Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Rohit A. Sinha"'
Autor:
Rohit A. Sinha
Publikováno v:
Endocrinology and Metabolism, Vol 39, Iss 5, Pp 686-692 (2024)
The influence of thyroid hormone (TH) on liver metabolism has attracted the attention of pharmacologists seeking new treatments for metabolic dysfunction-associated steatotic liver disease (MASLD), an increasingly common metabolic disorder. In this c
Externí odkaz:
https://doaj.org/article/189733149b93498790ed8258536f9776
Autor:
Rohit A. Sinha
Publikováno v:
Liver Research, Vol 8, Iss 1, Pp 34-45 (2024)
The onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic steatohepatitis (NASH) represents a tipping point leading to liver injury and subsequent hepatic complications in the natural progression of what is now termed meta
Externí odkaz:
https://doaj.org/article/efc3666b20d54f10981c267934d17c50
Autor:
Archana Tewari, Sangam Rajak, Sana Raza, Pratima Gupta, Bandana Chakravarti, Jyotika Srivastava, Chandra P. Chaturvedi, Rohit A. Sinha
Publikováno v:
Cells, Vol 12, Iss 14, p 1845 (2023)
Non-alcoholic steatohepatitis (NASH) is a clinically serious stage of non-alcoholic fatty liver disease (NAFLD). Histologically characterized by hepatocyte ballooning, immune cell infiltration, and fibrosis, NASH, at a molecular level, involves lipid
Externí odkaz:
https://doaj.org/article/b975eb2f9c424f2fa79a8bba6bba6499
Publikováno v:
Liver Research, Vol 5, Iss 2, Pp 62-71 (2021)
The incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly across the globe. NAFLD pathogenesis is largely driven by an imbalance in hepatic energy metabolism, and at present, there is no approved drug for its treatment. The liver p
Externí odkaz:
https://doaj.org/article/a1d0de7cb6e44cc79d8055e94305efc4
Autor:
Sangam Rajak, Sherwin Xie, Archana Tewari, Sana Raza, Yajun Wu, Boon-Huat Bay, Paul M. Yen, Rohit A. Sinha
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101286- (2021)
Objective: Crinophagy is a secretory granule-specific autophagic process that regulates hormone content and secretion in endocrine cells. However, despite being one of the earliest described autophagic processes, its mechanism of action and regulatio
Externí odkaz:
https://doaj.org/article/9d5b34b8cf7b486dbe260df9e11bf0cd
Autor:
Sangam Rajak, Liliana F. Iannucci, Jin Zhou, B. Anjum, Nelson George, Brijesh K. Singh, Sujoy Ghosh, Paul M. Yen, Rohit A. Sinha
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The hepatic mevalonate (MVA) pathway, responsible for cholesterol biosynthesis, is a therapeutically important metabolic pathway in clinical medicine. Using an unbiased transcriptomics approach, we uncover a novel role of Unc-51 like autophagy activa
Externí odkaz:
https://doaj.org/article/78ab8411a3ac4d1e97a6b88b8b186848
Autor:
Liliana F. Iannucci, Federica Cioffi, Rosalba Senese, Fernando Goglia, Antonia Lanni, Paul M. Yen, Rohit A. Sinha
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Nonalcoholic fatty liver disease (NAFLD) is a major health problem worldwide, and is often associated with lipotoxic injury, defective mitochondrial function, and insulin resistance. Thyroid hormones (THs) are important regulators of hepatic
Externí odkaz:
https://doaj.org/article/a4890c10cb2c40409ff2e638a86214b1
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 2, Pp 206-237 (2020)
Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, may culminate into cirrhosis and hepatocellular cancer (HCC
Externí odkaz:
https://doaj.org/article/89801d8776684a18a0fad1c415aeb405
Autor:
Madhulika Tripathi, Brijesh Kumar Singh, Jin Zhou, Keziah Tikno, Anissa Widjaja, Reddemma Sandireddy, Kabilesh Arul, Siti Aishah Binte Abdul Ghani, George Goh Boon Bee, Kiraely Adam Wong, Ho Jia Pei, Shamini Guna Shekeran, Rohit Anthony Sinha, Manvendra K. Singh, Stuart Alexander Cook, Ayako Suzuki, Teegan Reina Lim, Chang-Chuen Cheah, Jue Wang, Rui-Ping Xiao, Xiuqing Zhang, Pierce Kah Hoe Chow, Paul Michael Yen
Publikováno v:
Journal of Hepatology. 77:1246-1255
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdeeb15d918f2f01f10879161aae177
https://doi.org/10.1016/j.jhep.2022.06.033
https://doi.org/10.1016/j.jhep.2022.06.033
Autor:
Madhulika Tripathi, Brijesh Kumar Singh, Elisa A. Liehn, Sheau Yng Lim, Keziah Tikno, David Castano-Mayan, Chutima Rattanasopa, Pakhwan Nilcham, Siti Aishah Binte Abdul Ghani, Zihao Wu, Syaza Hazwany Azhar, Jin Zhou, Sauri Hernández-Resèndiz, Gustavo E. Crespo-Avilan, Rohit Anthony Sinha, Benjamin Livingston Farah, Kyaw Thu Moe, Deidre Anne De Silva, Veronique Angeli, Manvendra K. Singh, Roshni R. Singaraja, Derek J. Hausenloy, Paul Michael Yen
Publikováno v:
Autophagy
Caffeine is among the most highly consumed substances worldwide, and it has been associated with decreased cardiovascular risk. Although caffeine has been shown to inhibit the proliferation of vascular smooth muscle cells (VSMCs), the mechanism under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241cc01bddb9a4722dd9c93310eaa9b1
https://pubmed.ncbi.nlm.nih.gov/35012409
https://pubmed.ncbi.nlm.nih.gov/35012409