Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Roland Reinehr"'
Autor:
Paul Dent, Steven Grant, Paul B. Fisher, Christina Voelkel-Johnson, Roland Reinehr, Dieter Häussinger, Mohamed Rahmani, Adly Yacoub, Margaret A. Park, Clint Mitchell, Teneille Walker
Supplementary Data from 17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339bda2c37c9ffeb804512ea476f32c1
https://doi.org/10.1158/1535-7163.22486049
https://doi.org/10.1158/1535-7163.22486049
Autor:
Paul Dent, Steven Grant, Adly Yacoub, Besim Ogretmen, Christina Voelkel-Johnson, Dieter Häussinger, Roland Reinehr, Margaret A. Park
Supplementary Data from Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c825d3c7d00342dadf52314ec34a8f0
https://doi.org/10.1158/1535-7163.22485444.v1
https://doi.org/10.1158/1535-7163.22485444.v1
Autor:
Paul Dent, Steven Grant, Paul B. Fisher, Christina Voelkel-Johnson, Roland Reinehr, Dieter Häussinger, Mohamed Rahmani, Adly Yacoub, Margaret A. Park, Clint Mitchell, Teneille Walker
The present studies determine in greater detail the molecular mechanisms upstream of the CD95 death receptor by which geldanamycin heat shock protein 90 inhibitors and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e00dc06b0245a0530c2cf53e3f9c9e
https://doi.org/10.1158/1535-7163.c.6532214
https://doi.org/10.1158/1535-7163.c.6532214
Autor:
Paul Dent, Steven Grant, Adly Yacoub, Besim Ogretmen, Christina Voelkel-Johnson, Dieter Häussinger, Roland Reinehr, Margaret A. Park
Sorafenib and vorinostat interact in a synergistic fashion to kill carcinoma cells by activating CD95; the present studies have determined how sorafenib and vorinostat individually contribute to CD95 activation. Sorafenib (3–6 μmol/L) promoted a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d994c94022dfb0bce877e55fb45e514
https://doi.org/10.1158/1535-7163.c.6531942.v1
https://doi.org/10.1158/1535-7163.c.6531942.v1
Autor:
Paul Dent, Steven Grant, Besim Ogretmen, Christina Voelkel-Johnson, Paul B. Fisher, Sarah Spiegel, Andrew Larner, Roland Reinehr, Dieter Häussinger, Jeremy Allegood, Adly Yacoub, Guo Zhang, Clint Mitchell, Margaret A. Park
Supplementary Figures 1-8 from Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070662557e651c5eae2d8d2ce1ef3758
https://doi.org/10.1158/0008-5472.22381985.v1
https://doi.org/10.1158/0008-5472.22381985.v1
Autor:
Paul Dent, Steven Grant, Besim Ogretmen, Christina Voelkel-Johnson, Paul B. Fisher, Sarah Spiegel, Andrew Larner, Roland Reinehr, Dieter Häussinger, Jeremy Allegood, Adly Yacoub, Guo Zhang, Clint Mitchell, Margaret A. Park
The targeted therapeutics sorafenib and vorinostat interact in a synergistic fashion to kill carcinoma cells by activating CD95, and this drug combination is entering phase I evaluation. In this study, we determined how CD95 is activated by treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edb0c8b47c30cd914a0c9214f9a6fc80
https://doi.org/10.1158/0008-5472.c.6500057.v1
https://doi.org/10.1158/0008-5472.c.6500057.v1
Publikováno v:
Cellular Physiology and Biochemistry, Vol 36, Iss 3, Pp 866-883 (2015)
Background/Aims: Ursodeoxycholic acid, which in vivo is rapidly converted into its taurine conjugate, is frequently used for the treatment of cholestatic liver disease. Apart from its choleretic effects, tauroursodeoxycholate (TUDC) can protect hepat
Externí odkaz:
https://doaj.org/article/13cb487776b147049f76050d7478b78b
Autor:
Tabea A Mundinger, Annika Sommerfeld, Roland Reinehr, Joachim P Spatz, Dieter Häussinger, Heike Boehm
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48100 (2012)
Hepatocyte volume regulation has been shown to play an important role in cellular metabolism, proliferation, viability and especially in hepatic functions such as bile formation and proteolysis. Recent studies on liver explants led to the assumption
Externí odkaz:
https://doaj.org/article/1fbc59316af744c7b433d0b65656fce0
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 143:111-114
Zusammenfassung Anamnese Einige Wochen nach Antibiotikatherapie wird ein älterer Patient mit ausgeprägter Beeinträchtigung durch anhaltende Diarrhö eingeliefert. Untersuchungen Unter der Exsikkose hat sich eine Niereninsuffizienz verschlechtert,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c90f7b276809b6ba94c6da162f91de0
https://doi.org/10.1055/s-0043-122032
https://doi.org/10.1055/s-0043-122032
Publikováno v:
Deutsches Ärzteblatt international.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4c2eb96cd3561ec518c033355ac4e1
https://doi.org/10.3238/arztebl.2019.0221b
https://doi.org/10.3238/arztebl.2019.0221b