Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Roi Gazit"'
Autor:
Fang Wu, Natali H. Muskat, Inbar Dvilansky, Omri Koren, Anat Shahar, Roi Gazit, Natalie Elia, Eyal Arbely
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Lysine acetylation has been discovered in thousands of non-histone human proteins, including most metabolic enzymes. Deciphering the functions of acetylation is key to understanding how metabolic cues mediate metabolic enzyme regulation and
Externí odkaz:
https://doaj.org/article/5a9cc0aa172d447a9f9aea9739c0cf0e
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Adult hematopoietic stem cells (HSCs) in the bone marrow (BM) are quiescent. Following perturbations, such as blood loss or infection, HSCs may undergo activation. Surprisingly, little is known about the earliest stages of HSCs activation. W
Externí odkaz:
https://doaj.org/article/6245967585cc4582854220be55eea2b7
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Most human genes code for more than one transcript. Different ratios of transcripts of the same gene can be found in different cell types or states, indicating differential use of transcription start sites or differential splicing. Such differential
Externí odkaz:
https://doaj.org/article/a3f3863c3c25450e9f279455ce65ba0c
Autor:
Omri Sharabi, Yariv Greenshpan, Noa Ofir, Aner Ottolenghi, Tamar Levi, Leonid Olender, Zachor Adler-Agmon, Angel Porgador, Roi Gazit
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Cancer immunotherapies are highly potent and are gaining wide clinical usage. However, severe side effects require focusing effector immune cell activities on the tumor microenvironment (TME). We recently developed a chimeric antigen recepto
Externí odkaz:
https://doaj.org/article/a8c3491aaadb47f198961624d9339fd6
Autor:
Gurucharan Sudarshan, Simy Weil, Noa Rotem-Dai, Rivka Manor, Yariv Greenshpan, Oron Goldstein, Omri Sharabi, Eliahu D. Aflalo, Rivka Ofir, Benyamin Rosental, Roi Gazit, Amir Sagi
Publikováno v:
Frontiers in Marine Science, Vol 9 (2023)
Crustacean cell line immortalization has gained a great deal of attention in recent decades for both scientific and applied reasons. Our goal in this study was to advance the state of art towards establishing an immortalized cell line by improving th
Externí odkaz:
https://doaj.org/article/6369dcb9e9d44885a84dee407bee36e9
Autor:
Aner Ottolenghi, Priyanka Bolel, Rhitajit Sarkar, Yariv Greenshpan, Muhammed Iraqi, Susmita Ghosh, Baisali Bhattacharya, Zoe V. Taylor, Kiran Kundu, Olga Radinsky, Roi Gazit, David Stepensky, Ron N. Apte, Elena Voronov, Angel Porgador
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract IL-2 is the master-regulator cytokine for T cell dependent responses and is crucial for proliferation and survival of T cells. However, IL-2-based treatments remained marginal, in part due to short half-life. Thus, we aimed to extend IL-2 ha
Externí odkaz:
https://doaj.org/article/ad6cc7eb08a2453fb99bf074bf0f2812
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-13 (2021)
Abstract Animal models are necessary to study cancer and develop treatments. After decades of intensive research, effective treatments are available for only a few types of leukemia, while others are currently incurable. Our goal was to generate nove
Externí odkaz:
https://doaj.org/article/d1ec3c7cfcdb4ce7a5dd65f1ed856c47
Autor:
Yariv Greenshpan, Omri Sharabi, Aner Ottolenghi, Avishag Cahana, Kiran Kundu, Ksenia M. Yegodayev, Moshe Elkabets, Roi Gazit, Angel Porgador
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Greenshpan et al. explore the use of synthetic promoters based on IFNgamma, TNF alpha and hypoxia responsive elements to control gene expression. The authors describe this technology in the context of chimeric antigen expression (CAR) and propose tha
Externí odkaz:
https://doaj.org/article/e0c47efecb0d4ae69091de751e705b6f
Autor:
Noa Rotem-Dai, Simy Weil, Yariv Greenshpan, Shai Abehsera, Rivka Manor, Rivka Ofir, Roi Gazit, Benyamin Rosental, Eliahu D. Aflalo, Amir Sagi
Publikováno v:
Frontiers in Marine Science, Vol 8 (2021)
Novel monosex biotechnologies in crustacean aquaculture involve the induction of sex reversal through manipulations of the androgenic gland (AG), and its most prominent factor, the insulin-like androgenic gland (IAG) hormone, during early development
Externí odkaz:
https://doaj.org/article/77fd077d74e44f4e935d3dd4a65fd4f0
Autor:
Michael Timaner, Ziv Raviv, Shai Shen-Orr, Yuval Shaked, Tongwu Zhang, Ksenia Magidey-Klein, Tim J Cooper, Ksenya Kveler, Rachelly Normand, Brian P. James, Roi Gazit, Ze'ev A. Ronai
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Metastasis is the major cause of death in patients with cancer. Myeloid skewing of hematopoietic cells is a prominent promoter of metastasis. However, the reservoir of these cells in the bone marrow (BM) compartment and their differentiati
Externí odkaz:
https://doaj.org/article/b1eb6c9ab4594ba7bc4b1dc99865ddec