Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Rok Grahek"'
Publikováno v:
Journal of Pharmaceutical Sciences. 112:1277-1286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::936e1b53a35ddec878081a9724749aa5
https://doi.org/10.1016/j.xphs.2023.03.007
https://doi.org/10.1016/j.xphs.2023.03.007
Publikováno v:
Acta Pharmaceutica, Vol 69, Iss 3, Pp 363-380 (2019)
Acta Pharmaceutica
Volume 69
Issue 3
Acta Pharmaceutica
Volume 69
Issue 3
An ultra-high performance liquid chromatography method for simultaneous determination of tacrolimus impurities in pharmaceutical dosage forms has been developed. Appropriate chromatographic separation was achieved on a BEH C18 column using gradient e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715fbf278fd8b9440275ed5ab859cb82
https://doaj.org/article/54ec73a7ee72486f86dd35defad533fe
https://doaj.org/article/54ec73a7ee72486f86dd35defad533fe
Publikováno v:
International Journal of Pharmaceutics. 618:121687
The recent focus of pharmaceutical regulatory authorities has been oriented towards the mitigation of carcinogenic N-nitrosamines in drug products and different sources of N-nitrosamines have been revealed. Within this work, the elucidation of a furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b7de16d2782222474f3a0625da6160
https://doi.org/10.1016/j.ijpharm.2022.121687
https://doi.org/10.1016/j.ijpharm.2022.121687
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 110:67-75
Tacrolimus is macrolide drug that is widely used as a potent immunosuppressant. In the present work compatibility testing was conducted on physical mixtures of tacrolimus with excipients and on compatibility mixtures prepared by the simulation of man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e6fc963bb446891b1bcb9919ccef5b
https://doi.org/10.1016/j.jpba.2015.02.047
https://doi.org/10.1016/j.jpba.2015.02.047
Autor:
Lucija Zupančič-Kralj, Rok Grahek
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 50:1037-1043
An HPLC/MS/MS method was developed for identification of impurities in gentamicin. The HPLC was performed on a Synergy Hydro-RP column using 50 mM trifluoroacetic acid (TFA), pH 2 adjusted with ammonium solution and methanol as mobile phase. All impu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1eed92ed0c1705a06b7e23f69204d4c
https://doi.org/10.1016/j.jpba.2009.06.004
https://doi.org/10.1016/j.jpba.2009.06.004
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 50:729-736
Methods were developed for the preparation and isolation of four oxidative degradation products of atorvastatin. ATV-FX1 was prepared in the alkaline acetonitrile solution of atorvastatin with the addition of hydrogen peroxide. The exposition of aque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9c3e991f578c2baead5ec8801bc678
https://doi.org/10.1016/j.jpba.2009.06.008
https://doi.org/10.1016/j.jpba.2009.06.008
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 755:229-235
The chromatographic behaviour of the ACE inhibitors lisinopril, enalapril and its two degradation products, enalaprilat (hydrolytic degradation product) and diketopiperazine (DKP) (cyclization degradation product) was studied as a function of column
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc450c898bea79fa7989e9d444751f8
https://doi.org/10.1016/s0378-4347(01)00082-2
https://doi.org/10.1016/s0378-4347(01)00082-2
Autor:
Vladimir Kotnik, Slavko Pečar, Danijel Kikelj, Branka Wraber-Herzog, Renate Rogi-Kohlenprath, Alojz Ihan, Helmut Hönig, Rok Grahek, Anton Stalc, Saša Simčič, Mirjam Hočevar, Lucka Povsic, Elizabeta Suhadolc, Lidija Mag. Klamfer
Publikováno v:
Journal of Medicinal Chemistry. 41:530-539
A novel non-pyrogenic carbocyclic muramyl dipeptide (MDP) analogue, N-¿trans-2-[[2'-(acetylamino)cyclohexyl]oxy]acetyl¿-L-alanyl-D-glutamic acid, was obtained by replacement of the N-acetylmuramic acid part and the D-isoglutamine residue of the MDP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90d37dd4f11cbbebcd95b75c4dbb524
https://doi.org/10.1021/jm970509d
https://doi.org/10.1021/jm970509d
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 822(1-2)
High throughput methods (high performance liquid chromatography and capillary electrophoresis) were developed to determine pravastatin in production media. The analyses were performed on particle column, monolithic column and silica capillary filled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5707374fa10a26483c9d370ac4d22838
https://pubmed.ncbi.nlm.nih.gov/15990369
https://pubmed.ncbi.nlm.nih.gov/15990369
Publikováno v:
The Journal of organic chemistry. 68(8)
The enantiomeric resolution and the elution order of (+/-)-trans-7,8-dihydrodiols of benzo[a]pyrene and its 6-fluoro and 6-bromo derivatives were analyzed on three polysaccharide-based columns: Daicel Chiralcel CA-I (cellulose triacetate), OF, and OG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56289017a7018eabc60b94b3f7ae466
https://pubmed.ncbi.nlm.nih.gov/12688804
https://pubmed.ncbi.nlm.nih.gov/12688804