Second Generation Synthesis of Modified Dinucleotide Analogues Featuring a Difluorophosphin(othio)yl Linkage.

Autor: Roignant, Matthieu¹ (AUTHOR), Zhang, Jun¹ (AUTHOR), Brioche, Julien¹ (AUTHOR), Piettre, Serge R.¹ (AUTHOR) serge.piettre@univ-rouen.fr

Publikováno v: European Journal of Organic Chemistry. 7/7/2022, Vol. 2022 Issue 25, p1-10. 10p.

Nouvelles stratégies synthétiques vers la formation d'hétérodinucléotides incorporant un motif difluorophosphinothioate

Autor: Roignant, Matthieu

Publikováno v: Chimie organique. Normandie Université, 2019. Français. ⟨NNT : 2019NORMR090⟩

Oligonucleotides (ONs) represent a major class of bioactive molecules with a great potential in medicinal chemistry. However, the development of therapeutic ONs is facing two major problems: a lack of stability toward nucleases and a lack of selectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b3266ec69d69449e5b14ac1eaff0a1e1
https://tel.archives-ouvertes.fr/tel-03494312/document

Synthesis of Fluorinated Modified Dinucleotide

Autor: Roignant, Matthieu, Brioche, Julien, Piettre, Serge

Publikováno v: Journée de l'Ecole doctorale normande de chimie (JEDNC, 2018)
Journée de l'Ecole doctorale normande de chimie (JEDNC, 2018), Jun 2018, Le Havre, France

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4612971df25a0eccfebd2394bca4c951
https://hal-normandie-univ.archives-ouvertes.fr/hal-02541572

Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

Autor: Hermant, Paul, Bosc, Damien, Piveteau, Catherine, Gealageas, Ronan, Lam, BaoVy, Ronco, Cyril, Roignant, Matthieu, Tolojanahary, Hasina, Jean, Ludovic, Renard, Pierre-Yves, Lemdani, Mohamed, Bourotte, Marilyne, Herledan, Adrien, Bedart, Corentin, Biela, Alexandre, Leroux, Florence, Deprez, Benoit, Deprez-Poulain, Rebecca

Publikováno v: Journal of Medicinal Chemistry; 20240101, Issue: Preprints