Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Roland, Brock"'
Autor:
Tjessa Bondue, Sante Princiero Berlingerio, Florian Siegerist, Elena Sendino-Garví, Maximilian Schindler, Hans Jacobus Baelde, Sara Cairoli, Bianca Maria Goffredo, Fanny Oliveira Arcolino, Jürgen Dieker, Manoe Jacoba Janssen, Nicole Endlich, Roland Brock, Rik Gijsbers, Lambertus van den Heuvel, Elena Levtchenko
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Messenger RNA (mRNA) therapies are emerging in different disease areas, but have not yet reached the kidney field. Our aim was to study the feasibility to treat the genetic defect in cystinosis using synthetic mRNA in cell models and ctns
Externí odkaz:
https://doaj.org/article/e4841b6ebf164c40bbddf71bdbfa5308
Autor:
Najoua El Boujnouni, M. Leontien van der Bent, Marieke Willemse, Peter A.C. ’t Hoen, Roland Brock, Derick G. Wansink
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 622-636 (2023)
Antisense oligonucleotide (ASO) therapies for myotonic dystrophy type 1 (DM1) are based on elimination of transcripts containing an expanded repeat or inhibition of sequestration of RNA-binding proteins. This activity is achievable by both degradatio
Externí odkaz:
https://doaj.org/article/97e890b2b5784324b32954702b47d821
Autor:
Daan C. ‘t Hart, Dilemin Yildiz, Valentina Palacio-Castañeda, Lanhui Li, Burcu Gumuscu, Roland Brock, Wouter P. R. Verdurmen, Johan van der Vlag, Tom Nijenhuis
Publikováno v:
Biosensors, Vol 13, Iss 3, p 339 (2023)
Crosstalk between glomerular endothelial cells and glomerular epithelial cells (podocytes) is increasingly becoming apparent as a crucial mechanism to maintain the integrity of the glomerular filtration barrier. However, in vitro studies directly inv
Externí odkaz:
https://doaj.org/article/58cfe91930f643149614662cc8ac93c8
Autor:
Lea Andrée, Rik Oude Egberink, Josephine Dodemont, Negar Hassani Besheli, Fang Yang, Roland Brock, Sander C. G. Leeuwenburgh
Publikováno v:
Nanomaterials, Vol 12, Iss 19, p 3423 (2022)
Messenger RNA (mRNA) is increasingly gaining interest as a modality in vaccination and protein replacement therapy. In regenerative medicine, the mRNA-mediated expression of growth factors has shown promising results. In contrast to protein delivery,
Externí odkaz:
https://doaj.org/article/54fba2e664f74e898b583ec537e3ab3f
Autor:
Rik Oude Egberink, Helen M. Zegelaar, Najoua El Boujnouni, Elly M. M. Versteeg, Willeke F. Daamen, Roland Brock
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1619 (2022)
In our aging society, the number of patients suffering from poorly healing bone defects increases. Bone morphogenetic proteins (BMPs) are used in the clinic to promote bone regeneration. However, poor control of BMP delivery and thus activity necessi
Externí odkaz:
https://doaj.org/article/4776628b3a35499e88b6d505f70f229a
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The molecular organization of the membrane of the red blood cell controls cell morphology and function and is thereby a main determinant of red blood cell homeostasis in the circulation. The role of membrane organization is prominently reflected in r
Externí odkaz:
https://doaj.org/article/2f141664a6154dd7acca9b056ee6ac29
Autor:
Lisanne M. P. E. van Oppen, Loai K. E. A. Abdelmohsen, Sjenet E. van Emst-de Vries, Pascal L. W. Welzen, Daniela A. Wilson, Jan A. M. Smeitink, Werner J. H. Koopman, Roland Brock, Peter H. G. M. Willems, David S. Williams, Jan C.M. van Hest
Publikováno v:
ACS Central Science, Vol 4, Iss 7, Pp 917-928 (2018)
Externí odkaz:
https://doaj.org/article/2277ffd6f92a4412b7d22285f7c0bf54
Autor:
Valentina Palacio-Castañeda, Rik Oude Egberink, Arbaaz Sait, Lea Andrée, Benedetta Maria Sala, Negar Hassani Besheli, Egbert Oosterwijk, Johan Nilvebrant, Sander C. G. Leeuwenburgh, Roland Brock, Wouter P. R. Verdurmen
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1944 (2021)
To investigate the delivery of next-generation macromolecular drugs, such as engineered proteins and mRNA-containing nanoparticles, there is an increasing push towards the use of physiologically relevant disease models that incorporate human cells an
Externí odkaz:
https://doaj.org/article/842f0bdef5604d1ea314bb50f5788322
Autor:
Estel Collado Camps, Sanne A. M. van Lith, Cathelijne Frielink, Jordi Lankhof, Ingrid Dijkgraaf, Martin Gotthardt, Roland Brock
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 602 (2021)
Nanobodies are well-established targeting ligands for molecular imaging and therapy. Their short circulation time enables early imaging and reduces systemic radiation exposure. However, shorter circulation time leads to lower tracer accumulation in t
Externí odkaz:
https://doaj.org/article/235ccdf9b5634ec0b396c5a48b6470c7
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
A subset of the red blood cells (RBCs) of patients with paroxysmal nocturnal hemoglobinuria (PNH) lacks GPI-anchored proteins. Some of these proteins, such as CD59, inhibit complement activation and protect against complement-mediated lysis. This pat
Externí odkaz:
https://doaj.org/article/1e93cb23ef834351bbb6bddbd0371459