Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Roland E. Kontermann"'
Autor:
Kayla L. Nguyen, Ishaan J. Bhatt, Shruti Gupta, Nazaf Showkat, Kathryn A. Swanson, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Valerie Bracchi-Ricard, John R. Bethea
Publikováno v:
Brain Research Bulletin, Vol 207, Iss , Pp 110885- (2024)
Multiple sclerosis (MS), a demyelinating autoimmune disease of the central nervous system (CNS), predominately affects females compared to males. Tumor necrosis factor (TNF), a pro-inflammatory cytokine, signaling through TNF receptor 1 contributes t
Externí odkaz:
https://doaj.org/article/667057d00d2a42bdb40ed215236bb75d
Autor:
Lennart Kühl, Annelie K. Schäfer, Sebastian Kraft, Nadine Aschmoneit, Roland E. Kontermann, Oliver Seifert
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBispecific antibodies are molecules with versatile modes of action and applications for therapy. They are commonly developed as T-cell engagers (TCE), which simultaneously target an antigen expressed by tumor cells and CD3 expressed by T-cell
Externí odkaz:
https://doaj.org/article/dedeb020f41f452187e36cd60d89c9b7
Autor:
Natalia Ortí-Casañ, Ate S. Boerema, Karina Köpke, Amber Ebskamp, Jan Keijser, Yuequ Zhang, Tingting Chen, Amalia M. Dolga, Kerensa Broersen, Roman Fischer, Klaus Pfizenmaier, Roland E. Kontermann, Ulrich L. M. Eisel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the t
Externí odkaz:
https://doaj.org/article/c98638b7b125423496722b05327a5864
Autor:
Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. TNF-TNFRs signaling orchestrates importan
Externí odkaz:
https://doaj.org/article/5841bf7052c54683ab34c56469546a89
Autor:
Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem, Sarah K. Williams
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing biological effects, which may explain the lack of therapeutic potential ob
Externí odkaz:
https://doaj.org/article/419220a7d4354d2c8e22cb1683c5790a
Autor:
Leila Abassi, Federico Bertoglio, Željka Mačak Šafranko, Thomas Schirrmann, Marina Greweling-Pils, Oliver Seifert, Fawad Khan, Maeva Katzmarzyk, Henning Jacobsen, Natascha Gödecke, Philip Alexander Heine, André Frenzel, Helena Nowack, Stefan Dübel, Ivan-Christian Kurolt, Roland E. Kontermann, Alemka Markotić, Maren Schubert, Michael Hust, Luka Čičin-Šain
Publikováno v:
Viruses, Vol 15, Iss 11, p 2153 (2023)
As of now, the COVID-19 pandemic has spread to over 770 million confirmed cases and caused approximately 7 million deaths. While several vaccines and monoclonal antibodies (mAb) have been developed and deployed, natural selection against immune recog
Externí odkaz:
https://doaj.org/article/077b33dc2676465b9909db3b22cbe422
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Bispecific antibodies have emerged as therapeutic molecules with a multitude of modes of action and applications. Here, we present a novel approach to solve the light-chain problem for the generation of bispecific Ig-like antibodies using the second
Externí odkaz:
https://doaj.org/article/cd764e6089e841b09a9a9bf18df4cbbd
Autor:
Nadine Aschmoneit, Katharina Kocher, Martin Siegemund, Martina S. Lutz, Lennart Kühl, Oliver Seifert, Roland E. Kontermann
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Targeting costimulatory receptors of the tumor necrosis factor superfamily (TNFSF) to activate T-cells and promote anti-tumor T-cell function have emerged as a promising strategy in cancer immunotherapy. Previous studies have shown that combining two
Externí odkaz:
https://doaj.org/article/576ebae1bf8c4fda872afd57290e2490
Autor:
Greta Del Mistro, Shamala Riemann, Sebastian Schindler, Stefan Beissert, Roland E. Kontermann, Aurelien Ginolhac, Rashi Halder, Luana Presta, Lasse Sinkkonen, Thomas Sauter, Dagmar Kulms
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Despite remarkable advances in therapeutic interventions, malignant melanoma (MM) remains a life-threating disease. Following high initial response rates to targeted kinase-inhibition metastases quickly acquire resistance and present with en
Externí odkaz:
https://doaj.org/article/9778265ac8ac49fab1e3c0b061d09e03
Autor:
Irini Papazian, Eleni Tsoukala, Athena Boutou, Maria Karamita, Konstantinos Kambas, Lida Iliopoulou, Roman Fischer, Roland E. Kontermann, Maria C. Denis, George Kollias, Hans Lassmann, Lesley Probert
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-21 (2021)
Abstract Background During inflammatory demyelination, TNF receptor 1 (TNFR1) mediates detrimental proinflammatory effects of soluble TNF (solTNF), whereas TNFR2 mediates beneficial effects of transmembrane TNF (tmTNF) through oligodendroglia, microg
Externí odkaz:
https://doaj.org/article/f835375dd4814f7eb875ab3d9fd3f00f