Výsledky vyhledávání - "Rola, Al Sayegh"

Akademický článek

MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

Autor: Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Liver cirrhosis is characterised by extensive fibrosis of the liver, and understanding the underpinning immunological processes is important in designing intervention. Here authors show that Mucosal-Associated Invariant T cells are instrumental to co

Externí odkaz: https://doaj.org/article/49d8dca78ad94f9fac7e66da26a40cc1

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Akademický článek

Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration

Autor: Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz

Publikováno v: JHEP Reports, Vol 5, Iss 8, Pp 100794- (2023)

Background & Aims: Liver regeneration is a repair process in which metabolic reprogramming of parenchymal and inflammatory cells plays a major role. Monoacylglycerol lipase (MAGL) is an ubiquitous enzyme at the crossroad between lipid metabolism and

Externí odkaz: https://doaj.org/article/346571883a5f4eb1b52cd8a45a9591b1

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Akademický článek

Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris

Autor: Aneese A. Jaffa, Miran A. Jaffa, Mayssam Moussa, Ibrahim A. Ahmed, Mia Karam, Kawthar Sharaf Aldeen, Rola Al Sayegh, Ghewa A. El-Achkar, Leila Nasrallah, Yara Yehya, Aida Habib, Fuad N. Ziyadeh, Ali H. Eid, Firas H. Kobeissy, Ayad A. Jaffa

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, microglia promote the

Externí odkaz: https://doaj.org/article/8dd264650da5460bb2dfd713f8d2f363

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Akademický článek

Plasma Kallikrein as a Modulator of Liver Injury/Remodeling

Autor: Ibrahim A Ahmed, Miran A Jaffa, Mayssam Moussa, Duaa Hatem, Ghewa A El-Achkar, Rola Al Sayegh, Mia Karam, Eva Hamade, Aida Habib, Ayad A Jaffa

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The occurrence and persistence of hepatic injury which arises from cell death and inflammation result in liver disease. The processes that lead to liver injury progression and resolution are still not fully delineated. The plasma kallikrein-kinin sys

Externí odkaz: https://doaj.org/article/4deb9a8e9ad54fe7a774b83a0215e5c3

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