Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Rok Humar"'
Autor:
Kevin Akeret, Raphael M. Buzzi, Moritz Saxenhofer, Kathrin Bieri, Deborah Chiavi, Bart R. Thomson, Manuela Grüttner-Durmaz, Nina Schwendinger, Rok Humar, Luca Regli, Tristan P. C. van Doormaal, Ulrike Held, Emanuela Keller, Michael Hugelshofer, Dominik J. Schaer, HeMoVal Research Group
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Introduction Preclinical studies provided a strong rationale for a pathophysiological link between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain injury after subarachnoid hemorrhage (SAH-SBI). In a single-cente
Externí odkaz:
https://doaj.org/article/8890151b835a49248d1e5823702943eb
Autor:
Marc Pfefferlé, Giada Ingoglia, Christian A. Schaer, Kerstin Hansen, Nadja Schulthess, Rok Humar, Dominik J. Schaer, Florence Vallelian
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Clearance of red blood cells and hemoproteins is a key metabolic function of macrophages during hemolytic disorders and following tissue injury. Through this archetypical phagocytic function, heme is detoxified and iron is recycled to support erythro
Externí odkaz:
https://doaj.org/article/00b7cb1271094c5eb1a0b54b1f16ed2e
Autor:
Ayla Yalamanoglu, Irina L. Dubach, Nadja Schulthess, Giada Ingoglia, Delaney C. Swindle, Rok Humar, Dominik J. Schaer, Paul W. Buehler, David C. Irwin, Florence Vallelian
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sickle cell disease (SCD) is an inherited hemolytic disorder, defined by a point mutation in the β-globin gene. Stress conditions such as infection, inflammation, dehydration, and hypoxia trigger erythrocyte sickling. Sickled red blood cells (RBCs)
Externí odkaz:
https://doaj.org/article/58bf6bf84737489ab9450d5c0f2be0db
Autor:
Ian Galea, Soham Bandyopadhyay, Diederik Bulters, Rok Humar, Michael Hugelshofer, Dominik J. Schaer, Amr Abdulazim, Andrew F. Alalade, Sheila A. Alexander, Sergi Amaro, Sepideh Amin-Hanjani, Christopher R. Andersen, Craig Anderson, Matthew H. Anstey, József Balla, Nourou Dine Adeniran Bankole, Judith Bellapart, Hemant Bhagat, Spiros L. Blackburn, Markus Brechmann, Paul W. Buehler, Jan-Karl Burkhardt, Yujie Chen, Jeremy Cohen, P. David Cooper, Liam G. Coulthard, Elisa Cuadrado-Godia, Joan Dalton, Anthony Delaney, Sylvain Doré, Jonathan Downer, Justin Dye, Isabel Fernandez-Perez, Oliver Flower, Béla Fülesdi, Ben Gaastra, Thomas Gaberel, James Galea, Gbetoho Fortuné Gankpe, Patrick Garland, Thomas Gentinetta, Magnus Gram, Jonas Heilskov Graversen, Patrick J. Grover, Daniel Guisado-Alonso, David Hasan, Adel Helmy, Julius Höhne, Isabel Charlotte Hostettler, Ajay Prasad Hrishi, Koji Iihara, David C. Irwin, Kiran Jangra, Aruma Jiménez-O’Shanahan, Richard F. Keep, Matthew Koch, Miikka Korja, Munish Kumar, Laura Llull, James JM Loan, Miguel Ángel Lopez-Gonzalez, R. Loch Macdonald, Shalvi Mahajan, Joan Martí-Fàbregas, Jose Medina-Suárez, Soren Moestrup, John More, Eghosa Morgan, Radhakrishnan Muthuchellappan, Paul Nyquist, Coralia Sosa Pérez, Promod Pillai, Nikolaus Plesnila, Jose Javier Provencio, Eamon Raith, Anna Ramos-Pachón, Scott B. Raymond, Luca Regli, Ynte Marije Ruigrok, Poonam Saharan, Edgar A. Samaniego, Gerrit Alexander Schubert, Ian Seppelt, Kamath Sriganesh, Jose I. Suarez, Jonathon Taylor, Nicole A. Terpolilli, Fernando D. Testai, Emanuela Tolosano, Ahmed K. Toma, Anderson Chun On Tsang, Andrew A. Udy, Florence Vallelian, Mariana Vargas-Caballero, Gregory M Vercellotti, Mervyn D.I. Vergouwen, Michaela Waak, Hannah Warming, Peter C. Whitfield, George Kwok-chu Wong, Jason Wright, Adrian W. Zuercher
