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pro vyhledávání: '"Roland Tacke"'
Autor:
Roland Tacke, Hagop M. Kantarjian, Rami S. Komrokji, Ruben A. Mesa, Claire N. Harrison, Richard T. Silver
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 13:638-645
Myelofibrosis (MF), associated with a Philadelphia chromosome-negative myeloproliferative neoplasms, is characterized by progressive bone marrow fibrosis and ineffective hematopoiesis. Clinical hallmarks include splenomegaly, anemia, and debilitating
Autor:
James L. Manley, Roland Tacke
Publikováno v:
Current Opinion in Cell Biology. 11:358-362
The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such
Autor:
James L. Manley, Roland Tacke
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. 220:59-63
Alternative pre-mRNA splicing is a powerful mechanism of gene expression control in eukaryotic cells that can influence cell function, cellular differentiation, and development. In some instances, as exemplified by the sex-specific regulation of tran
Publikováno v:
Cell. 93(1):139-148
The RNA-binding protein Tra2 is an important regulator of sex determination in Drosophila. Recently, two mammalian Tra2 homologs of unknown function have been described. Here, we show that human Tra2 proteins are present in HeLa cell nuclear extracts
Publikováno v:
Proceedings of the National Academy of Sciences. 94:1148-1153
We showed previously that ASF/SF2, a member of the SR protein family of splicing factors, can activate a splicing enhancer element composed of high-affinity ASF/SF2 binding sites. To determine whether other SR proteins can behave similarly, we select
Autor:
Rudolf Martini, Roland Tacke
Publikováno v:
Neuroscience Letters. 120:227-230
The relative amounts of transcripts specific for the adhesive molecule L1 and the neural cell adhesion molecule (NCAM) in the distal stump of transected rat sciatic nerves were determined by quantitative Northern blot analysis during the first four w
Publikováno v:
Differentiation. 44:42-55
We have previously studied the immunohisto-logical localization of the three adhesion molecules L1, N-CAM and J1/tenascin in adult mouse small intestine and shown that L1 expression in epithelial crypt cells underlies the adhesion of these cells to o
Autor:
Peter Haytko, Mei Cong, Thomas Livelli, Zhong Zhong, Mark Federici, Roland Tacke, Natalie Fursov, Michael Platchek
Publikováno v:
Assay and drug development technologies. 3(1)
In this article we describe the use of division-arrested cells for cell-based assays designed for high-throughput screening. Cells are the most critical and variable reagent for cell-based high-throughput screening. The robustness of robotic screenin
Publikováno v:
Scopus-Elsevier
RNA polymerase II (RNAP II) is responsible for transcription of mRNA precursors in eukaryotic cells. Recent studies, however, have suggested that RNAP II also participates in subsequent RNA processing reactions through interactions between the carbox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c3b8de5359306a0bb916d44842aae9
https://europepmc.org/articles/PMC316731/
https://europepmc.org/articles/PMC316731/
Publikováno v:
The Journal of biological chemistry. 270(8)
In the gene of the neural cell adhesion molecule, the 5′ splice site of the alternate exon 18 plays an important role in establishing regulated splicing profiles. To understand how the 5′ splice site of exon 18 contributes to splicing regulation,