Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Rohinton S Tarapore"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 5, Pp 472-480 (2013)
Esophageal cancer is the eighth most common cancer in the world and has an extremely dismal prognosis, with a 5-year survival of less than 20%. Current treatment options are limited, and thus identifying new molecular targets and pathways is critical
Externí odkaz:
https://doaj.org/article/d0738edffd684f3c98c9ced03bfd32ba
Autor:
Hifzur Rahman Siddique, Aijaz Parray, Rohinton S Tarapore, Lei Wang, Hasan Mukhtar, R Jeffery Karnes, Yibin Deng, Badrinath R Konety, Mohammad Saleem
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e60664 (2013)
For advanced prostate cancer (CaP), the progression of tumors to the state of chemoresistance and paucity of knowledge about the mechanism of chemoresistance are major stumbling blocks in the management of this disease. Here, we provide compelling ev
Externí odkaz:
https://doaj.org/article/15a6458188a9404e9c49a2b4b0ce30e7
Autor:
Varun Vijay Prabhu, Sara Morrow, Abed Rahman Kawakibi, Lanlan Zhou, Marie Ralff, Jocelyn Ray, Aakash Jhaveri, Isacco Ferrarini, Young Lee, Cassandra Parker, Yiqun Zhang, Robyn Borsuk, Wen-I Chang, Joshua N. Honeyman, Fabio Tavora, Benedito Carneiro, Alexander Raufi, Kelsey Huntington, Lindsey Carlsen, Anna Louie, Howard Safran, Attila A. Seyhan, Rohinton S. Tarapore, Lee Schalop, Martin Stogniew, Joshua E. Allen, Wolfgang Oster, Wafik S. El-Deiry
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agon
Externí odkaz:
https://doaj.org/article/ab2136215d2b48418947dffdd2998a3e
Autor:
Mark N. Stein, Jyoti Malhotra, Rohinton S. Tarapore, Usha Malhotra, Ann W. Silk, Nancy Chan, Lorna Rodriguez, Joseph Aisner, Robert D. Aiken, Tina Mayer, Bruce G. Haffty, Jenna H. Newman, Salvatore M. Aspromonte, Praveen K. Bommareddy, Ricardo Estupinian, Charles B. Chesson, Evita T. Sadimin, Shengguo Li, Daniel J. Medina, Tracie Saunders, Melissa Frankel, Aparna Kareddula, Sherrie Damare, Elayne Wesolowsky, Christian Gabel, Wafik S. El-Deiry, Varun V. Prabhu, Joshua E. Allen, Martin Stogniew, Wolfgang Oster, Joseph R. Bertino, Steven K. Libutti, Janice M. Mehnert, Andrew Zloza
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Background ONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy and immunomodulatory properties in preclinical models. The first-in-human tri
Externí odkaz:
https://doaj.org/article/cc2e3e6b70b34104941a2588a1bfa557
Autor:
Joshua E. Allen, Wolfgang Oster, Patrick Y. Wen, Tracy T. Batchelor, Isabel Arrillaga-Romany, Robert Wechsler-Reya, Jessica Rusert, Mark R. Gilbert, Deric M. Park, Jinkyu Jung, Neil Charter, Sean Deacon, Rohinton S. Tarapore, Jessica Durrant, Alexander VanEngelenburg, Faye Doherty, Olivier Elemento, Wafik S. El-Deiry, Sophie Oster, C. Leah B. Kline, Coryandar Gilvary, Neel S. Madhukar, Varun V. Prabhu
Figure S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e308d507bf1d92c73420b66051a502d5
https://doi.org/10.1158/1078-0432.22472331
https://doi.org/10.1158/1078-0432.22472331
Autor:
Joshua E. Allen, Wolfgang Oster, Patrick Y. Wen, Tracy T. Batchelor, Isabel Arrillaga-Romany, Robert Wechsler-Reya, Jessica Rusert, Mark R. Gilbert, Deric M. Park, Jinkyu Jung, Neil Charter, Sean Deacon, Rohinton S. Tarapore, Jessica Durrant, Alexander VanEngelenburg, Faye Doherty, Olivier Elemento, Wafik S. El-Deiry, Sophie Oster, C. Leah B. Kline, Coryandar Gilvary, Neel S. Madhukar, Varun V. Prabhu
