold, Roland Heyny-von Haußen, Jochen Herms, Robert Berger, Gerhard Mall, Constantin Voss, Christian Czech, Alexander Boländer, Jana Hölzer
Publikováno v:
Journal of medicinal chemistry 55(21), 9170-9180 (2012). doi:10.1021/jm300653b
The in vivo diagnosis of Alzheimer's disease (AD) is of high socioeconomic interest and remains a demanding field of research. The biopathological hallmarks of the disease are extracellular plaques consisting of aggregated β-amyloid peptides (Aβ) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb250c85f195c6a84fea52852040ac
https://pubmed.ncbi.nlm.nih.gov/22913544
https://pubmed.ncbi.nlm.nih.gov/22913544
Autor:
Ingrid Hilger, Thomas Kramer, Jiamin Gu, Valerie Goetschy-Meyer, Fabio Lo Monte, Gerhard Mall, Upendra Rao Anumala, Jana Hölzer, Boris Schmidt, Roland Heyny-von Haußen, Christian Czech
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
We evaluated 2-styrylindolium derivatives (6-11) as novel and selective probes for neurofibrillary tangles (NFTs) on brain sections of AD patients. The staining experiments indicated that these compounds may bind selectively to NFTs in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc6daaee6739f3827bdb8c6462c13d8
https://pubmed.ncbi.nlm.nih.gov/23127889
https://pubmed.ncbi.nlm.nih.gov/23127889