Glutamine metabolism is essential for coronavirus replication in host cells and in mice

Autor: Greene, Kai Su ^{1, ‡}, Choi, Annette ^{2, ‡}, Yang, Nianhui ¹, Chen, Matthew ¹, Li, Ruizhi ¹, Qiu, Yijian ³, Ezzatpour, Shahrzad ², Rojas, Katherine S. ¹, Shen, Jonathan ¹, Wilson, Kristin F. ¹, Katt, William P. ¹, Aguilar, Hector C. ², Lukey, Michael J. ³, Whittaker, Gary R. ^{2, 4}, Cerione, Richard A. ^{1, 5, ∗}

Publikováno v: In Journal of Biological Chemistry January 2025 301(1)

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Glutamine metabolism is essential for coronavirus replication in host cells and in mice.

Autor: Greene KS; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA., Choi A; Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA., Yang N; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA., Chen M; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA., Li R; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA., Qiu Y; Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA., Ezzatpour S; Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA., Rojas KS; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA., Shen J; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA., Wilson KF; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA., Katt WP; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA., Aguilar HC; Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA., Lukey MJ; Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA., Whittaker GR; Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA; Public & Ecosystem Health, Cornell University, Ithaca, New York, USA., Cerione RA; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA. Electronic address: rac1@cornell.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Dec 09; Vol. 301 (1), pp. 108063. Date of Electronic Publication: 2024 Dec 09.

Inhibiting Glutamine Metabolism Blocks Coronavirus Replication in Mammalian Cells.

Autor: Greene KS, Choi A, Chen M, Yang N, Li R, Qiu Y, Lukey MJ, Rojas KS, Shen J, Wilson KF, Katt WP, Whittaker GR, Cerione RA

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 28. Date of Electronic Publication: 2023 Sep 28.