Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Roland D. Ciaranello"'
Autor:
Linda Lotspeich, William M. McMahon, P. Brent Petersen, Peter Nicholas, Roland D. Ciaranello, Donna Spiker, C. Pingree, Joachim Hallmayer
Publikováno v:
American Journal of Medical Genetics. 67:13-18
Despite strong genetic influences in autism, the true mode of inheritance remains unknown. Sex differences in autism have been described in both singleton and multiplex families [Lord et al., 1982; Volkmar et al., 1993; McLennan et al., 1993; Lord, 1
Autor:
Roland D. Ciaranello, Pingyu Zhong
Publikováno v:
Molecular Brain Research. 29:23-34
5-HT1a receptors in the hippocampus play a critical role in modulating limbic system output. The activity and level of 5-HT1a receptors are modulated by glucocorticoid levels. The present study was undertaken to test the hypothesis that glucocorticoi
Autor:
Donna Spiker, Linda Lotspeich, Helena C. Kraemer, Joachim Hallmayer, William McMahon, P. Brent Petersen, Peter Nicholas, Carmen Pingree, Susan Wiese-Slater, Carla Chiotti, Dona Lee Wong, Susan Dimicelli, Edward Ritvo, Luigi L. Cavalli-Sforza, Roland D. Ciaranello
Publikováno v:
American Journal of Medical Genetics. 54:27-35
Evidence from twin and family studies strongly suggests that genetic factors play a prominent role in the etiology of some cases of infantile autism. Genetic factors would be expected to be especially strong in families with multiple autistic members
Autor:
Roland D. Ciaranello, David A Morilak
Publikováno v:
Neuroscience. 55:869-880
In this study, we investigated the regional and temporal emergence of 5-hydroxytryptamine2 receptor immunoreactivity in the developing rat brain. In a qualitative immunocytochemical analysis using an antibody against the rat 5-hydroxytryptamine2 rece
Publikováno v:
Neuroscience. 54:701-717
Serotonin2 receptors have been implicated in a variety of behavioral and physiological processes, as well as a number of neuropsychiatric disorders. To specify the brain regions and specific cell types possessing serotonin2 receptors, we conducted an
Autor:
Reid, William C. Dement, Emmanuel Mignot, Jerome M. Siegel, LH Sharp, Dale M. Edgar, Roland D. Ciaranello, Seiji Nishino, Janis Arrigoni
Publikováno v:
The Journal of Neuroscience. 13:1057-1064
Narcolepsy is a genetically determined disorder of sleep characterized by excessive daytime sleepiness and abnormal manifestations of REM sleep that affects both humans and animals. Although its exact pathophysiologic mechanisms remain undetermined,
Autor:
Matthew H. Porteus, Ted B. Usdin, Alessandro Bulfone, A.Elizabeth J. Brice, John L.R. Rubenstein, Roland D. Ciaranello
Publikováno v:
Molecular Brain Research. 12:7-22
In order to isolate genes involved in development of the mammalian telencephalon we employed an efficient cDNA library procedure. By subtracting an adult mouse telencephalic cDNA library from an embryonic day 15 (E15) mouse telencephalic cDNA library
Autor:
Roland D. Ciaranello
Publikováno v:
New Directions for Mental Health Services. 1992:9-17
Normal brain development involves a series of exquisitely complex and highly orchestrated events; disruptions in normal brain development provide a useful model for understanding infantile autism and other pervasive developmental disorders.
Autor:
Bryan L. Roth, Roland D. Ciaranello
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 207:169-172
Rats were injected with 15 mg/kg (i.p.) mianserin or vehicle (saline) for 4, 10 or 21 days and 5-HT2 receptor binding and mRNA levels measured. Treatment with mianserin induced a substantial decrease in 5-HT2 radioligand binding (44-59% decrease; P l
Publikováno v:
Annual Review of Medicine. 42:151-158
We review recent studies on the inheritance of affective disorders and schizophrenia. Both groups of diseases have substantial genetic and nongenetic components, and their inheritance does not fit simple Mendelian models. Linkage studies implicate th