Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ.

Autor: Yassmine Chebaro, Serena Sirigu, Ismail Amal, Régis Lutzing, Roland H Stote, Cécile Rochette-Egly, Natacha Rochel, Annick Dejaegere

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0171043 (2017)

Retinoic acid (RA) plays key roles in cell differentiation and growth arrest through nuclear retinoic acid receptors (RARs), which are ligand-dependent transcription factors. While the main trigger of RAR activation is the binding of RA, phosphorylat

Externí odkaz: https://doaj.org/article/b60cf716b04d4b34a088cf4de395e4a3

Phosphorylation of the retinoic acid receptor alpha induces a mechanical allosteric regulation and changes in internal dynamics.

Autor: Yassmine Chebaro, Ismail Amal, Natacha Rochel, Cécile Rochette-Egly, Roland H Stote, Annick Dejaegere

Publikováno v: PLoS Computational Biology, Vol 9, Iss 4, p e1003012 (2013)

Nuclear receptor proteins constitute a superfamily of proteins that function as ligand dependent transcription factors. They are implicated in the transcriptional cascades underlying many physiological phenomena, such as embryogenesis, cell growth an

Externí odkaz: https://doaj.org/article/47e46ec66d354c34b6bb4118eeab95d1

1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action against Parkinson’s Disease

Autor: Joseph C. J. Bergin, Kean Kan Tan, Anya K. Nelson, Cristina-Andreea Amarandei, Véronique Hubscher-Bruder, Jérémy Brandel, Varvara Voinarovska, Annick Dejaegere, Roland H. Stote, David Tétard

Publikováno v: Molecules, Vol 27, Iss 9, p 2816 (2022)

Two analogues of tolcapone where the nitrocatechol group has been replaced by a 1-hydroxy-2(1H)-pyridinone have been designed and synthesised. These compounds are expected to have a dual mode of action both beneficial against Parkinson’s disease: t

Externí odkaz: https://doaj.org/article/a3e1dccf1d9f4361af52330af6009138

Peptide-Protein Binding Investigated by Far-IR Spectroscopy and Molecular Dynamics Simulations

Autor: yoann cote, Juan D. Ramirez, Petra Hellwig, Yves Nominé, Roland H. Stote

Publikováno v: Biophysical Journal
Biophysical Journal, Biophysical Society, 2017, 112 (12), pp.2575-2588. ⟨10.1016/j.bpj.2017.05.018⟩
Biophysical Journal, 2017, 112 (12), pp.2575-2588. ⟨10.1016/j.bpj.2017.05.018⟩

PMC5479146; Molecular dynamics (MD) simulations and far-infrared (far-IR) spectroscopy were combined to study peptide binding by the second PDZ domain (PDZ1) of MAGI1, which has been identified as an important target for the Human Papilloma Virus. PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c1129f69f92388b4a7b63633f62b64
https://doi.org/10.1016/j.bpj.2017.05.018

Allostery in Its Many Disguises: From Theory to Applications

Autor: Yassmine Chebaro, Annick Dejaegere, Ruth Nussinov, Rebecca C. Wade, Simone Orioli, Jocelyne Vreede, Riccardo Ravasio, Paraskevi Gkeka, Jing Li, Gerhard Stock, Chung-Jung Tsai, Ivet Bahar, Emanuele Paci, Pietro Faccioli, Joanna Panecka-Hofman, John Karanicolas, Peter G. Bolhuis, Jean-Pierre Changeux, Shoshana J. Wodak, Masha Y. Niv, Antonella Di Pizio, Giulia Palermo, Roland H. Stote, Tom McLeish, Matthieu Wyart, Carolina Brito, Peter Hamm, J. Andrew McCammon, Vincent J. Hilser, Amnon Horovitz, Jerome Eberhardt, Ivan Rivalta, Nikolay V. Dokholyan, Igor N. Berezovsky, Marco Cecchini, Le Yan, Hyunbum Jang, Dima Kozakov, Dzmitry Padhorny

Publikováno v: Structure (London, England : 1993), vol 27, iss 4
Structure
Structure, Elsevier (Cell Press), 2019, 27 (4), pp.566-578. ⟨10.1016/j.str.2019.01.003⟩
Structure, 27(4), 566-578. Cell Press
Wodak, Shoshana J; Paci, Emanuele; Dokholyan, Nikolay V; Berezovsky, Igor N; Horovitz, Amnon; Li, Jing; et al.(2019). Allostery in Its Many Disguises: From Theory to Applications.. Structure (London, England : 1993), 27(4), 566-578. doi: 10.1016/j.str.2019.01.003. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/1n3019zg

Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, and metabolism. Allostery is rooted in the fundamental physical properties of macromo-lecular systems, but its underl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b910311b99a61bf324b685738c2e2e4
https://escholarship.org/uc/item/1n3019zg