Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Roland H Stimson"'
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0297601 (2024)
ObjectiveImpaired awareness of hypoglycaemia (IAH) is a risk factor for severe hypoglycaemia (SH) in type 1 diabetes (T1D). Much of the IAH prevalence data comes from older studies where participants did not have the benefit of the latest insulins an
Externí odkaz:
https://doaj.org/article/65df4bbee8184d4e8948cd7901268385
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
Autor:
Karla J Suchacki, Benjamin J Thomas, Yoshiko M Ikushima, Kuan-Chan Chen, Claire Fyfe, Adriana AS Tavares, Richard J Sulston, Andrea Lovdel, Holly J Woodward, Xuan Han, Domenico Mattiucci, Eleanor J Brain, Carlos J Alcaide-Corral, Hiroshi Kobayashi, Gillian A Gray, Phillip D Whitfield, Roland H Stimson, Nicholas M Morton, Alexandra M Johnstone, William P Cawthorn
Publikováno v:
eLife, Vol 12 (2023)
Caloric restriction (CR) reduces the risk of age-related diseases in numerous species, including humans. CR’s metabolic effects, including decreased adiposity and improved insulin sensitivity, are important for its broader health benefits; however,
Externí odkaz:
https://doaj.org/article/b9038b3cadf8461faa31dbc4889698f6
Autor:
Dimitrios Chantzichristos, Per-Arne Svensson, Terence Garner, Camilla AM Glad, Brian R Walker, Ragnhildur Bergthorsdottir, Oskar Ragnarsson, Penelope Trimpou, Roland H Stimson, Stina W Borresen, Ulla Feldt-Rasmussen, Per-Anders Jansson, Stanko Skrtic, Adam Stevens, Gudmundur Johannsson
Publikováno v:
eLife, Vol 10 (2021)
Background: Glucocorticoids are among the most commonly prescribed drugs, but there is no biomarker that can quantify their action. The aim of the study was to identify and validate circulating biomarkers of glucocorticoid action. Methods: In a rando
Externí odkaz:
https://doaj.org/article/2fd4e8ec41fc4f27b347cd69da834ac2
Autor:
Roland H Stimson, Anna R Dover, Fraser W Gibb, Muhammad Al-Dalla Ali, Shareen Forbes, Roxanne Annoh, Karen Madill
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 2 (2020)
Introduction Intensification of therapy has been associated with early worsening of retinopathy prior to subsequent risk reduction. We sought to assess whether glycated hemoglobin (HbA1c) reduction, following flash monitoring, was associated with ear
Externí odkaz:
https://doaj.org/article/baeca41995f040bebf1d5e904857f792
Autor:
Roland H Stimson, Gerald E Lobley, Ioanna Maraki, Nicholas M Morton, Ruth Andrew, Brian R Walker
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8779 (2010)
Tissue glucocorticoid levels in the liver and adipose tissue are regulated by regeneration of inactive glucocorticoid by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and inactivation by 5alpha- and 5beta-reductases. A low carbohydrate die
Externí odkaz:
https://doaj.org/article/13819fc7aa984e80b5be14a35c143f75
Autor:
Kerri Devine, Elisa Villalobos, Catriona J. Kyle, Ruth Andrew, Rebecca M. Reynolds, Roland H. Stimson, Mark Nixon, Brian R. Walker
Publikováno v:
Devine, K, Villalobos, E, Kyle, C, Andrew, R, Reynolds, R M, Stimson, R H, Nixon, M & Walker, B R 2022, ' The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action ', Nature reviews endocrinology . https://doi.org/10.1038/s41574-022-00745-9
Responses to hormones that act through nuclear receptors are controlled by modulating hormone concentrations not only in the circulation but also within target tissues. The role of enzymes that amplify or reduce local hormone concentrations has becom
Autor:
Roland H. Stimson, Anna R. Dover, Mark W. J. Strachan, Rohana J. Wright, Shareen Forbes, Fraser W. Gibb
Publikováno v:
Stimson, R H, Dover, A R, Strachan, M W J, Wright, R J, Forbes, S & Gibb, F W 2023, ' Changes in continuous glucose monitoring metrics and predictors of improvement 12 months after conversion from Freestyle Libre to Freestyle Libre 2 ', Diabetic Medicine . https://doi.org/10.1111/dme.15130
AimsWe sought to assess whether conversion from Freestyle Libre to Freestyle Libre 2 (with low and high glucose alert functions) was associated with improved glucose metrics. Research Design and methodsA prospective observational study to assess chan
Autor:
Yoshiko M Ikushima, Benjamin J Thomas, Karla J Suchacki, Kuan-Chan Chen, Claire Fyfe, Adriana AS Tavares, Richard J Sulston, Andrea Lovdel, Holly J Woodward, Xuan Han, Domenico Mattiucci, Eleanor J Brain, Carlos J Alcaide-Corral, Hiroshi Kobayashi, Gillian A Gray, Phillip D Whitfield, Roland H Stimson, Nicholas M Morton, Alexandra M Johnstone, William P Cawthorn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a068d96ee897a94f3927665eb5eb02d5
https://doi.org/10.7554/elife.88080.sa2
https://doi.org/10.7554/elife.88080.sa2
Autor:
Nantia Othonos, Riccardo Pofi, Anastasia Arvaniti, Sarah White, Ilaria Bonaventura, Nikolaos Nikolaou, Ahmad Moolla, Thomas Marjot, Roland H. Stimson, André P. van Beek, Martijn van Faassen, Andrea M. Isidori, Elizabeth Bateman, Ross Sadler, Fredrik Karpe, Paul M. Stewart, Craig Webster, Joanne Duffy, Richard Eastell, Fatma Gossiel, Thomas Cornfield, Leanne Hodson, K. Jane Escott, Andrew Whittaker, Ufuk Kirik, Ruth L. Coleman, Charles A. B. Scott, Joanne E. Milton, Olorunsola Agbaje, Rury R. Holman, Jeremy W. Tomlinson
Publikováno v:
Othonos, N, Pofi, R, Arvaniti, A, White, S, Bonaventura, I, Nikolaou, N, Moolla, A, Marjot, T, Stimson, R H, Van beek, A P, Van faassen, M, Isidori, A M, Bateman, E, Sadler, R, Karpe, F, Stewart, P M, Webster, C, Duffy, J, Eastell, R, Gossiel, F, Cornfield, T, Hodson, L, Jane escott, K, Whittaker, A, Kirik, U, Coleman, R L, Scott, C A B, Milton, J E, Agbaje, O, Holman, R R & Tomlinson, J W 2023, ' 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial ', Nature Communications, vol. 14, no. 1 . https://doi.org/10.1038/s41467-023-36541-w
Nature Communications, 14(1):1025. Nature Publishing Group
Nature Communications, 14(1):1025. Nature Publishing Group
Glucocorticoids prescribed to limit inflammation, have significant adverseeffects. As 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regeneratesactive glucocorticoid, we investigated whether 11β-HSD1 inhibition withAZD4017 could mitigate adver
Autor:
Anna R. Dover, Stuart A. Ritchie, Rohana J. Wright, Emily M. McMurray, Mark W. J. Strachan, Roland H. Stimson, Shareen Forbes, Fraser W. Gibb
Publikováno v:
Dover, A R, Ritchie, S A, Wright, R J, Mcmurray, E M, Strachan, M W J, Stimson, R H, Forbes, S & Gibb, F W 2023, ' Interest in hybrid closed loop is high across the socioeconomic spectrum despite current inequalities in provision in a large UK diabetes centre ', Diabetic Medicine . https://doi.org/10.1111/dme.15058