Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Roland C, Grafström"'
Autor:
Verónica I. Dumit, Yuk‐Chien Liu, Aileen Bahl, Pekka Kohonen, Roland C. Grafström, Penny Nymark, Christine Müller‐Graf, Andrea Haase, Mario Pink
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract The Fiber Pathogenicity Paradigm (FPP) establishes connections between fiber structure, durability, and disease‐causing potential observed in materials like asbestos and synthetic fibers. While emerging nanofibers are anticipated to exhibi
Externí odkaz:
https://doaj.org/article/6b63502ec35944bbb92b3cb3094902c0
Autor:
Pekka Kohonen, Juuso A. Parkkinen, Egon L. Willighagen, Rebecca Ceder, Krister Wennerberg, Samuel Kaski, Roland C. Grafström
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Predicting the hepatotoxic effects of new drugs is still a challenge. Using toxicogenomics data, the authors here define a predictive toxicogenomic space (PTGS), the component gene space capturing dose-dependent cytotoxicity, and demonstrate that it
Externí odkaz:
https://doaj.org/article/b3ffbdb2495c4ed780e332c2488fb16b
Autor:
Olli Kallioniemi, Merja Perälä, Roland C. Grafström, Vidal Fey, Pekka Kohonen, Pasi Halonen, Paula Vainio, Kirsi Ketola, Kristiina Iljin
Supplementary Data from High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3917bf7ae73958f4ba0dd75a40f147
https://doi.org/10.1158/1078-0432.22440433
https://doi.org/10.1158/1078-0432.22440433
Autor:
Olli Kallioniemi, Merja Perälä, Roland C. Grafström, Vidal Fey, Pekka Kohonen, Pasi Halonen, Paula Vainio, Kirsi Ketola, Kristiina Iljin
Purpose: To identify novel therapeutic opportunities for patients with prostate cancer, we applied high-throughput screening to systematically explore most currently marketed drugs and drug-like molecules for their efficacy against a panel of prostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bf9c86799cf4642208892147e571e7
https://doi.org/10.1158/1078-0432.c.6517762.v1
https://doi.org/10.1158/1078-0432.c.6517762.v1
Autor:
Vesselina Paskaleva, Nicolas Manier, Vedrin Jeliazkov, Penny Nymark, Keld Alstrup Jensen, Peter Ritchie, Maria Dusinska, Nicklas Raun Jacobsen, Pekka Kohonen, Margarita D. Apostolova, Nikolay Kochev, Elise Rundén-Pran, Isabel Rodríguez Llopis, Agnieszka Mech, Naouale El Yamani, Andrea Haase, Cristina Andreoli, Isabella De Angelis, Speranta Tanasescu, Aurica Precupas, Flavia Barone, Chiara Laura Battistelli, Kirsten Rasmussen, Tomasz Puzyn, José María Navas, Roland C. Grafström, Daniela Gheorghe, Cecilia Bossa, Maciej Gromelski, Paloma Gómez-Fernández, Espen Mariussen, Alina Botea-Petcu, Anna Giusti, Andrew Barrick, Romica Sandu, Neeraj Shandilya, Nina Jeliazkova, Amélie Châtel
Publikováno v:
Nature Nanotechnology
Nature Nanotechnology, Nature Publishing Group, 2021, 16 (6), pp.644-654. ⟨10.1038/s41565-021-00911-6⟩
Nature Nanotechnology, Nature Publishing Group, 2021, 16 (6), pp.644-654. ⟨10.1038/s41565-021-00911-6⟩
13 Pág. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
Nanotechnology is a key enabling technology with billions of euros in global investment from public funding, which include large collaborative projects that have i
Nanotechnology is a key enabling technology with billions of euros in global investment from public funding, which include large collaborative projects that have i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f42e13f25b65b36e5bcffc9f0e07c4
http://hdl.handle.net/10261/288155
http://hdl.handle.net/10261/288155
Autor:
