Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Roland A. Pache"'
Autor:
Roland A. Pache, Patrick Aloy
Publikováno v:
PeerJ, Vol 2, p e413 (2014)
Macromolecular assemblies play an important role in almost all cellular processes. However, despite several large-scale studies, our current knowledge about protein complexes is still quite limited, thus advocating the use of in silico predictions to
Externí odkaz:
https://doaj.org/article/99fe9468bcfe4e67837ae584582f14e3
Autor:
Cody Krivacic, Kale Kundert, Xingjie Pan, Roland A. Pache, Lin Liu, Shane O Conchúir, Jeliazko R. Jeliazkov, Jeffrey J. Gray, Michael C. Thompson, James S. Fraser, Tanja Kortemme
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 11
Significance Computational protein design promises to advance applications in medicine and biotechnology by creating proteins with many new and useful functions. However, new functions require the design of specific and often irregular atom-level geo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e17a02cd4f0e5e7311d3e1aad566623
https://escholarship.org/uc/item/3452f0h6
https://escholarship.org/uc/item/3452f0h6
Autor:
Shane Ó Conchúir, Kyle A Barlow, Roland A Pache, Noah Ollikainen, Kale Kundert, Matthew J O'Meara, Colin A Smith, Tanja Kortemme
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0130433 (2015)
The development and validation of computational macromolecular modeling and design methods depend on suitable benchmark datasets and informative metrics for comparing protocols. In addition, if a method is intended to be adopted broadly in diverse bi
Externí odkaz:
https://doaj.org/article/1f949fb55f484b8db27a3fc860f872d1
Autor:
Cody Krivacic, Michael C. Thompson, Roland A. Pache, Kale Kundert, Xingjie Pan, Tanja Kortemme, Lin Liu, James S. Fraser, Jeffrey J. Gray, Jeliazko R. Jeliazkov, Shane Ó Conchúir
Accurate positioning of functional residues is critical for the design of new protein functions, but has remained difficult because of the prevalence of irregular local geometries in active sites. Here we introduce two computational methods that buil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dadf9ee1c54768e444e02d750bf9d7d
https://doi.org/10.1101/2021.07.02.450934
https://doi.org/10.1101/2021.07.02.450934
Autor:
Michael C. Thompson, Tanja Kortemme, Daniel J. Mandell, Kyle A. Barlow, Jenna Pellegrino, Yao-Ming Huang, James S. Fraser, Amanda L. Loshbaugh, Anum A. Glasgow, Noah Ollikainen, Mark J. S. Kelly, Ryan Ritterson, Cody Krivacic, Deborah Jeon, Roland A. Pache
Publikováno v:
Science
Science (New York, N.Y.), vol 366, iss 6468
Science (New York, N.Y.), vol 366, iss 6468
Sense and respond Many signaling pathways start with cellular proteins sensing and responding to small molecules. Despite advances in protein design, creating a protein-based sense-and-respond system remains challenging. Glasgow et al. designed bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3b5ab92ce33debbe89d63e90254e35
https://europepmc.org/articles/PMC7343396/
https://europepmc.org/articles/PMC7343396/
Autor:
Tanja Kortemme, Nathan D. Thomsen, James A. Wells, Graeme W. Davis, Roland A. Pache, Ashley D. Smart
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 39
The circuitry of the brain is characterized by cell heterogeneity, sprawling cellular anatomy, and astonishingly complex patterns of connectivity. Determining how complex neural circuits control behavior is a major challenge that is often approached
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e007df78f6587ab7c541ac70e9b8d9
https://escholarship.org/uc/item/8gb0g547
https://escholarship.org/uc/item/8gb0g547
Publikováno v:
Nucleic Acids Research
The many ongoing genome sequencing initiatives are delivering comprehensive lists of the individual molecular components present in an organism, but these reveal little about how they work together. Follow-up initiatives are revealing thousands of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090308ed4c79f7f7d8bf5b880cd179e7
https://doi.org/10.1093/nar/gks446
https://doi.org/10.1093/nar/gks446
Publikováno v:
EMBO reports. 11:977-984
Aurora A is a serine/threonine kinase that is essential for a wide variety of cell-cycle-related events, but only a small number of its substrates are known. We present and validate a strategy by which to identify Aurora A substrates and their phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4ae61bc82844771c224c9bb3bb5bca
https://doi.org/10.1038/embor.2010.171
https://doi.org/10.1038/embor.2010.171
Autor:
Patrick Aloy, Roland A. Pache
Publikováno v:
PROTEOMICS. 8:1959-1964
The last years have seen the emergence of many large-scale proteomics initiatives that have identified thousands of new protein interactions and macromolecular assemblies. However, unfortunately, only a few among the discovered complexes meet the hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d189eeff35cca6a1b0ad880482395a
https://doi.org/10.1002/pmic.200700966
https://doi.org/10.1002/pmic.200700966
Publikováno v:
FEBS Letters. 582:1259-1265
The dominant conceptual reductionism in drug discovery has resulted in many promising drug candidates to fail during the last clinical phases, mainly due to a lack of knowledge about the patho-physiological pathways they are acting on. Consequently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc234d2e728b6779f12ba0377c40dda
https://doi.org/10.1016/j.febslet.2008.02.014
https://doi.org/10.1016/j.febslet.2008.02.014