Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rohit B. Sharma"'
Autor:
Rachel E. Stamateris, Huguet V. Landa-Galvan, Rohit B. Sharma, Christine Darko, David Redmond, Sushil G. Rane, Laura C. Alonso
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Expanding β cell mass is a critical goal in the fight against diabetes. CDK4, an extensively characterized cell cycle activator, is required to establish and maintain β cell number. β cell failure in the IRS2-deletion mouse type 2 diabetes model i
Externí odkaz:
https://doaj.org/article/432b8a2379a0464cb5ac53497221f766
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell
Externí odkaz:
https://doaj.org/article/34fcff15f65143fa8ca0bab84b4cd93e
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Aging is associated with loss of proliferation of the insulin-secreting β-cell, a possible contributing factor to the increased prevalence of type 2 diabetes in the elderly. Our group previously discovered that moderate endoplasmic reticulum (ER) st
Externí odkaz:
https://doaj.org/article/728bcb8b23a14288b1c2f25dfae7ce74
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp S69-S80 (2019)
Background: A growing body of literature suggests the cell–intrinsic activity of Atf6α during ER stress responses has implications for tissue cell number during growth and development, as well as in adult biology and tumorigenesis [1]. This concep
Externí odkaz:
https://doaj.org/article/418fa9a4e7f64139a5921d7c552d3c30
Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting beta cell differentiation
Autor:
Rachel E. Stamateris, Rohit B. Sharma, Huguet Landa-Galván, Christine Darko, David Redmond, Sushil G. Rane, Laura C. Alonso
Expanding beta cell mass is a critical goal in the fight against diabetes. CDK4, an extensively characterized cell cycle activator, is required to establish and maintain beta cell number. Beta cell failure in the IRS2-deletion mouse type 2 diabetes m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16dfd6408170c7d4344dc3d0b2f0fc8
https://doi.org/10.1101/2022.10.19.512511
https://doi.org/10.1101/2022.10.19.512511
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A.M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Insulin receptor (Insr) protein can be found at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance remain enigmatic. Ins1cre allele was used to delete Insr specifically in β-cells of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c0f17c46700aff483ff285f6a718695
https://doi.org/10.1101/2020.10.15.338160
https://doi.org/10.1101/2020.10.15.338160