Noelia Ramirez, Iseult Lynch, Nikolaos S. Thomaidis, Ralf J. M. Weber, Hilda Witters, Evan E Bolton, Antony Williams, Pavel Babica, Susanna-Assunta Sansone, Kasia Arturi, Anže Županič, Gerard J.P. van Westen, Karine Audouze, Sergio Martinez Cuesta, Tobias Schulze, Jos Bessems, Dimitrios Damalas, Montserrat Cases, Penny Nymark, Ferran Sanz, Uko Maran, Haralambos Sarimveis, Ludek Blaha, Jaroslav Slobodnik, Jos C. S. Kleinjans, Todor Kondic, Hristo Aladjov, Egon Willighagen, Hervé Ménager, Brett Sallach, Danyel Jennen, Sirarat Sarntivijai, Roland C. Grafström, Rob Stierum, Jonathan Tedds, John M. Hancock, Reza M. Salek, Boï Kone, Karel Berka, Herbert Oberacher, Craig E. Wheelock, Steffen Neumann, Alasdair J. G. Gray, Pascal Kahlem, Sylvie Remy, Emma L. Schymanski, Marco Dilger, Ola Spjuth, Barbara Zdrazil, Marvin Martens, Kirtan Dave, Jana Klánová, Henner Hollert, Daan P. Geerke, Philippe Rocca-Serra, Nina Jeliazkova, Thomas Exner, Chris T. Evelo, Fabien Jourdan, Reza Aalizadeh
Publikováno v:
F1000Research
F1000Research, 2021, 10, pp.1129. ⟨10.12688/f1000research.74502.1⟩
F1000Research, 10:1129. F1000 Research Ltd
F1000Research, 2021, 10, pp.1129. ⟨10.12688/f1000research.74502.1⟩
F1000Research, 10:1129. F1000 Research Ltd
International audience; Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfb35debcfa39b9d8a61ded7efa15ea
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485906
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485906
Autor:
Magnus L Hansson, Stefanie Behmer, Rebecca Ceder, Sadollah Mohammadi, Giulio Preta, Roland C Grafström, Bengt Fadeel, Annika E Wallberg
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46001 (2012)
Mastermind-like 1 (MAML1) is a transcriptional coregulator of activators in various signaling pathways, such as Notch, p53, myocyte enhancer factor 2C (MEF2C) and beta-catenin. In earlier studies, we demonstrated that MAML1 enhanced p300 acetyltransf
Externí odkaz:
https://doaj.org/article/ad797bafaafa428db0051574225f02dd
Autor:
Abirami Rajarajan, Angela Stokes, Balvinder K Bloor, Rebecca Ceder, Hemini Desai, Roland C Grafström, Edward W Odell
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28776 (2012)
Expression of CD44, a transmembrane hyaluronan-binding glycoprotein, is variably considered to have prognostic significance for different cancers, including oral squamous cell carcinoma. Although unclear at present, tissue-specific expression of part
Externí odkaz:
https://doaj.org/article/511ffbf83fab489a8fe51505c419a0b3
Autor:
Chris T. Evelo, Friederike Ehrhart, Nina Jeliazkova, Penny Nymark, Haralambos Sarimveis, Pekka Kohonen, Georgia Tsiliki, Linda Rieswijk, Roland C. Grafström, Egon Willighagen, Vesa Hongisto
Publikováno v:
Toxicological Sciences, 162(1), 264-275. Oxford University Press
Toxicological Sciences
Toxicological Sciences
Increasing amounts of systems toxicology data, including omics results, are becoming publically available and accessible in databases. Data-driven and informatics-tool supported pipeline schemas for fitting such data into Adverse Outcome Pathway (AOP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b4224cffc99a3bdf3d8b3140b1e107
https://doi.org/10.1093/toxsci/kfx252
https://doi.org/10.1093/toxsci/kfx252
Autor:
Dimitra-Danai Varsou, Pekka Kohonen, Penny Nymark, Roland C. Grafström, Georgia Tsiliki, Haralambos Sarimveis
Publikováno v:
Journal of Chemical Information and Modeling. 58:543-549
We present toxFlow, a web application developed for enrichment analysis of omics data coupled with read-across toxicity prediction. A sequential analysis workflow is suggested where users can filter omics data using enrichment scores and incorporate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf8fceacd563c3302bee1c073e62835
https://doi.org/10.1021/acs.jcim.7b00160
https://doi.org/10.1021/acs.jcim.7b00160