Purpose:Dopamine receptor D2 (DRD2) is a G protein–coupled receptor antagonized by ONC201, an anticancer small molecule in clinical trials for high-grade gliomas and other malignancies. DRD5 is a dopamine receptor family member that opposes DRD2 si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5247f7654a50fe6322025926a51c4f46
https://doi.org/10.1158/1078-0432.c.6528195
https://doi.org/10.1158/1078-0432.c.6528195
Autor:
Joshua E. Allen, Wolfgang Oster, Patrick Y. Wen, Tracy T. Batchelor, Isabel Arrillaga-Romany, Robert Wechsler-Reya, Jessica Rusert, Mark R. Gilbert, Deric M. Park, Jinkyu Jung, Neil Charter, Sean Deacon, Rohinton S. Tarapore, Jessica Durrant, Alexander VanEngelenburg, Faye Doherty, Olivier Elemento, Wafik S. El-Deiry, Sophie Oster, C. Leah B. Kline, Coryandar Gilvary, Neel S. Madhukar, Varun V. Prabhu
Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86181d49990cf8948bf53f9c5827dffc
https://doi.org/10.1158/1078-0432.22472319
https://doi.org/10.1158/1078-0432.22472319
Autor:
Joshua E. Allen, Wolfgang Oster, Patrick Y. Wen, Tracy T. Batchelor, Isabel Arrillaga-Romany, Robert Wechsler-Reya, Jessica Rusert, Mark R. Gilbert, Deric M. Park, Jinkyu Jung, Neil Charter, Sean Deacon, Rohinton S. Tarapore, Jessica Durrant, Alexander VanEngelenburg, Faye Doherty, Olivier Elemento, Wafik S. El-Deiry, Sophie Oster, C. Leah B. Kline, Coryandar Gilvary, Neel S. Madhukar, Varun V. Prabhu
Supplementary legends for Figures S1-S5 and Tables S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1862ccddb1e46f633458f1fcb1dfb754
https://doi.org/10.1158/1078-0432.22472322.v1
https://doi.org/10.1158/1078-0432.22472322.v1
Autor:
Isabel Arrillaga-Romany, Andrew Lassman, Susan L. McGovern, Sabine Mueller, Louis B. Nabors, Martin van den Bent, Michael Vogelbaum, Joshua E. Allen, Allen S. Melemed, Rohinton S. Tarapore, Dewen Yang, Patrick Wen, Timothy Cloughsey
Publikováno v:
Cancer Research. 83:CT060-CT060
Background: H3 K27M-mutant diffuse midline glioma is a universally fatal malignancy primarily affecting children and young adults. While radiotherapy (RT) provides transient benefit, no effective systemic therapy is currently available and current st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::037d5b4775675ac5cc9ae54279a7ef81
https://doi.org/10.1158/1538-7445.am2023-ct060
https://doi.org/10.1158/1538-7445.am2023-ct060
Autor:
Evan Cantor, Kyle Wierzbicki, Rohinton S Tarapore, Karthik Ravi, Chase Thomas, Rodrigo Cartaxo, Viveka Nand Yadav, Ramya Ravindran, Amy K Bruzek, Jack Wadden, Vishal John, Clarissa May Babila, Jessica R Cummings, Abed Rahman Kawakibi, Sunjong Ji, Johanna Ramos, Alyssa Paul, Dustin Walling, Marcia Leonard, Patricia Robertson, Andrea Franson, Rajen Mody, Hugh J L Garton, Sriram Venneti, Yazmin Odia, Cassie Kline, Nicholas A Vitanza, Soumen Khatua, Sabine Mueller, Joshua E Allen, Sharon L Gardner, Carl Koschmann
Publikováno v:
Neuro Oncol
Background Diffuse Midline Glioma (DMG) with the H3K27M mutation is a lethal childhood brain cancer, with patients rarely surviving 2 years from diagnosis. Methods We conducted a multi-site Phase 1 trial of the imipridone ONC201 for children with H3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2730b5db78fa10457b8a27c6518d2a
https://pubmed.ncbi.nlm.nih.gov/35323938
https://pubmed.ncbi.nlm.nih.gov/35323938