Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Rohit K Jangra"'
Autor:
Paula Ortega-Gonzalez, Gwen Taylor, Rohit K Jangra, Raquel Tenorio, Isabel Fernandez de Castro, Bernardo A Mainou, Robert C Orchard, Craig B Wilen, Pamela H Brigleb, Jorna Sojati, Kartik Chandran, Martin Sachse, Cristina Risco, Terence S Dermody
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010322 (2022)
Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficki
Externí odkaz:
https://doaj.org/article/9a120a5913574c848a92d601c03ff421
Autor:
Gorka Lasso, Saad Khan, Stephanie A Allen, Margarette Mariano, Catalina Florez, Erika P Orner, Jose A Quiroz, Gregory Quevedo, Aldo Massimi, Aditi Hegde, Ariel S Wirchnianski, Robert H Bortz, Ryan J Malonis, George I Georgiev, Karen Tong, Natalia G Herrera, Nicholas C Morano, Scott J Garforth, Avinash Malaviya, Ahmed Khokhar, Ethan Laudermilch, M Eugenia Dieterle, J Maximilian Fels, Denise Haslwanter, Rohit K Jangra, Jason Barnhill, Steven C Almo, Kartik Chandran, Jonathan R Lai, Libusha Kelly, Johanna P Daily, Olivia Vergnolle
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009778 (2022)
The clinical outcome of SARS-CoV-2 infection varies widely between individuals. Machine learning models can support decision making in healthcare by assessing fatality risk in patients that do not yet show severe signs of COVID-19. Most predictive mo
Externí odkaz:
https://doaj.org/article/6e20ef620826496397e91cdbc58ba169
Autor:
Maria Eugenia Dieterle, Carles Solà-Riera, Chunyan Ye, Samuel M Goodfellow, Eva Mittler, Ezgi Kasikci, Steven B Bradfute, Jonas Klingström, Rohit K Jangra, Kartik Chandran
Publikováno v:
eLife, Vol 10 (2021)
Hantaviruses are RNA viruses with known epidemic threat and potential for emergence. Several rodent-borne hantaviruses cause zoonoses accompanied by severe illness and death. However, assessments of zoonotic risk and the development of countermeasure
Externí odkaz:
https://doaj.org/article/a684584571bc40729ea1257e848286e2
Autor:
Priscilla F Kerkman, Andy Dernstedt, Lalitha Tadala, Eva Mittler, Mirjam Dannborg, Christopher Sundling, Kimia T Maleki, Johanna Tauriainen, Anne Tuiskunen‐Bäck, Julia Wigren Byström, Pauline Ocaya, Therese Thunberg, Rohit K Jangra, Gleyder Román‐Sosa, Pablo Guardado‐Calvo, Felix A Rey, Jonas Klingström, Kartik Chandran, Andrea Puhar, Clas Ahlm, Mattias NE Forsell
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)
Abstract Objective Human hantavirus infections can cause haemorrhagic fever with renal syndrome (HFRS). The pathogenic mechanisms are not fully understood, nor if they affect the humoral immune system. The objective of this study was to investigate h
Externí odkaz:
https://doaj.org/article/060cd2105d64425aa611f3c3c98fe865
Autor:
Jose A Quiroz, Ryan J Malonis, Larissa B Thackray, Courtney A Cohen, Jesper Pallesen, Rohit K Jangra, Rebecca S Brown, Daniel Hofmann, Frederick W Holtsberg, Sergey Shulenin, Elisabeth K Nyakatura, Lorellin A Durnell, Vinayak Rayannavar, Johanna P Daily, Andrew B Ward, M Javad Aman, John M Dye, Kartik Chandran, Michael S Diamond, Margaret Kielian, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008061 (2019)
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHI
Externí odkaz:
https://doaj.org/article/a598088c3c3f4bc283f5f862aa24c25e
Autor:
Bryce M Warner, Derek R Stein, Rohit K Jangra, Megan M Slough, Patrycja Sroga, Angela Sloan, Kathy L Frost, Stephanie Booth, Kartik Chandran, David Safronetz
Publikováno v:
Viruses, Vol 11, Iss 7, p 645 (2019)
Andes virus (ANDV) and Sin Nombre virus (SNV) are the main causative agents responsible for hantavirus cardiopulmonary syndrome (HCPS) in the Americas. HCPS is a severe respiratory disease with a high fatality rate for which there are no approved the
Externí odkaz:
https://doaj.org/article/9ce9ee8a9bd0440bb083861ddee670ad
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/b521349c96254a37b1369adf4a6839af
Autor:
Keith E Maier, Rohit K Jangra, Kevin R Shieh, David K Cureton, Hui Xiao, Erik L Snapp, Sean P Whelan, Kartik Chandran, Matthew Levy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Pathogenic New World hemorrhagic fever mammarenaviruses (NWM) utilize Glycoprotein 1 (GP1) to target the apical domain of the human transferrin receptor (hTfR) for facilitating cell entry. However, the conservation between their GP1s is low. Consider
Externí odkaz:
https://doaj.org/article/a5bd80fd6e7c49ac9519261f96d0379b
Autor:
Melinda Ng, Esther Ndungo, Maria E Kaczmarek, Andrew S Herbert, Tabea Binger, Ana I Kuehne, Rohit K Jangra, John A Hawkins, Robert J Gifford, Rohan Biswas, Ann Demogines, Rebekah M James, Meng Yu, Thijn R Brummelkamp, Christian Drosten, Lin-Fa Wang, Jens H Kuhn, Marcel A Müller, John M Dye, Sara L Sawyer, Kartik Chandran
Publikováno v:
eLife, Vol 4 (2015)
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon he
Externí odkaz:
https://doaj.org/article/a4ca56856f3e47a9ba72fff1209120bf
Autor:
Ching-Lin Hsieh, Sarah R. Leist, Emily Happy Miller, Ling Zhou, John M. Powers, Alexandra L. Tse, Albert Wang, Ande West, Mark R. Zweigart, Jonathan C. Schisler, Rohit K. Jangra, Kartik Chandran, Ralph S. Baric, Jason S. McLellan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that offers a greater breadth of protection against current and future VOCs would
Externí odkaz:
https://doaj.org/article/6941a5fbfd994875abc77900a05c8737