Výsledky vyhledávání

Dissertation/ Thesis

Characterization of Fat-Storing Cell Lines Derived From Normal and CCl4-Cirrhotic Livers. Differences in the Production of Interleukin-6

Autor: Greenwel, P., Schwartz, M., Rosas, M., Peyrol, S., Grimaud, J. A., Rojkind, M.

Publikováno v: ETSU Faculty Works.

Liver fat-storing cells (FSC) play an important role in collagen deposition. During the induction of liver cirrhosis, FSC lose their fat droplets, acquire an actin-rich cytoskeleton and transform into myofibroblasts. Myofibroblasts have been associat

Externí odkaz: https://dc.etsu.edu/etsu-works/10938
https://pubmed.ncbi.nlm.nih.gov/1753710/

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A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury

Autor: Ezquerro, I.J. (Ignacio José), Lasarte, J.J. (Juan José), Dotor, J. (Javier), Castilla-Cortazar, I. (Inma), Bustos, M. (Matilde), Peñuelas-Sanchez, I. (Ivan), Blanco, G. (Gemma), Rodriguez-Ortigosa, C.M. (Carlos M.), Lechuga, M.C.G. (María del Carmen G.), Greenwel, P. (Patricia), Rojkind, M. (Marcos), Prieto, J. (Jesús), Borras-Cuesta, F. (Francisco)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Transforming growth factor beta1 (TGF-beta1) is a pleiotropic cytokine, which displays potent profibrogenic effects and is highly expressed in fibrotic livers. For this reason, development of TGF-B1 inhibitors might be of great importance to control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::26465d1760d5292c6f1de380b2b1308f
https://hdl.handle.net/10171/21673

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Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts

Autor: Rombouts, Krista, Niki, T., Greenwel, P., Vandermonde, Alain, Wielant, Annemie, Hellemans, Karine, De Bleser, Pieter, Yoshida, A.m., Schuppan, D., Rojkind, M., Geerts, Albert

Excessive production of collagens by alpha-smooth muscle actin (alpha-SMA)-positive myofibroblasts leads to fibrotic skin diseases, such as hypertrophic scarring. This process is characterized by an imbalance between extracellular matrix (ECM) synthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3848::5e6a00a85b4baf037279f75ee8c460e3
https://biblio.vub.ac.be/vubir/trichostatin-a-a-histone-deacetylase-inhibitor-suppresses-collagen-synthesis-and-prevents-tgfbeta1induced-fibrogenesis-in-skin-fibroblasts(e01c36b7-4f6b-433d-8854-445b339d10e1).html

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