Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Roi Mashiach"'
Publikováno v:
Journal of Neuroimmunology. 302:41-48
Targeting Polymerase-1 (POL1) transcription machinery is a new strategy for suppression of multiple sclerosis (MS) disease activity that is based on suppression of ribosomal biogenesis and subsequent activation of apoptosis. We developed an oral POL1
Autor:
Orna Ernst, Muhammad Athamna, Michael M. Meijler, Roi Mashiach, Raju Adepu, Tsaffrir Zor, Rambabu Dandela, Rachel Gregor, Efrat Zecharia
Publikováno v:
Chemical communications (Cambridge, England). 53(27)
Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. We have developed an efficient synthesis of PCERA-1 from readil
Autor:
Liat Gindes, Roi Mashiach, Reuven Achiron, Yinon Gilboa, Jigal Haas, Mordechai Dulitski, Itai Gat, Alina Weissmann-Brenner, Eran Barzilay
Publikováno v:
Journal of Ultrasound in Medicine. 32:587-592
OBJECTIVES The purpose of this study was to examine the uterine cavity within 48 hours of delivery using 2- and 3-dimensional sonography after normal vaginal deliveries, instrumental deliveries, exploration of the uterine cavity, and cesarean deliver
Autor:
Neri Amara, Roi Mashiach, Dotan Amar, Pnina Krief, Stéphane A. H. Spieser, Matthew J. Bottomley, Amir Aharoni, Michael M. Meijler
Publikováno v:
Journal of the American Chemical Society. 131:10610-10619
Chemical coordination of gene expression among bacteria as a function of population density is regulated by a mechanism known as 'quorum sensing' (QS). QS in Pseudomonas aeruginosa, an opportunistic pathogen that causes disease in immunocompromised p
Autor:
Tsaffrir Zor, Galit Levy-Rimler, Orna Ernst, Maya Levi, Bill Webb, Meir Goldsmith, Nathanael S. Gray, Dorit Avni, Hugh Rosen, Roi Mashiach, Michael M. Meijler
Publikováno v:
Immunology. 127:103-115
Tight regulation of the production of the key pro-inflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) is essential for the prevention of chronic inflammatory diseases. In vivo administration of a synthetic phospholipid, named hereafter pho
Publikováno v:
Journal of Neuroimmunology
Applying high throughput gene expression microarrays we identified that the suppression of polymerase 1 (POL1) pathway is associated with benign course of multiple sclerosis (MS). This finding supports the rationale for direct targeting of the POL1 t
Autor:
Roi Mashiach, Michael M. Meijler
Publikováno v:
Organic Letters
Pyoverdin D is an important siderophore that is used by the human pathogen Pseudomonas aeruginosa to import iron and gain a competitive advantage. This unique partially cyclic octapeptide bears four nonproteinogenic amino acids, including (δ)N-formy
Autor:
Ala Daka, Tsaffrir Zor, Yifat Glucksam, Nadia F. Lamour, Meir Goldsmith, Michael M. Meijler, Charles E. Chalfant, Roi Mashiach
Publikováno v:
Immunology letters. 135(1-2)
Prostaglandin E 2 (PGE 2 ) is an important mediator of the inflammatory response. Phospho-ceramide analogue-1 (PCERA-1), a synthetic phospholipid-like molecule, was previously reported to modulate pro- and anti-inflammatory cytokine production. We sh
Autor:
Michael M. Meijler, Dorit Avni, Roi Mashiach, Tove Tuntland, Hugh Rosen, Tsaffrir Zor, Meir Goldsmith, Orna Ernst, Nathanael S. Gray
Publikováno v:
Immunology letters. 123(1)
Phospho-ceramide analog-1 (PCERA-1) has been described as a potent in vivo suppressor of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha), and thus as a putative drug for the treatment of inflammatory diseases. However, the in viv
Autor:
Ruth Gold-Deutch, Zvi Halperin, Negri M, Roi Mashiach, Mariana Ferszt, Ariel Halevy, Guy Lin, Jonathan Sackier, Ida Boldur
Publikováno v:
The American Journal of Surgery. 172:272-274
Objectives To assess the rate of infected bile in patients undergoing laparoscopic cholecystectomy (LC) and to study the influence on the postoperative infective complications in this group of patients. Methods Bile samples of 247 patients undergoing