Zobrazeno 1 - 4
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pro vyhledávání: '"Roketa S. Sloan"'
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005098 (2015)
Topoisomerase 1 (Top1), a Type IB topoisomerase, functions to relieve transcription- and replication-associated torsional stress in DNA. We investigated the effects of Top1 on genome stability in Saccharomyces cerevisiae using two different assays. F
Externí odkaz:
https://doaj.org/article/17f23bbbec0c4b55942d65b12302244e
Topoisomerase I (Top1) removes DNA torsional stress by nicking and resealing one strand of DNA, and is essential in higher eukaryotes. The enzyme is frequently overproduced in tumors and is the sole target of the chemotherapeutic drug camptothecin (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf88f27a0380f4afa72ea2d6393d2dc0
https://europepmc.org/articles/PMC5691608/
https://europepmc.org/articles/PMC5691608/
Autor:
Kristen N. Smith, Roketa S. Sloan, Robert J. Duronio, Lily Gavilano, Pamela Y. Malek, S. Catherine Silver Key, Christina I. Swanson, Mayronne Snow-Smith
Publikováno v:
Fly. 6:173-183
The Drosophila lethal(2)denticleless (l(2)dtl) gene was originally reported as essential for embryogenesis and formation of the rows of tiny hairs on the larval ventral cuticle known as denticle belts. It is now well-established that l(2)dtl (also ca
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 11, Iss 4, p e1005098 (2015)
PLoS Genetics, Vol 11, Iss 4, p e1005098 (2015)
Topoisomerase 1 (Top1), a Type IB topoisomerase, functions to relieve transcription- and replication-associated torsional stress in DNA. We investigated the effects of Top1 on genome stability in Saccharomyces cerevisiae using two different assays. F