Zobrazeno 1 - 10
of 396
pro vyhledávání: '"Roland, Stocker"'
Autor:
James Nadel, Xiaoying Wang, Prakash Saha, André Bongers, Sergey Tumanov, Nicola Giannotti, Weiyu Chen, Niv Vidger, Mohammed Chowdhury, Gastao Lima Da Cruz, Carlos Velasco, PhD, Claudia Prieto, PhD, Andrew Jabbour, René Botnar, PhD, Roland Stocker, Alkystis Phinikaridou
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss , Pp 100842- (2024)
Externí odkaz:
https://doaj.org/article/c6fcc40620024e958b72a91de997e7c0
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106881- (2023)
Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit. Recently, a sample ex
Externí odkaz:
https://doaj.org/article/0562295b8e8f4165bbc10f13facc34a8
Autor:
Raphael F. Queiroz, Christopher P. Stanley, Kathryn Wolhuter, Stephanie M. Y. Kong, Ragul Rajivan, Naomi McKinnon, Giang T. H. Nguyen, Antonella Roveri, Sebastian Guttzeit, Philip Eaton, William A. Donald, Fulvio Ursini, Christine C. Winterbourn, Anita Ayer, Roland Stocker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
A major question in redox signaling is how H2O2 oxidizes target protein thiols in the presence of glutathione peroxidases and peroxiredoxins. We reveal signaling by H2O2 via its enzymatic conversion to an alkyl hydroperoxide that stereo-specifically
Externí odkaz:
https://doaj.org/article/16b1acb3e2684793a89d03d6d3dc92b4
Autor:
Hoi Yin Mak, Qian Ouyang, Sergey Tumanov, Jiesi Xu, Ping Rong, Feitong Dong, Sin Man Lam, Xiaowei Wang, Ivan Lukmantara, Ximing Du, Mingming Gao, Andrew J. Brown, Xin Gong, Guanghou Shui, Roland Stocker, Xun Huang, Shuai Chen, Hongyuan Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the synthesis of all glycerolipids. Here, the authors show that AGPAT2 and CDP-DAG synthases (CDS1 an
Externí odkaz:
https://doaj.org/article/f5314785099443818eeaa3ca9fffb125
Autor:
Weiyu Chen, Sergey Tumanov, Stephanie M.Y. Kong, David Cheng, Erik Michaëlsson, André Bongers, Carl Power, Anita Ayer, Roland Stocker
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102532- (2022)
Currently there are no established therapies to treat high-risk patients with unstable atherosclerotic lesions that are prone to rupture and can result in thrombosis, abrupt arterial occlusion, and a precipitous infarction. Rather than being stenotic
Externí odkaz:
https://doaj.org/article/e86c3169182c43f29ce87c8864fad5c7
Autor:
Weiyu Chen, Sergey Tumanov, Daniel J. Fazakerley, James Cantley, David E. James, Louise L. Dunn, Taqi Shaik, Cacang Suarna, Roland Stocker
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102152- (2021)
Background & aims: Plasma concentrations of bilirubin, a product of heme catabolism formed by biliverdin reductase A (BVRA), inversely associate with the risk of metabolic diseases including hepatic steatosis and diabetes mellitus in humans. Bilirubi
Externí odkaz:
https://doaj.org/article/41af8d9bb78949eebc861578f2f815f1
Autor:
Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY. Kong, Jelske N. van der Veen, Andrian Yang, Joshua W.K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, René L. Jacobs, Roland Stocker
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102127- (2021)
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a rang
Externí odkaz:
https://doaj.org/article/e5e37048d10e4f0db080cc6d7d4696a3
Autor:
Weiyu Chen, Sergey Tumanov, Christopher P. Stanley, Stephanie M.Y. Kong, James Nadel, Niv Vigder, Darren L. Newington, Xiao Suo Wang, Louise L. Dunn, Roland Stocker
Publikováno v:
Circulation Research. 132:812-827
Background: The rupture of atherosclerotic plaque contributes significantly to cardiovascular disease. Plasma concentrations of bilirubin—a byproduct of heme catabolism—inversely associate with risk of cardiovascular disease, although the link be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4087cacf2db7079142f1d78989963372
https://doi.org/10.1161/circresaha.122.322418
https://doi.org/10.1161/circresaha.122.322418
Autor:
Niv Vigder, Cacang Suarna, Leo Corcilius, James Nadel, Weiyu Chen, Richard Payne, Sergey Tumanov, Roland Stocker
Publikováno v:
Free Radical Biology and Medicine. 195:23-35
Conversion of the redox probe hydroethidine (HE) to 2-chloroethidium (2-Cl-E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9df233303435f6c190224ecc8663a48
https://doi.org/10.1016/j.freeradbiomed.2022.12.014
https://doi.org/10.1016/j.freeradbiomed.2022.12.014
Autor:
Giulia Bortolussi, Xiaoxia Shi, Lysbeth ten Bloemendaal, Bhaswati Banerjee, Dirk R. De Waart, Gabriele Baj, Weiyu Chen, Ronald P. Oude Elferink, Ulrich Beuers, Coen C. Paulusma, Roland Stocker, Andrés F. Muro, Piter J. Bosma
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 2029 (2021)
Accumulation of neurotoxic bilirubin due to a transient neonatal or persistent inherited deficiency of bilirubin glucuronidation activity can cause irreversible brain damage and death. Strategies to inhibit bilirubin production and prevent neurotoxic
Externí odkaz:
https://doaj.org/article/9e009047432a43d0942b9885748f455b