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Akademický článek

Characterising the efficacy and bioavailability of bioactive peptides identified for attenuating muscle atrophy within a Vicia faba-derived functional ingredient

Autor: Alberto R. Corrochano, Roi Cal, Kathy Kennedy, Audrey Wall, Niall Murphy, Sanja Trajkovic, Sean O’Callaghan, Alessandro Adelfio, Nora Khaldi

Publikováno v: Current Research in Food Science, Vol 4, Iss , Pp 224-232 (2021)

Characterising key components within functional ingredients as well as assessing efficacy and bioavailability is an important step in validating nutritional interventions. Machine learning can assess large and complex data sets, such as proteomic dat

Externí odkaz: https://doaj.org/article/5c8f719cf1ef40cd94810bd00f1d9470

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Akademický článek

Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes.

Autor: Montserrat Barriga, Roi Cal, Nuria Cabello, Anna Llach, Alexander Vallmitjana, Raúl Benítez, Lina Badimon, Juan Cinca, Vicenta Llorente-Cortés, Leif Hove-Madsen

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58128 (2013)

The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the hypothesis that Low Density Lip

Externí odkaz: https://doaj.org/article/9f07f14d9de54c718bd766ca1b31e3f7

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Characterising the efficacy and bioavailability of bioactive peptides identified for attenuating muscle atrophy within a Vicia faba-derived functional ingredient

Autor: Alessandro Adelfio, Nora Khaldi, Roi Cal, Niall Murphy, Sanja Trajkovic, Audrey Wall, Sean O’Callaghan, Kathy Kennedy, Alberto R. Corrochano

Publikováno v: Current Research in Food Science, Vol 4, Iss, Pp 224-232 (2021)
Current Research in Food Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d10ee4ee6954d156f8827ebb46a791
https://doi.org/10.1016/j.crfs.2021.03.008

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Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy

Autor: Nora Khaldi, Alish Kerr, Sweeny Chauhan, Alessandro Adelfio, Ian Holyer, Brendan Molloy, Roi Cal, Sanja Trajkovic, Audrey Wall, Heidi Davis

Publikováno v: Nutrients, Vol 12, Iss 2274, p 2274 (2020)
Nutrients
Volume 12
Issue 8

Skeletal muscle is the metabolic powerhouse of the body, however, dysregulation of the mechanisms involved in skeletal muscle mass maintenance can have devastating effects leading to many metabolic and physiological diseases. The lack of effective so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cf4e9c0f6b58926d4f7ab4c1030556
https://www.mdpi.com/2072-6643/12/8/2274

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The anti-ageing effects of a natural peptide discovered by artificial intelligence

Autor: Nora Khaldi, Thérèse A. Holton, Cyril Lopez, Kathy Kennedy, Rory Casey, Brendan Molloy, Audrey Wall, Alessandro Adelfio, Roi Cal

Publikováno v: International journal of cosmetic scienceReferences. 42(4)

As skin ages, impaired extracellular matrix (ECM) protein synthesis and increased action of degradative enzymes manifest as atrophy, wrinkling and laxity. There is mounting evidence for the functional role of exogenous peptides across many areas, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131a45c8bb3ae6ad1830b555b9f1ed4b
https://pubmed.ncbi.nlm.nih.gov/32453870

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Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes

Autor: José M. Castellano, Vicenta Llorente-Cortés, Leif Hove-Madsen, Montse Barriga, Jordi Farré, Roi Cal, Elena Revuelta-López, Gemma Vilahur, Rosa Aledo, Lina Badimon, Laura Nasarre

Publikováno v: Cardiovascular Research. 94:469-479

Aims The myocardium accumulates intracellular lipids under ischaemic conditions, and myocardial fat deposition is closely associated with cardiac dysfunction. Our aims were to analyse the effect of hypoxia on low-density lipoprotein receptor-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef626e07be64eba0041debaa81add579
https://doi.org/10.1093/cvr/cvs136

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Cholesterol-lowering strategies reduce vascular LRP1 overexpression induced by hypercholesterolaemia

Autor: Roi Cal, Laura Casaní, Sandra Camino-López, Vicenta Llorente-Cortés, Albert Llenas, Lina Badimon, Oriol Juan-Babot, Judith Sendra

Publikováno v: European Journal of Clinical Investigation. 41:1087-1097

Eur J Clin Invest 2011; 41 (10): 1087–1097 Abstract Background Low density lipoprotein receptor-related protein (LRP1) plays a key role on vascular functionality and is upregulated by hypercholesterolemia and hypertension. To investigate the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f8af2c5f0f099815dc7b7be7728ecab
https://doi.org/10.1111/j.1365-2362.2011.02513.x

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Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes

Autor: David de Gonzalo-Calvo, Carolina Gálvez-Montón, Santiago Roura, Leif Hove-Madsen, Roi Cal, Adela Herraiz-Martínez, Elena Revuelta-López, Lina Badimon, Laura Nasarre, Vicenta Llorente-Cortés, Antoni Bayes-Genis

Publikováno v: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

The maintenance of sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activity is crucial for cardiac function and SERCA2 is dramatically reduced in the heart exposed to hypoxic/ischemic conditions. Previous work from our group showed that hypoxia upregulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573af59d969ceae4c360b34c407cb638
https://pubmed.ncbi.nlm.nih.gov/25968337

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Hypoxia worsens the impact of intracellular triglyceride accumulation promoted by electronegative low-density lipoprotein in cardiomyocytes by impairing perilipin 5 upregulation

Autor: Lina Badimon, Maria Martínez-Bujidos, Vicenta Llorente-Cortés, Jordi Ordóñez-Llanos, Josep Julve, Roi Cal, Montserrat Pérez-Cuellar, Elena Revuelta-López, Anna Rull, José Luis Sánchez-Quesada

Publikováno v: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Plasma lipoproteins are a source of lipids for the heart, and the proportion of electronegative low density lipoprotein [LDL(-)] is elevated in cardiometabolic diseases. Perilipin 5 (Plin5) is a crucial protein for lipid droplet management in the hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d70cd06fd3ee756e740920c21654e4
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8440

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Low Density Lipoproteins Promote Unstable Calcium Handling Accompanied by Reduced SERCA2 and Connexin-40 Expression in Cardiomyocytes

Autor: Vicenta Llorente-Cortés, Juan Cinca, Leif Hove-Madsen, Alexander Vallmitjana, Montserrat Barriga, Lina Badimon, Anna Llach, Nuria Cabello, Raul Benitez, Roi Cal

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58128 (2013)
Recercat. Dipósit de la Recerca de Catalunya
instname
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a56cf10df68a0a9404ea43f15bfd16
http://hdl.handle.net/10261/148361

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