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The Pseudomonas aeruginosa antimetabolite L -2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor.

Autor: Rojas Murcia N; Department of Fundamental Microbiology, University of Lausanne, Lausanne Switzerland., Lee X; Department of Fundamental Microbiology, University of Lausanne, Lausanne Switzerland., Waridel P; Protein Analysis Facility, University of Lausanne, Lausanne Switzerland., Maspoli A; Department of Fundamental Microbiology, University of Lausanne, Lausanne Switzerland., Imker HJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA USA., Chai T; Department of Fundamental Microbiology, University of Lausanne, Lausanne Switzerland., Walsh CT; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA USA., Reimmann C; Department of Fundamental Microbiology, University of Lausanne, Lausanne Switzerland.

Publikováno v: Frontiers in microbiology [Front Microbiol] 2015 Mar 12; Vol. 6, pp. 170. Date of Electronic Publication: 2015 Mar 12 (Print Publication: 2015).