Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Roland Böttger"'
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1696 (2021)
Colorectal cancer with peritoneal metastases is currently treated by cytoreductive surgery and locoregional chemotherapeutics. This standard treatment is associated with high morbidity, mortality, and recurrence rate. To augment the existing therapy,
Externí odkaz:
https://doaj.org/article/1a8d0c531bec43ae8bb65fea3be92be6
Autor:
K. K. DurgaRao Viswanadham, Roland Böttger, Lukas Hohenwarter, Anne Nguyen, Elham Rouhollahi, Alexander Smith, Yi-Hsuan Tsai, Yuan-Yu Chang, Christopher Llynard Ortiz, Lee-Wei Yang, Liliana Jimenez, Siyuan Li, Chan Hur, Shyh-Dar Li
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 927 (2021)
Opioids account for 69,000 overdose deaths per annum worldwide and cause serious side effects. Safer analgesics are urgently needed. The endogenous opioid peptide Leu-Enkephalin (Leu-ENK) is ineffective when introduced peripherally due to poor stabil
Externí odkaz:
https://doaj.org/article/4621f9b11dd548d1a9c098ff17bdc595
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178943 (2017)
Proteolytic degradation of peptide-based drugs is often considered as major weakness limiting systemic therapeutic applications. Therefore, huge efforts are typically devoted to stabilize sequences against proteases present in serum or plasma, obtain
Externí odkaz:
https://doaj.org/article/57f257a88be345d08ef526aa7adfe618
Autor:
Nojoud AL Fayez, Elham Rouhollahi, Chun Yat Ong, Jiamin Wu, Anne Nguyen, Roland Böttger, Pieter R. Cullis, Dominik Witzigmann, Shyh-Dar Li
Publikováno v:
Journal of Controlled Release. 350:630-641
Hepatitis B virus (HBV) can rapidly replicate in the hepatocytes after transmission, leading to chronic hepatitis, liver cirrhosis and eventually hepatocellular carcinoma. Interferon-α (IFN-α) is included in the standard treatment for chronic hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e29c8d5b9c67f4b9e96df9bdaa22563
https://doi.org/10.1016/j.jconrel.2022.08.058
https://doi.org/10.1016/j.jconrel.2022.08.058
Autor:
Roland Böttger, Po-Han Chao, Nojoud AL Fayez, Griffin Pauli, Anne Nguyen, Lukas Hohenwarter, Nida Bilal, Gubran Khalil Mohammed, Daniel Knappe, Ralf Hoffmann, Shyh-Dar Li
Publikováno v:
Molecular Pharmaceutics. 19:1882-1891
Nanomedicines including lipid- and polymer-based nanoparticles and polymer-drug conjugates enable targeted drug delivery for the treatment of numerous diseases. Quantitative analysis of components in nanomedicines is routinely performed to characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a59050feb4bf9cf3ae6f9d51580b2d
https://doi.org/10.1021/acs.molpharmaceut.2c00021
https://doi.org/10.1021/acs.molpharmaceut.2c00021
Autor:
Anne Nguyen, Elham Rouhollahi, Roland Böttger, Chun Yat Ong, Po-Han Chao, Jiamin Wu, Yao Chen, Shyh-Dar Li
Publikováno v:
Biomaterials Science. 10:3122-3136
Poorly water-soluble small hydrophobic compounds can be conjugated to a hydrophilic polymer such as methoxypolyethylene glycol (mPEG) to form amphiphilic prodrugs that can self-assemble into nanoparticles (NPs) with increased aqueous solubility, prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea6f289d71cd6c8ffdf28313832cac0
https://doi.org/10.1039/d1bm01947c
https://doi.org/10.1039/d1bm01947c
Autor:
Gubran Khalil Mohammed, Roland Böttger, Andor Krizsan, Daniela Volke, Marina Mötzing, Shyh‐Dar Li, Daniel Knappe, Ralf Hoffmann
Publikováno v:
Advanced Healthcare Materials. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36571401f38c42541ca1b9700a3c081b
https://doi.org/10.1002/adhm.202202368
https://doi.org/10.1002/adhm.202202368
Publikováno v:
International journal of pharmaceutics. 628
Phospholipid-free small unilamellar vesicles (PFSUVs) composed of cholesterol and TWEEN80 (5:1 mol ratio), with an average diameter of 60 nm, displayed targeted delivery to the hepatocytes after intravenous (i.v.) injection. Here, we conducted a seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31292154c55d10c7110d2c1a4dd015b
https://pubmed.ncbi.nlm.nih.gov/36220590
https://pubmed.ncbi.nlm.nih.gov/36220590
Autor:
Nojoud AL Fayez, Roland Böttger, Sreemoyee Ghosh, Yushi Nakajima, Po-Han Chao, Elham Rouhollahi, Anne Nguyen, Pieter R. Cullis, Dominik Witzigmann, Shyh-Dar Li
Publikováno v:
International journal of pharmaceutics. 625
Many medicines are only available in solid dosage forms suitable for adults, and extemporaneous compounding is required to prepare formulations for children. However, this common practice often results in inaccurate dosing and unpleasant taste, reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb4f5350f5e6804026569309512b192
https://pubmed.ncbi.nlm.nih.gov/35964828
https://pubmed.ncbi.nlm.nih.gov/35964828
Publikováno v:
Pharmaceutics, Vol 13, Iss 1696, p 1696 (2021)
Pharmaceutics
Volume 13
Issue 10
Pharmaceutics
Volume 13
Issue 10
Colorectal cancer with peritoneal metastases is currently treated by cytoreductive surgery and locoregional chemotherapeutics. This standard treatment is associated with high morbidity, mortality, and recurrence rate. To augment the existing therapy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f673fba19aca5937a57925e00738cd
https://www.mdpi.com/1999-4923/13/10/1696
https://www.mdpi.com/1999-4923/13/10/1696