Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Roland G Huber"'
Autor:
Wei-Xin Chin, Hao Yuin Kong, Isabelle Xin Yu Zhu, Zi Yun Teo, Regina Faruk, Regina Ching Hua Lee, Si Xian Ho, Zhen Qin Aw, Bowen Yi, Xin Jun Hou, Antson Kiat Yee Tan, Thinesshwary Yogarajah, Roland G Huber, Yu Cai, Yue Wan, Justin Jang Hann Chu
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011753 (2023)
Virus genome recoding is an attenuation method that confers genetically stable attenuation by rewriting a virus genome with numerous silent mutations. Prior flavivirus genome recoding attempts utilised codon deoptimisation approaches. However, these
Externí odkaz:
https://doaj.org/article/6c7e5f7d18a143fe966098392d649a02
Autor:
Guntur Fibriansah, Elisa X Y Lim, Jan K Marzinek, Thiam-Seng Ng, Joanne L Tan, Roland G Huber, Xin-Ni Lim, Valerie S Y Chew, Victor A Kostyuchenko, Jian Shi, Ganesh S Anand, Peter J Bond, James E Crowe, Shee-Mei Lok
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009331 (2021)
Different strains within a dengue serotype (DENV1-4) can have smooth, or "bumpy" surface morphologies with different antigenic characteristics at average body temperature (37°C). We determined the neutralizing properties of a serotype cross-reactive
Externí odkaz:
https://doaj.org/article/57de8411288847e09ca950df5135c753
Autor:
Jakob Fleischmann, Andreas Feichtner, Louis DeFalco, Valentina Kugler, Selina Schwaighofer, Roland G Huber, Eduard Stefan
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 518 (2021)
Mutations at different stages of the mitogen-activated protein kinase (MAPK) signaling pathway lead to aberrant activation of the involved protein kinase entities. These oncogenic modifications alter signal propagation which converge on the gatekeepe
Externí odkaz:
https://doaj.org/article/6411160c8b174af68957ffdf8eb8a5b7
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185928 (2017)
An improved knowledge of protein-protein interactions is essential for better understanding of metabolic and signaling networks, and cellular function. Progress tends to be based on structure determination and predictions using known structures, alon
Externí odkaz:
https://doaj.org/article/3d614f4708f94dacbf8ad91b0eaf47c8
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156963 (2016)
The bacterial cell envelope is composed of a mixture of different lipids and proteins, making it an inherently complex organelle. The interactions between integral membrane proteins and lipids are crucial for their respective spatial localization wit
Externí odkaz:
https://doaj.org/article/4cfdf16ae40b4305a5cf9c66318322d2
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 10, p e1004560 (2015)
ZAP-70 (Zeta-chain-associated protein kinase 70) is a tyrosine kinase that interacts directly with the activated T-cell receptor to transduce downstream signals, and is hence a major player in the regulation of the adaptive immune response. Dysfuncti
Externí odkaz:
https://doaj.org/article/716818c053a9484e9febaa8af1d5a4e8
Autor:
Julian E Fuchs, Roland G Huber, Birgit J Waldner, Ursula Kahler, Susanne von Grafenstein, Christian Kramer, Klaus R Liedl
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140713 (2015)
Biomolecular recognition is crucial in cellular signal transduction. Signaling is mediated through molecular interactions at protein-protein interfaces. Still, specificity and promiscuity of protein-protein interfaces cannot be explained using simpli
Externí odkaz:
https://doaj.org/article/d946510052db4ce7a8c784438ac6595c
Autor:
Michael Schauperl, Julian E Fuchs, Birgit J Waldner, Roland G Huber, Christian Kramer, Klaus R Liedl
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142658 (2015)
Calculation of cleavage entropies allows to quantify, map and compare protease substrate specificity by an information entropy based approach. The metric intrinsically depends on the number of experimentally determined substrates (data points). Thus
Externí odkaz:
https://doaj.org/article/02d0dfd1e4e54a54b322f7916d1d7710
Autor:
Julian E Fuchs, Susanne von Grafenstein, Roland G Huber, Michael A Margreiter, Gudrun M Spitzer, Hannes G Wallnoefer, Klaus R Liedl
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 4, p e1003007 (2013)
A purely information theory-guided approach to quantitatively characterize protease specificity is established. We calculate an entropy value for each protease subpocket based on sequences of cleaved substrates extracted from the MEROPS database. We
Externí odkaz:
https://doaj.org/article/12762a534f704b2c91b9811464d758a5
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 11, p e1003353 (2013)
Sequence logos are frequently used to illustrate substrate preferences and specificity of proteases. Here, we employed the compiled substrates of the MEROPS database to introduce a novel metric for comparison of protease substrate preferences. The co
Externí odkaz:
https://doaj.org/article/0c61c0e7a9f04c15a3da1ed5cdcf1f7d