Zobrazeno 1 - 10
of 2 578
pro vyhledávání: '"Roland F"'
Autor:
Ting Xie, Adi Danieli-Mackay, Mariachiara Buccarelli, Mariano Barbieri, Ioanna Papadionysiou, Q. Giorgio D’Alessandris, Claudia Robens, Nadine Übelmesser, Omkar Suhas Vinchure, Liverana Lauretti, Giorgio Fotia, Roland F. Schwarz, Xiaotao Wang, Lucia Ricci-Vitiani, Jay Gopalakrishnan, Roberto Pallini, Argyris Papantonis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Glioblastoma multiforme (GBM) encompasses brain malignancies marked by phenotypic and transcriptional heterogeneity thought to render these tumors aggressive, resistant to therapy, and inevitably recurrent. However, little is known about how
Externí odkaz:
https://doaj.org/article/b9a9957f48204cb99490c2d04c1f3281
Autor:
Roland F. J. Popp, Julia Ottersbach, Thomas C. Wetter, Sebastian Schüler, Siegfried Rothe, Daniel Betz, Siegmund Staggl, Markus Canazei
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Drowsiness while driving negatively impacts road safety, especially in truck drivers. The present study investigated the feasibility and alerting effects of a daylight-supplementing in-truck lighting system (DS) providing short-wavelength en
Externí odkaz:
https://doaj.org/article/750994a1cfb54078878ce3a1a3638c17
Autor:
Maria Stella de Biase, Florian Massip, Tzu-Ting Wei, Federico M. Giorgi, Rory Stark, Amanda Stone, Amy Gladwell, Martin O’Reilly, Daniel Schütte, Ines de Santiago, Kerstin B. Meyer, Florian Markowetz, Bruce A. J. Ponder, Robert C. Rintoul, Roland F. Schwarz
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Lung cancer is the leading cause of cancer-related death in the world. In contrast to many other cancers, a direct connection to modifiable lifestyle risk in the form of tobacco smoke has long been established. More than 50% of al
Externí odkaz:
https://doaj.org/article/1477c061531644cca19787d9aa30b28b
Autor:
Maja C. Stöber, Rocío Chamorro González, Lotte Brückner, Thomas Conrad, Nadine Wittstruck, Annabell Szymansky, Angelika Eggert, Johannes H. Schulte, Richard P. Koche, Anton G. Henssen, Roland F. Schwarz, Kerstin Haase
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114711- (2024)
Summary: Neuroblastoma exhibits significant inter- and intra-tumor genetic heterogeneity and varying clinical outcomes. Extrachromosomal DNAs (ecDNAs) may drive this heterogeneity by independently segregating during cell division, leading to rapid on
Externí odkaz:
https://doaj.org/article/ab3a75bbde6043eaa8410044fc79d0e5
Autor:
Yevgeniy Plavskin, Maria Stella de Biase, Naomi Ziv, Libuše Janská, Yuan O Zhu, David W Hall, Roland F Schwarz, Daniel Tranchina, Mark L Siegal
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002698 (2024)
The fitness effects of new mutations determine key properties of evolutionary processes. Beneficial mutations drive evolution, yet selection is also shaped by the frequency of small-effect deleterious mutations, whose combined effect can burden other
Externí odkaz:
https://doaj.org/article/5cb40ad857414c808f0a543612444351
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Distributed healthcare settings such as district hospitals, primary care, and public health facilities are becoming the real-life settings for workplace-based learning required to educate the future healthcare workforce. Therefore
Externí odkaz:
https://doaj.org/article/3cb9c063fba148568d8ffb2bf508fb56
Autor:
Carmen A. Moes, C. Tji Gan, Leonie H. Venema, Roland F. Hoffmann, Barbro N. Melgert, Huib A. M. Kerstjens, Peter Olinga, Mitchel J. R. Ruigrok
Publikováno v:
Transplantology, Vol 4, Iss 4, Pp 185-196 (2023)
Background: Donor lungs are often discarded, with gastric aspiration accounting for ~9% of lungs unsuitable for transplantation. To increase the donor pool, it is important to understand the pathophysiology of aspiration-induced lung damage (AILD) an
Externí odkaz:
https://doaj.org/article/701914ac0e3b4994bb04ea75d7718910
Autor:
Anna Spreafico, Eva Muñoz Couselo, Anja Irmisch, Juliana Bessa, George Au-Yeung, Oliver Bechter, Inge Marie Svane, Miguel F. Sanmamed, Valentina Gambardella, Meredith McKean, Margaret Callahan, Reinhard Dummer, Christian Klein, Pablo Umaña, Nicole Justies, Florian Heil, Linda Fahrni, Eugenia Opolka-Hoffmann, Inja Waldhauer, Conrad Bleul, Roland F. Staack, Vaios Karanikas, Stephen Fowler
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionAlthough checkpoint inhibitors (CPIs) have improved outcomes for patients with metastatic melanoma, those progressing on CPIs have limited therapeutic options. To address this unmet need and overcome CPI resistance mechanisms, novel immun
Externí odkaz:
https://doaj.org/article/1b6cf328c2214d24859fac4cbcd710e0
Autor:
Bianca Lascaris, MD, Roland F. Hoffmann, PhD, Maarten W.N. Nijsten, MD, PhD, Robert J. Porte, MD, PhD, Vincent E. de Meijer, MD, PhD
Publikováno v:
Transplantation Direct, Vol 10, Iss 2, p e1568 (2024)
Background. Normothermic machine perfusion (NMP) is used to preserve and test donor livers before transplantation. During NMP, the liver is metabolically active and produces waste products, which are released into the perfusate. In this study, we des
Externí odkaz:
https://doaj.org/article/e2edf4835d1d483f9e790f2d9b878a50
Autor:
Arsenios Vlassis, Tanja L. Jensen, Marina Mohr, Dominika J. Jedrzejczyk, Xiangyou Meng, Gergo Kovacs, Martí Morera-Gómez, Andrea Barghetti, Sergi Muyo Abad, Roland F. Baumgartner, Kedar N. Natarajan, Lars K. Nielsen, Tanya Warnecke, Ryan T. Gill
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108287- (2023)
Summary: Discovery of genomic safe harbor sites (SHSs) is fundamental for multiple transgene integrations, such as reporter genes, chimeric antigen receptors (CARs), and safety switches, which are required for safe cell products for regenerative cell
Externí odkaz:
https://doaj.org/article/1ed7e3c6b32b4486a833882c76203d11