Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Roland E Dolle"'
Autor:
Callum AH Docherty, Anuruddika J Fernando, Sarah Rosli, Maggie Lam, Roland E Dolle, Manuel A Navia, Ronald Farquhar, Danny La France, Michelle D Tate, Christopher K Murphy, Adriano G Rossi, Ashley Mansell
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Objectives Inflammasomes induce maturation of the inflammatory cytokines IL‐1β and IL‐18, whose activity is associated with the pathophysiology of a wide range of infectious and inflammatory diseases. As validated therapeutic targets fo
Externí odkaz:
https://doaj.org/article/f402fa42dc57419ea86338a42ffe4836
Autor:
Young Mi Oh, Seong Won Lee, Woo Kyung Kim, Shawei Chen, Victoria A. Church, Kitra Cates, Tiandao Li, Bo Zhang, Roland E. Dolle, Sonika Dahiya, Stephen C. Pak, Gary A. Silverman, David H. Perlmutter, Andrew S. Yoo
Publikováno v:
Nature Neuroscience. 25:1420-1433
Autor:
Hoyer Denton W, Anna‐Lena Gustavsson, Vadim J. Gurvich, Al Edwards, Paul D. Andrews, Daniel Ebner, Stephen Frye, Denise Barrault, Erik Chorell, Peter I. Dosa, Neil O. Carragher, Michael R. Myers, Gunda I. Georg, Hirotatsu Kojima, Andrew M. Hopkins, Richard E. Taylor, Michael A. Walters, Roland E. Dolle, Jon E. Hawkinson
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
The SARS-CoV-2 (COVID-19) pandemic was officially declared by the World Health Organization on 11 March, 2020. From the initial public reports from China in December 2019, the contagion blazed its way from ground zero in Wuhan, China into 165 countri
Autor:
Choongheon Lee, Alec N. Salt, Mark A. Rutherford, Shawn S. Goodman, Jared J. Hartsock, Amit Walia, Roland E. Dolle, Jeffery T. Lichtenhan
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Hearing depends on glutamatergic synaptic transmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). AMPARs are tetramers, where inclusion of the GluA2 subunit reduces overall channel conductance and Ca2+ perme
Autor:
Antonietta Franco, Gerald W. Dorn, Agostinho G. Rocha, Xiawei Dang, Jiajia Li, Lihong Zhang, Peter R. Bernstein, Roland E. Dolle, Sriram Devanathan
Publikováno v:
J Med Chem
Mutations in the mitochondrial fusion protein mitofusin (MFN) 2 cause the chronic neurodegenerative condition Charcot-Marie-Tooth Disease type 2A (CMT2A), for which there is currently no treatment. Small molecule activators of MFN1 and MFN2 enhance m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11140b470725cf4bac918493c1b304d
https://europepmc.org/articles/PMC7731667/
https://europepmc.org/articles/PMC7731667/
Autor:
Anastasiia Pendergrass, Thijn R. Brummelkamp, India C Bradley, Jiwoong Park, Niki Song, Nicholas L Bean, Jinmei Li, Sandeep Kumar, Nicholas C Jacobs, Ariella Coler-Reilly, Roland E. Dolle, Damon T. Burrow, Malini Varadarajan, Timothy R. Peterson, Tanya H Pierre, Jan E. Carette, Sydney K Hart
Chloroquine is an anti-malarial and immunosuppressant drug that has cationic amphipathic chemical properties. We performed genome-wide screens in human cells with chloroquine and several other widely used cationic amphipathic drugs (CADs) including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072420f8c7d34ecdaba1d0254430ac42
https://doi.org/10.1101/2020.04.10.035683
https://doi.org/10.1101/2020.04.10.035683
Autor:
Xiawei Dang, Lihong Zhang, Antonietta Franco, Jiajia Li, Agostinho G. Rocha, Sriram Devanathan, Roland E. Dolle, Peter R. Bernstein, Gerald W. Dorn
Publikováno v:
Journal of Medicinal Chemistry. 63:10086-10086
Autor:
Kien T. Nguyen, Chester A. Metcalf, Douglas Bevan, Jan Antoinette C. Romero, Bin Wang, Dominic Ryan, Jing Zhang, Jared Silverman, Felix Epie, Anu Daniel, Nicole M. Carter, Terence Moy, Yanzhi Zhang, Jason B. Cross, Ajit Chavan, Lippa Blaise S, Qingyi Yang, Katherine M. Poutsiaka, Joseph Shotwell, Roland E. Dolle, Brian Chamberlain, Xin Zhang
Publikováno v:
Journal of Medicinal Chemistry. 58:8503-8512
The emergence and spread of multidrug resistant bacteria are widely believed to endanger human health. New drug targets and lead compounds exempt from cross-resistance with existing drugs are urgently needed. We report on the discovery of azaindole u
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Autor:
Jan Antoinette C. Romero, Michael F. Mesleh, Douglas Bevan, Joseph Shotwell, Ole A. Andersen, Kien T. Nguyen, Bin Wang, Jing Zhang, Katherine M. Poutsiaka, Qingyi Yang, Anu Daniel, Brian Chamberlain, Lippa Blaise S, Nicole M. Carter, Roland E. Dolle, Terence Moy, Chester A. Metcalf, Jason B. Cross, John J. Barker, M. Dominic Ryan, Jared Silverman, Felix Epie
The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class of pyrazolopyridone inhibitors was discovered by optimizing a fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461bdfd2f15b29c8a0f1afd5fa1ba2d4
https://europepmc.org/articles/PMC4834655/
https://europepmc.org/articles/PMC4834655/