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating form of stroke frequently affecting young to middle-aged adults, with an unmet need to improve outcome. This special report focusses on the development of intrathecal haptoglobin supplementat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a25129170eddadbded8b4eb4222689
Autor:
Dominik J. Schaer, M. Seboek, Jeremy W. Deuel, B. Thomson, Rok Humar, Emanuela Keller, Jan Willms, Christian A. Schaer, Florence Vallelian, Raphael M Buzzi, Ulrike Held, Luca Regli, Michael Hugelshofer, Sophie S. Wang, Kevin Akeret
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Brain and Spine, Vol 1, Iss, Pp 100310-(2021)
Brain and Spine, Vol 1, Iss, Pp 100310-(2021)
Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) is a significant contributor to poor outcomes in patients after rupture of an intracranial aneurysm. The lack of diagnostic biomarkers and novel drug targets represent an unmet
Autor:
Kevin, Akeret, Raphael M, Buzzi, Moritz, Saxenhofer, Kathrin, Bieri, Deborah, Chiavi, Bart R, Thomson, Manuela, Grüttner-Durmaz, Nina, Schwendinger, Rok, Humar, Luca, Regli, Tristan P C, van Doormaal, Ulrike, Held, Emanuela, Keller, Michael, Hugelshofer, Dominik J, Schaer, Vincens, Kälin
Publikováno v:
Akeret, Kevin; Buzzi, Raphael M; Saxenhofer, Moritz; Bieri, Kathrin; Chiavi, Deborah; Thomson, Bart R; Grüttner-Durmaz, Manuela; Schwendinger, Nina; Humar, Rok; Regli, Luca; van Doormaal, Tristan P C; Held, Ulrike; Keller, Emanuela; Hugelshofer, Michael; Schaer, Dominik J (2022). The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury. BMC neurology, 22(1), p. 267. BioMed Central 10.1186/s12883-022-02789-w
Introduction Preclinical studies provided a strong rationale for a pathophysiological link between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain injury after subarachnoid hemorrhage (SAH-SBI). In a single-center prospec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ce927eaf4cacffbc1a6c9f65b7d997
https://boris.unibe.ch/171617/1/Akeret_BMCNeurol_2022.pdf
https://boris.unibe.ch/171617/1/Akeret_BMCNeurol_2022.pdf
Autor:
Dominik J. Schaer, Andreas Wassmer, Ayla Yalamanoglu, Raphael M Buzzi, Marc Pfefferlé, Rok Humar, Nadja Schulthess, Florence Vallelian, Thomas Gentinetta, Kerstin Hansen
Heme is an erythrocyte-derived toxin that drives disease progression in hemolytic anemias, such as sickle cell disease. During hemolysis, specialized bone marrow-derived macrophages with a high heme-metabolism capacity orchestrate disease adaptation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d60e0cd57c6f073e30aa062137ba26b4
https://doi.org/10.1101/2021.07.29.454342
https://doi.org/10.1101/2021.07.29.454342
Publikováno v:
Forum Médical Suisse ‒ Swiss Medical Forum.
Publikováno v:
Swiss Medical Forum ‒ Schweizerisches Medizin-Forum.
Autor:
Rok Humar, Nadja Schulthess, Kerstin Hansen, Marc Pfefferlé, Christian A. Schaer, Giada Ingoglia, Dominik J. Schaer, Florence Vallelian
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Clearance of red blood cells and hemoproteins is a key metabolic function of macrophages during hemolytic disorders and following tissue injury. Through this archetypical phagocytic function, heme is detoxified and iron is recycled to support erythro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f12052634bc18fddb4649ff7c42a64d
https://doi.org/10.5167/uzh-204819
https://doi.org/10.5167/uzh-204819