Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Roland H Wenger"'
Autor:
Anna Keppner, Miguel Correia, Sara Santambrogio, Teng Wei Koay, Darko Maric, Carina Osterhof, Denise V Winter, Angèle Clerc, Michael Stumpe, Frédéric Chalmel, Sylvia Dewilde, Alex Odermatt, Dieter Kressler, Thomas Hankeln, Roland H Wenger, David Hoogewijs
Publikováno v:
eLife, Vol 11 (2022)
Spermatogenesis is a highly specialized differentiation process driven by a dynamic gene expression program and ending with the production of mature spermatozoa. Whereas hundreds of genes are known to be essential for male germline proliferation and
Externí odkaz:
https://doaj.org/article/e692440467a1446e9f1f94e8b46fc3c1
Autor:
Carsten C Scholz, Javier Rodriguez, Christina Pickel, Stephen Burr, Jacqueline-Alba Fabrizio, Karen A Nolan, Patrick Spielmann, Miguel A S Cavadas, Bianca Crifo, Doug N Halligan, James A Nathan, Daniel J Peet, Roland H Wenger, Alex Von Kriegsheim, Eoin P Cummins, Cormac T Taylor
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002347 (2016)
The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a g
Externí odkaz:
https://doaj.org/article/195eb6b4e4534a8d981fea77cbdb36dd
Autor:
Philippe A Hasgall, David Hoogewijs, Marius B Faza, Vikram G Panse, Roland H Wenger, Gieri Camenisch
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22107 (2011)
The hypoxia-inducible transcription factor (HIF) is a key component of the cellular adaptation mechanisms to hypoxic conditions. HIFα subunits are degraded by prolyl-4-hydroxylase domain (PHD) enzyme-dependent prolyl-4-hydroxylation of LxxLAP motifs
Externí odkaz:
https://doaj.org/article/556484b79578488781c6b64f2eb71a06
Autor:
Anu Sharma, Beata Bode, Roland H Wenger, Kuno Lehmann, Alessandro A Sartori, Holger Moch, Alexander Knuth, Lotta von Boehmer, Maries van den Broek
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28217 (2011)
BACKGROUND: γ-radiation is an effective treatment for cancer. There is evidence that radiotherapy supports tumor-specific immunity. It was described that irradiation induces de novo protein synthesis and enhances antigen presentation, we therefore i
Externí odkaz:
https://doaj.org/article/e60bca425d204e78b70e27d03d17968b
Autor:
Willy Kuo, Diego Rossinelli, Georg Schulz, Roland H. Wenger, Simone Hieber, Bert Müller, Vartan Kurtcuoglu
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-10 (2023)
Abstract The performance of machine learning algorithms, when used for segmenting 3D biomedical images, does not reach the level expected based on results achieved with 2D photos. This may be explained by the comparative lack of high-volume, high-qua
Externí odkaz:
https://doaj.org/article/a774222749ca466d827280cc16955942
Autor:
Merve Kayhan, Judith Vouillamoz, Daymé Gonzalez Rodriguez, Milica Bugarski, Yasutaka Mitamura, Julia Gschwend, Christoph Schneider, Andrew Hall, David Legouis, Cezmi A. Akdis, Leary Peter, Hubert Rehrauer, Leslie Gewin, Roland H. Wenger, Stellor Nlandu Khodo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Excessive TGF-β signaling and mitochondrial dysfunction fuel chronic kidney disease (CKD) progression. However, inhibiting TGF-β failed to impede CKD in humans. The proximal tubule (PT), the most vulnerable renal segment, is packed with gi
Externí odkaz:
https://doaj.org/article/e2750f6de0d049b9a4d018aabbf94898
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-26 (2021)
Abstract Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical outcome. The significance of hypoxia in the development of resistance to radiotherapy has been recognized for decades and the search for hypoxia-targ
Externí odkaz:
https://doaj.org/article/cc4bc911314f4f43bb50c1a3e7cc36f6
Autor:
Simona Simmen, Max Maane, Sarah Rogler, Katherina Baebler, Silvia Lang, Jesus Cosin-Roger, Kirstin Atrott, Isabelle Frey-Wagner, Partick Spielmann, Roland H. Wenger, Bruce Weder, Jonas Zeitz, Stephan R. Vavricka, Gerhard Rogler, Cheryl de Vallière, Martin Hausmann, Pedro A. Ruiz
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-14 (2021)
Introduction: Intestinal fibrosis, characterized by excessive deposition of extracellular matrix proteins, is a common and severe clinical complication of inflammatory bowel disease (IBD). However, the mechanisms underlying fibrosis remain elusive, a
Externí odkaz:
https://doaj.org/article/d64d1537f9a94c2ab49ba22fe8d8e8b2
Autor:
Jesus F. Glaus Garzon, Chiara Pastrello, Igor Jurisica, Michael O. Hottiger, Roland H. Wenger, Lubor Borsig
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 745-758 (2020)
Hypoxia and inflammation are key factors for colorectal cancer tumorigenesis. The colonic epithelium belongs to the tissues with the lowest partial pressure of oxygen in the body, and chronic inflammation is associated with an increased chance to dev
Externí odkaz:
https://doaj.org/article/71e1ac146d6c4409bb0448ce83cf2137
Autor:
Bjørt K. Kragesteen, Amir Giladi, Eyal David, Shahar Halevi, Laufey Geirsdóttir, Olga M. Lempke, Baoguo Li, Andreas M. Bapst, Ken Xie, Yonatan Katzenelenbogen, Sophie L. Dahl, Fadi Sheban, Anna Gurevich-Shapiro, Mor Zada, Truong San Phan, Roberto Avellino, Shuang-Yin Wang, Oren Barboy, Shir Shlomi-Loubaton, Sandra Winning, Philipp P. Markwerth, Snir Dekalo, Hadas Keren-Shaul, Merav Kedmi, Martin Sikora, Joachim Fandrey, Thorfinn S. Korneliussen, Josef T. Prchal, Barak Rosenzweig, Vladimir Yutkin, Fernando Racimo, Eske Willerslev, Chamutal Gur, Roland H. Wenger, Ido Amit
Publikováno v:
Nature Medicine. 29:1191-1200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bac8fe6a9d1c6d74230c96084677c2
https://doi.org/10.1038/s41591-023-02314-7
https://doi.org/10.1038/s41591-023-02314-7