Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Rojina, Ranjit"'
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1582-1596 (2021)
Abstract Background Oxidative stress and damage are associated with a number of ageing phenotypes, including age‐related loss of muscle mass and reduced contractile function (sarcopenia). Our group and others have reported loss of neuromuscular jun
Externí odkaz:
https://doaj.org/article/9bac5f8dec0d46829cc8a059124a8aef
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 1, Pp 75-89 (2021)
Abstract Background Mitochondrial bioenergetics are sensitive to adenosine diphosphate (ADP) concentration. Reactive oxygen species (ROS) production and respiration [oxygen consumption rate (OCR)] are altered at physiological ADP concentrations (i.e.
Externí odkaz:
https://doaj.org/article/c9d73ee999be4822bd37c746dcd9070e
Autor:
Hongyang Xu, Shylesh Bhaskaran, Katarzyna M. Piekarz, Rojina Ranjit, Jan Bian, Parker Kneis, Aubrey Ellis, Suyesha Bhandari, Heather C. Rice, Holly Van Remmen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Emerging evidence suggests that patients with Alzheimer’s disease (AD) may show accelerated sarcopenia phenotypes. To investigate whether pathological changes associated with neuronal death and cognitive dysfunction also occur in peripheral motor n
Externí odkaz:
https://doaj.org/article/33029d926d524910bcfb714ac428edef
Publikováno v:
Antioxidants, Vol 11, Iss 12, p 2358 (2022)
Sarcopenia, the progressive loss of muscle mass and dysfunction, universally affects the elderly and is closely associated with frailty and reduced quality of life. Despite the inevitable consequences of sarcopenia and its relevance to healthspan, no
Externí odkaz:
https://doaj.org/article/29dc82c85c30428f8e5fd2a0cf84cac2
Autor:
Bumsoo Ahn, Rojina Ranjit, Pavithra Premkumar, Gavin Pharaoh, Katarzyna M. Piekarz, Satoshi Matsuzaki, Dennis R. Claflin, Kaitlyn Riddle, Jennifer Judge, Shylesh Bhaskaran, Kavithalakshmi Satara Natarajan, Erika Barboza, Benjamin Wronowski, Michael Kinter, Kenneth M. Humphries, Timothy M. Griffin, Willard M. Freeman, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 411-428 (2019)
Abstract Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology an
Externí odkaz:
https://doaj.org/article/bf068644f5f343948ea2be767d068283
Autor:
Rizwan Qaisar, Shylesh Bhaskaran, Rojina Ranjit, Kavithalakshmi Sataranatarajan, Pavithra Premkumar, Kendra Huseman, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 68-74 (2019)
Molecular targets to reduce muscle weakness and atrophy due to oxidative stress have been elusive. Here we show that activation of Sarcoplasmic Reticulum (SR) Ca2+ ATPase (SERCA) with CDN1163, a novel small molecule allosteric SERCA activator, amelio
Externí odkaz:
https://doaj.org/article/1109ff0a1f05410a8f10d187f34502b4
Autor:
Roshini Sathiaseelan, Bumsoo Ahn, Michael B Stout, Sreemathi Logan, Jonathan Wanagat, Hoang Van M Nguyen, Norman G Hord, Amy R Vandiver, Ramasamy Selvarani, Rojina Ranjit, Hannah Yarbrough, Anthony Masingale, Benjamin F Miller, Roman F Wolf, Steven N Austad, Arlan Richardson
Publikováno v:
The Journals of Gerontology: Series A. 78:771-779
We generated a genetically heterogenous rat model by a 4-way cross strategy using 4 inbred strains (Brown Norway [BN], Fischer 344 [F344], Lewis [LEW], and Wistar Kyoto [KY]) to provide investigators with a highly genetically diverse rat model from c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d14d314dbf4c37472b4b446932ebdc9
https://doi.org/10.1093/gerona/glad056
https://doi.org/10.1093/gerona/glad056
Autor:
Rizwan Qaisar, Shylesh Bhaskaran, Pavithra Premkumar, Rojina Ranjit, Kavithalakshmi Satara Natarajan, Bumsoo Ahn, Kaitlyn Riddle, Dennis R. Claflin, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 5, Pp 1003-1017 (2018)
Abstract Background We have previously shown that the deletion of the superoxide scavenger, CuZn superoxide dismutase, in mice (Sod1−/− mice) results in increased oxidative stress and an accelerated loss of skeletal muscle mass and force that mir
Externí odkaz:
https://doaj.org/article/1ad724d6e92545639f0dae9a584dc46b
Autor:
Bumsoo Ahn, Nataliya Smith, Debra Saunders, Rojina Ranjit, Parker Kneis, Rheal A. Towner, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Mitochondrial dysfunction, reactive oxygen species (ROS) and oxidative damage have been implicated to play a causative role in age-related skeletal muscle atrophy and weakness (i.e. sarcopenia). Mice lacking the superoxide scavenger CuZnSOD (Sod1−/
Externí odkaz:
https://doaj.org/article/2438b08b2bb84681bebc429a667b350b
Autor:
Sreemathi Logan, Matthew P Baier, Daniel B Owen, John Peasari, Kenneth L Jones, Rojina Ranjit, Hannah P Yarbrough, Anthony M Masingale, Suyesha Bhandari, Heather C Rice, Michael T Kinter, William E Sonntag
Publikováno v:
PNAS Nexus. 2
The greatest risk factor for cognitive decline is aging. The biological mechanisms for this decline remain enigmatic due, in part, to the confounding of normal aging mechanisms and those that contribute to cognitive impairment. Importantly, many indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b17b8e3126b5e758046e96aada549a71
https://doi.org/10.1093/pnasnexus/pgad101
https://doi.org/10.1093/pnasnexus/pgad101