Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Rohith Srivas"'
Autor:
Shining Ma, Michelle So, Aazam Ghelani, Rohith Srivas, Anupama Sahoo, Robyn Hall, Wenjun Liu, Hao Wu, Sherman Yu, Shiping Lu, Elly Song, Taryn Cariaga, Marcus Soto, Hong Zhou, Chi-Ming Li, Ashutosh Chaudhry, Xin Luo, Sue J. Sohn
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interleukin-2 (IL-2), along with T-cell receptor (TCR) signaling, are required to control regulatory T cell (Treg) homeostasis and function in vivo. Due to the heightened sensitivity to IL-2, Tregs retain the ability to respond to low-dose or attenua
Externí odkaz:
https://doaj.org/article/4b2f7fa5bd9b408db48f01f99aa68ebe
Autor:
Armando Reyes-Palomares, Mingxia Gu, Fabian Grubert, Ivan Berest, Silin Sa, Maya Kasowski, Christian Arnold, Mao Shuai, Rohith Srivas, Simon Miao, Dan Li, Michael P. Snyder, Marlene Rabinovitch, Judith B. Zaugg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pulmonary arterial hypertension (PAH) is a heterogeneous disease, causing severe breathing problems and cardiac morbidity. Here, the authors study chromatin marks in pulmonary arterial endothelial cells from PAH patients and controls and find changes
Externí odkaz:
https://doaj.org/article/af8f51e6fdcf4006aee980f4873bd8eb
Autor:
Rohith Srivas, Thomas Costelloe, Anne-Ruxandra Carvunis, Sovan Sarkar, Erik Malta, Su Ming Sun, Marijke Pool, Katherine Licon, Tibor van Welsem, Fred van Leeuwen, Peter J. McHugh, Haico van Attikum, Trey Ideker
Publikováno v:
Cell Reports, Vol 5, Iss 6, Pp 1714-1724 (2013)
Efficient repair of UV-induced DNA damage requires the precise coordination of nucleotide excision repair (NER) with numerous other biological processes. To map this crosstalk, we generated a differential genetic interaction map centered on quantitat
Externí odkaz:
https://doaj.org/article/49b48a24b019447baf1e06106fc31587
Autor:
Gregory Hannum, Rohith Srivas, Aude Guénolé, Haico van Attikum, Nevan J Krogan, Richard M Karp, Trey Ideker
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000782 (2009)
This work demonstrates how gene association studies can be analyzed to map a global landscape of genetic interactions among protein complexes and pathways. Despite the immense potential of gene association studies, they have been challenging to analy
Externí odkaz:
https://doaj.org/article/b0667f42ec8144bdb326d0943e7e7c05
Autor:
Akshay Sanghi, Stephen Dalton, Maya Kasowski, Michael Kulik, Fabian Grubert, Damek V. Spacek, Mariana Ruiz-Velasco, Qing Liu, Anshul Kundaje, Marlene Rabinovitch, Benjamin Geller, Anil Narasimha, Peyton Greenside, Judith B. Zaugg, Nasa Sinnott-Armstrong, Michael Snyder, Silin Sa, Rohith Srivas
Publikováno v:
Nature
Physical interactions between distal regulatory elements have a key role in regulating gene expression, but the extent to which these interactions vary between cell types and contribute to cell-type-specific gene expression remains unclear. Here, to
Autor:
Nicole J. Lambert, Ken Nesmith, Haluk Tezcan, Becky Wong, Andrew M. Davis, Ayse Tezcan, Young Kwang Chae, Neil Peterman, Michael S. Oh, Wade T. Iams, Timothy R. Wilson, Abhik Shah, Robert W. Lentz, Jason Close, Rohith Srivas, Haleigh Wood, David Chan, Alex Robertson, Peter George
Publikováno v:
Mol Cancer Ther
Treatment response assessment for patients with advanced solid tumors is complex and existing methods require greater precision. Current guidelines rely on imaging, which has known limitations, including the time required to show a deterministic chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bafbcdaa220a134c176d6f50262322
https://europepmc.org/articles/PMC8142024/
https://europepmc.org/articles/PMC8142024/
Autor:
Ivan Berest, Silin Sa, Christian Arnold, Michael Snyder, Armando Reyes-Palomares, Maya Kasowski, Marlene Rabinovitch, Fabian Grubert, Mao Shuai, Rohith Srivas, Mingxia Gu, Simon Miao, Dan Li, Judith B. Zaugg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Environmental and epigenetic factors often play an important role in polygenic disorders. However, how such factors affect disease-specific tissues at the molecular level remains to be understood. Here, we address this in pulmonary arterial hypertens
Autor:
Peterman, Neil, Robertson, Alex, Abhik Shah, Rohith Srivas, Lambert, Nicole, Wilson, Tim, George, Peter, Wong, Becky, Ayse Tezcan, Yalamanchili, Ram, Spinosa, John, Tezcan, Haluk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c6d43de778807bdb98567a502f81a8
Autor:
Haico van Attikum, Kirsten van Harten, Iris J. E. Stulemeijer, Trey Ideker, Rohith Srivas, Fred van Leeuwen, Su Ming Sun, Farid El Oualid, Hanneke Vlaming, Tineke L. Lenstra, Dominique Morais, Tibor van Welsem, Huib Ovaa, Frank C. P. Holstege, Tessy Korthout, Reggy Ekkebus, Deepani W. Poramba-Liyanage, Thom M Molenaar
Publikováno v:
Nucleic Acids Research
Nucleic acids research, 46(21), 11251-11261. Oxford University Press
Nucleic Acids Research, 46(21), 11251-11261
Nucleic acids research, 46(21), 11251-11261. Oxford University Press
Nucleic Acids Research, 46(21), 11251-11261
The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca968c97e6ee05a0158c1e40575b5132
https://hdl.handle.net/1887/86410
https://hdl.handle.net/1887/86410
Autor:
Jason F. Kreisberg, Michael Kramer, Trey Ideker, Michael Ku Yu, Rohith Srivas, Nevan J. Krogan, Janusz Dutkowski, Katherine Licon, Cherie T. Ng, Roded Sharan
Publikováno v:
Cell systems
Summary Accurately translating genotype to phenotype requires accounting for the functional impact of genetic variation at many biological scales. Here we present a strategy for genotype-phenotype reasoning based on existing knowledge of cellular sub